CCDC74A — 95 ClinVar variants
All ClinVar germline CCDC74A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →
1 Benign · 11 Likely benign · 83 Uncertain significance
Full CCDC74A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 83
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 72
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC74A c.296-114C>T Uncertain significance Single submitter
- CCDC74A c.296-121G>C Uncertain significance Single submitter
- CCDC74A c.296-12G>A Uncertain significance Single submitter
- CCDC74A c.296-139T>A Uncertain significance Single submitter
- CCDC74A c.296-147G>A Uncertain significance Single submitter
- CCDC74A c.296-151G>A Uncertain significance Single submitter
- CCDC74A c.296-154G>A Uncertain significance Single submitter
- CCDC74A c.296-174C>G Uncertain significance Single submitter
- CCDC74A c.296-177T>C Uncertain significance Single submitter
- CCDC74A c.296-18C>T Uncertain significance Single submitter
- CCDC74A c.296-43C>T Uncertain significance Single submitter
- CCDC74A c.296-7C>T Uncertain significance Single submitter
- CCDC74A p.Ala168Val Uncertain significance Single submitter
- CCDC74A p.Ala190Ser Uncertain significance Single submitter
- CCDC74A p.Ala190Val Uncertain significance Single submitter
- CCDC74A p.Ala279Val Uncertain significance Single submitter
- CCDC74A p.Ala283Thr Uncertain significance Single submitter
- CCDC74A p.Arg201Gln Uncertain significance Single submitter
- CCDC74A p.Arg214Cys Uncertain significance Single submitter
- CCDC74A p.Arg214His Uncertain significance Single submitter
- CCDC74A p.Arg21Gly Uncertain significance Single submitter
- CCDC74A p.Arg24His Uncertain significance Single submitter
- CCDC74A p.Arg278Cys Uncertain significance Single submitter
- CCDC74A p.Arg278Pro Uncertain significance Single submitter
- CCDC74A p.Arg295Gly Uncertain significance Single submitter
- CCDC74A p.Arg305Gln Uncertain significance Single submitter
- CCDC74A p.Arg306Cys Uncertain significance Single submitter
- CCDC74A p.Arg306His Uncertain significance Single submitter
- CCDC74A p.Cys175Arg Uncertain significance Single submitter
- CCDC74A p.Gln107Arg Uncertain significance Single submitter
- CCDC74A p.Gln182His Uncertain significance Single submitter
- CCDC74A p.Gln96Lys Uncertain significance Single submitter
- CCDC74A p.Glu167Gln Uncertain significance Single submitter
- CCDC74A p.Glu210Lys Uncertain significance Single submitter
- CCDC74A p.Glu215Gly Uncertain significance Single submitter
- CCDC74A p.Glu215Lys Uncertain significance Single submitter
- CCDC74A p.Glu277Val Uncertain significance Single submitter
- CCDC74A p.Glu81Lys Uncertain significance Single submitter
- CCDC74A p.Gly123Val Uncertain significance Single submitter
- CCDC74A p.Gly156Ala Uncertain significance Single submitter
- CCDC74A p.Gly189Ala Uncertain significance Single submitter
- CCDC74A p.Gly19Asp Uncertain significance Single submitter
- CCDC74A p.Gly236Glu Uncertain significance Single submitter
- CCDC74A p.Gly30Ala Uncertain significance Single submitter
- CCDC74A p.Gly5Glu Uncertain significance Single submitter
- CCDC74A p.His257Arg Uncertain significance Single submitter
- CCDC74A p.His308Pro Uncertain significance Single submitter
- CCDC74A p.His86Arg Uncertain significance Single submitter
- CCDC74A p.Ile75Met Uncertain significance Single submitter
- CCDC74A p.Leu101Phe Uncertain significance Single submitter
- CCDC74A p.Leu140Pro Uncertain significance Single submitter
- CCDC74A p.Leu216Arg Uncertain significance Single submitter
- CCDC74A p.Leu78Arg Uncertain significance Single submitter
- CCDC74A p.Leu89Ile Uncertain significance Single submitter
- CCDC74A p.Lys163Asn Uncertain significance Single submitter
- CCDC74A p.Lys268Glu Uncertain significance Single submitter
- CCDC74A p.Lys304Thr Uncertain significance Single submitter
- CCDC74A p.Lys83Arg Uncertain significance Single submitter
- CCDC74A p.Met103Ile Uncertain significance Single submitter
- CCDC74A p.Phe59Leu Uncertain significance Single submitter
- CCDC74A p.Pro12Arg Uncertain significance Single submitter
- CCDC74A p.Pro12Ser Uncertain significance Single submitter
- CCDC74A p.Pro193Ala Uncertain significance Single submitter
- CCDC74A p.Pro27Arg Uncertain significance Single submitter
