CCDC74B — 90 ClinVar variants
All ClinVar germline CCDC74B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →
8 Likely benign · 82 Uncertain significance
Full CCDC74B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 83
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 72
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC74B c.296-114C>T Uncertain significance Single submitter
- CCDC74B c.296-115C>G Uncertain significance Single submitter
- CCDC74B c.296-117A>C Uncertain significance Single submitter
- CCDC74B c.296-131C>A Uncertain significance Single submitter
- CCDC74B c.296-13C>T Uncertain significance Single submitter
- CCDC74B c.296-147G>A Uncertain significance Single submitter
- CCDC74B c.296-148C>A Uncertain significance Single submitter
- CCDC74B c.296-151G>A Uncertain significance Single submitter
- CCDC74B c.296-154G>A Uncertain significance Single submitter
- CCDC74B c.296-157T>G Uncertain significance Single submitter
- CCDC74B c.296-160C>T Uncertain significance Single submitter
- CCDC74B c.296-177T>C Uncertain significance Single submitter
- CCDC74B c.296-1G>C Uncertain significance Single submitter
- CCDC74B c.296-22G>A Uncertain significance Single submitter
- CCDC74B c.296-36C>A Uncertain significance Single submitter
- CCDC74B c.296-36C>T Uncertain significance Single submitter
- CCDC74B c.296-37G>A Uncertain significance Single submitter
- CCDC74B c.296-40C>A Uncertain significance Single submitter
- CCDC74B c.296-43C>T Uncertain significance Single submitter
- CCDC74B c.296-49C>G Uncertain significance Single submitter
- CCDC74B c.296-72G>C Uncertain significance Single submitter
- CCDC74B c.296-73C>T Uncertain significance Single submitter
- CCDC74B p.Ala138Val Uncertain significance Single submitter
- CCDC74B p.Ala189Val Uncertain significance Single submitter
- CCDC74B p.Arg207Met Uncertain significance Single submitter
- CCDC74B p.Arg26Gly Uncertain significance Single submitter
- CCDC74B p.Arg307Gln Uncertain significance Single submitter
- CCDC74B p.Arg307Trp Uncertain significance Single submitter
- CCDC74B p.Arg308His Uncertain significance Single submitter
- CCDC74B p.Arg311Cys Uncertain significance Single submitter
- CCDC74B p.Arg311His Uncertain significance Single submitter
- CCDC74B p.Arg42Ser Uncertain significance Single submitter
- CCDC74B p.Arg80Trp Uncertain significance Single submitter
- CCDC74B p.Asn148His Uncertain significance Single submitter
- CCDC74B p.Asp252His Uncertain significance Single submitter
- CCDC74B p.Gln182His Uncertain significance Single submitter
- CCDC74B p.Gln185Arg Uncertain significance Single submitter
- CCDC74B p.Gln288Lys Uncertain significance Single submitter
- CCDC74B p.Gln32His Uncertain significance Single submitter
- CCDC74B p.Glu141Lys Uncertain significance Single submitter
- CCDC74B p.Glu210Lys Uncertain significance Single submitter
- CCDC74B p.Glu215Lys Uncertain significance Single submitter
- CCDC74B p.Leu101Val Uncertain significance Single submitter
- CCDC74B p.Leu221Phe Uncertain significance Single submitter
- CCDC74B p.Leu34Trp Uncertain significance Single submitter
- CCDC74B p.Leu51Gln Uncertain significance Single submitter
- CCDC74B p.Lys127Glu Uncertain significance Single submitter
- CCDC74B p.Lys150Thr Uncertain significance Single submitter
- CCDC74B p.Lys264Arg Uncertain significance Single submitter
- CCDC74B p.Lys291Glu Uncertain significance Single submitter
- CCDC74B p.Lys97Asn Uncertain significance Single submitter
- CCDC74B p.Met194Val Uncertain significance Single submitter
- CCDC74B p.Pro120Ser Uncertain significance Single submitter
- CCDC74B p.Pro120Thr Uncertain significance Single submitter
- CCDC74B p.Pro135His Uncertain significance Single submitter
- CCDC74B p.Pro135Leu Uncertain significance Single submitter
- CCDC74B p.Pro13Leu Uncertain significance Single submitter
- CCDC74B p.Pro16Ser Uncertain significance Single submitter
- CCDC74B p.Pro46Leu Uncertain significance Single submitter
- CCDC74B p.Ser108Thr Uncertain significance Single submitter
- CCDC74B p.Ser111Phe Uncertain significance Single submitter
- CCDC74B p.Ser15Leu Uncertain significance Single submitter
- CCDC74B p.Ser169Cys Uncertain significance Single submitter