- CCDC74A p.Ser262Pro Uncertain significance Single submitter
- CCDC74A p.Ser267Ala Uncertain significance Single submitter
- CCDC74A p.Ser28Phe Uncertain significance Single submitter
- CCDC74A p.Ser44Arg Uncertain significance Single submitter
- CCDC74A p.Thr10Met Uncertain significance Single submitter
- CCDC74A p.Thr17Ile Uncertain significance Single submitter
- CCDC74A p.Thr256Pro Uncertain significance Single submitter
- CCDC74A p.Val261Phe Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CCDC74A c.296-130G>A Uncertain significance Single submitter
- CCDC74A p.Arg26Cys Uncertain significance Single submitter
- CCDC74A p.Gln63Arg Uncertain significance Single submitter
- CCDC74A p.Gln63His Uncertain significance Single submitter
- CCDC74A p.Gly9Arg Uncertain significance Single submitter
- CCDC74A p.Ile90Arg Uncertain significance Single submitter
- CCDC74A p.Leu284Pro Uncertain significance Single submitter
- CCDC74A p.Lys264Asn Uncertain significance Single submitter
- CCDC74A p.Met91Ile Uncertain significance Single submitter
- CCDC74A p.Pro282Ser Uncertain significance Single submitter
- CCDC74A p.Ser102Phe Uncertain significance Single submitter
All CCDC74A variants
Benign 1
- p.Met103Thr Single submitter
Likely benign 11
- c.296-25G>A Single submitter
- c.296-31G>A Single submitter
- c.296-42G>A Single submitter
- p.Ala301Val Single submitter
- p.Arg184Lys Single submitter
- p.Asn170= Single submitter
- p.His191Pro Single submitter
- p.Lys297= Single submitter
- p.Pro193Leu Single submitter
- p.Pro288Leu Single submitter
- p.Thr256Met Single submitter
Uncertain significance 83
- c.296-114C>T Single submitter ⚠
- c.296-121G>C Single submitter ⚠
- c.296-12G>A Single submitter ⚠
- c.296-130G>A Single submitter ⚠
- c.296-139T>A Single submitter ⚠
- c.296-147G>A Single submitter ⚠
- c.296-151G>A Single submitter ⚠
- c.296-154G>A Single submitter ⚠
- c.296-174C>G Single submitter ⚠
- c.296-177T>C Single submitter ⚠
- c.296-18C>T Single submitter ⚠
- c.296-43C>T Single submitter ⚠
- c.296-7C>T Single submitter ⚠
- p.Ala168Val Single submitter ⚠
- p.Ala190Ser Single submitter ⚠
- p.Ala190Val Single submitter ⚠
- p.Ala279Val Single submitter ⚠
- p.Ala283Thr Single submitter ⚠
- p.Arg201Gln Single submitter ⚠
- p.Arg214Cys Single submitter ⚠
- p.Arg214His Single submitter ⚠
- p.Arg21Gly Single submitter ⚠
- p.Arg24His Single submitter ⚠
- p.Arg26Cys Single submitter ⚠
- p.Arg278Cys Single submitter ⚠
- p.Arg278Pro Single submitter ⚠
- p.Arg295Gly Single submitter ⚠
- p.Arg305Gln Single submitter ⚠
- p.Arg306Cys Single submitter ⚠
- p.Arg306His Single submitter ⚠
- p.Cys175Arg Single submitter ⚠
- p.Gln107Arg Single submitter ⚠
- p.Gln182His Single submitter ⚠
- p.Gln63Arg Single submitter ⚠
- p.Gln63His Single submitter ⚠
- p.Gln96Lys Single submitter ⚠
- p.Glu167Gln Single submitter ⚠
- p.Glu210Lys Single submitter ⚠
- p.Glu215Gly Single submitter ⚠
- p.Glu215Lys Single submitter ⚠
- p.Glu277Val Single submitter ⚠
- p.Glu81Lys Single submitter ⚠
- p.Gly123Val Single submitter ⚠
- p.Gly156Ala Single submitter ⚠
- p.Gly189Ala Single submitter ⚠
- p.Gly19Asp Single submitter ⚠
- p.Gly236Glu Single submitter ⚠
- p.Gly30Ala Single submitter ⚠
- p.Gly5Glu Single submitter ⚠
- p.Gly9Arg Single submitter ⚠
- p.His257Arg Single submitter ⚠
- p.His308Pro Single submitter ⚠
- p.His86Arg Single submitter ⚠
- p.Ile75Met Single submitter ⚠
- p.Ile90Arg Single submitter ⚠
- p.Leu101Phe Single submitter ⚠
- p.Leu140Pro Single submitter ⚠
- p.Leu216Arg Single submitter ⚠
- p.Leu284Pro Single submitter ⚠
- p.Leu78Arg Single submitter ⚠
- p.Leu89Ile Single submitter ⚠
- p.Lys163Asn Single submitter ⚠
- p.Lys264Asn Single submitter ⚠
- p.Lys268Glu Single submitter ⚠
- p.Lys304Thr Single submitter ⚠
- p.Lys83Arg Single submitter ⚠
- p.Met103Ile Single submitter ⚠
- p.Met91Ile Single submitter ⚠
- p.Phe59Leu Single submitter ⚠
- p.Pro12Arg Single submitter ⚠
- p.Pro12Ser Single submitter ⚠
- p.Pro193Ala Single submitter ⚠
- p.Pro27Arg Single submitter ⚠
- p.Pro282Ser Single submitter ⚠
- p.Ser102Phe Single submitter ⚠
- p.Ser262Pro Single submitter ⚠
- p.Ser267Ala Single submitter ⚠
- p.Ser28Phe Single submitter ⚠
- p.Ser44Arg Single submitter ⚠
- p.Thr10Met Single submitter ⚠
- p.Thr17Ile Single submitter ⚠
- p.Thr256Pro Single submitter ⚠
- p.Val261Phe Single submitter ⚠