- CCDC74B p.Ser267Phe Uncertain significance Single submitter
- CCDC74B p.Ser312Ala Uncertain significance Single submitter
- CCDC74B p.Ser312Leu Uncertain significance Single submitter
- CCDC74B p.Ser56Gly Uncertain significance Single submitter
- CCDC74B p.Ser65Leu Uncertain significance Single submitter
- CCDC74B p.Thr103Lys Uncertain significance Single submitter
- CCDC74B p.Val157Ile Uncertain significance Single submitter
- CCDC74B p.Val243Phe Uncertain significance Single submitter
- CCDC74B p.Val277Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CCDC74B c.296-129G>C Uncertain significance Single submitter
- CCDC74B p.Asn82Lys Uncertain significance Single submitter
- CCDC74B p.Asn82Thr Uncertain significance Single submitter
- CCDC74B p.Cys209Arg Uncertain significance Single submitter
- CCDC74B p.Gln223His Uncertain significance Single submitter
- CCDC74B p.Gln288His Uncertain significance Single submitter
- CCDC74B p.Glu296Val Uncertain significance Single submitter
- CCDC74B p.Ile282Thr Uncertain significance Single submitter
- CCDC74B p.Leu230Phe Likely benign Single submitter
- CCDC74B p.Lys83Asn Uncertain significance Single submitter
- CCDC74B p.Ser274Arg Uncertain significance Single submitter
All CCDC74B variants
Likely benign 8
- c.295+203A>G Single submitter
- c.296-105C>A Single submitter
- c.296-148C>T Single submitter
- c.296-25G>A Single submitter
- p.Ala189Gly Single submitter
- p.Arg86His Single submitter
- p.Leu230Phe Single submitter ⚠
- p.Pro290Leu Single submitter
Uncertain significance 82
- c.296-114C>T Single submitter ⚠
- c.296-115C>G Single submitter ⚠
- c.296-117A>C Single submitter ⚠
- c.296-129G>C Single submitter ⚠
- c.296-131C>A Single submitter ⚠
- c.296-13C>T Single submitter ⚠
- c.296-147G>A Single submitter ⚠
- c.296-148C>A Single submitter ⚠
- c.296-151G>A Single submitter ⚠
- c.296-154G>A Single submitter ⚠
- c.296-157T>G Single submitter ⚠
- c.296-160C>T Single submitter ⚠
- c.296-177T>C Single submitter ⚠
- c.296-1G>C Single submitter ⚠
- c.296-22G>A Single submitter ⚠
- c.296-36C>A Single submitter ⚠
- c.296-36C>T Single submitter ⚠
- c.296-37G>A Single submitter ⚠
- c.296-40C>A Single submitter ⚠
- c.296-43C>T Single submitter ⚠
- c.296-49C>G Single submitter ⚠
- c.296-72G>C Single submitter ⚠
- c.296-73C>T Single submitter ⚠
- p.Ala138Val Single submitter ⚠
- p.Ala189Val Single submitter ⚠
- p.Arg207Met Single submitter ⚠
- p.Arg26Gly Single submitter ⚠
- p.Arg307Gln Single submitter ⚠
- p.Arg307Trp Single submitter ⚠
- p.Arg308His Single submitter ⚠
- p.Arg311Cys Single submitter ⚠
- p.Arg311His Single submitter ⚠
- p.Arg42Ser Single submitter ⚠
- p.Arg80Trp Single submitter ⚠
- p.Asn148His Single submitter ⚠
- p.Asn82Lys Single submitter ⚠
- p.Asn82Thr Single submitter ⚠
- p.Asp252His Single submitter ⚠
- p.Cys209Arg Single submitter ⚠
- p.Gln182His Single submitter ⚠
- p.Gln185Arg Single submitter ⚠
- p.Gln223His Single submitter ⚠
- p.Gln288His Single submitter ⚠
- p.Gln288Lys Single submitter ⚠
- p.Gln32His Single submitter ⚠
- p.Glu141Lys Single submitter ⚠
- p.Glu210Lys Single submitter ⚠
- p.Glu215Lys Single submitter ⚠
- p.Glu296Val Single submitter ⚠
- p.Ile282Thr Single submitter ⚠
- p.Leu101Val Single submitter ⚠
- p.Leu221Phe Single submitter ⚠
- p.Leu34Trp Single submitter ⚠
- p.Leu51Gln Single submitter ⚠
- p.Lys127Glu Single submitter ⚠
- p.Lys150Thr Single submitter ⚠
- p.Lys264Arg Single submitter ⚠
- p.Lys291Glu Single submitter ⚠
- p.Lys83Asn Single submitter ⚠
- p.Lys97Asn Single submitter ⚠
- p.Met194Val Single submitter ⚠
- p.Pro120Ser Single submitter ⚠
- p.Pro120Thr Single submitter ⚠
- p.Pro135His Single submitter ⚠
- p.Pro135Leu Single submitter ⚠
- p.Pro13Leu Single submitter ⚠
- p.Pro16Ser Single submitter ⚠
- p.Pro46Leu Single submitter ⚠
- p.Ser108Thr Single submitter ⚠
- p.Ser111Phe Single submitter ⚠
- p.Ser15Leu Single submitter ⚠
- p.Ser169Cys Single submitter ⚠
- p.Ser267Phe Single submitter ⚠
- p.Ser274Arg Single submitter ⚠
- p.Ser312Ala Single submitter ⚠
- p.Ser312Leu Single submitter ⚠
- p.Ser56Gly Single submitter ⚠
- p.Ser65Leu Single submitter ⚠
- p.Thr103Lys Single submitter ⚠
- p.Val157Ile Single submitter ⚠
- p.Val243Phe Single submitter ⚠
- p.Val277Ala Single submitter ⚠