CCDC77 — 74 ClinVar variants
All ClinVar germline CCDC77 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
6 Likely benign · 68 Uncertain significance
Full CCDC77 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC77 p.Ala157Pro Uncertain significance Single submitter
- CCDC77 p.Ala194Gly Uncertain significance Single submitter
- CCDC77 p.Ala445Pro Uncertain significance Single submitter
- CCDC77 p.Arg134Leu Uncertain significance Single submitter
- CCDC77 p.Arg216Gly Uncertain significance Single submitter
- CCDC77 p.Arg318Lys Uncertain significance Single submitter
- CCDC77 p.Arg391Cys Uncertain significance Single submitter
- CCDC77 p.Arg391Pro Uncertain significance Single submitter
- CCDC77 p.Arg428Gln Uncertain significance Single submitter
- CCDC77 p.Arg48His Uncertain significance Single submitter
- CCDC77 p.Asn448Lys Uncertain significance Single submitter
- CCDC77 p.Asp156Asn Uncertain significance Single submitter
- CCDC77 p.Cys184Trp Uncertain significance Single submitter
- CCDC77 p.Cys321Tyr Uncertain significance Single submitter
- CCDC77 p.Gln316His Uncertain significance Single submitter
- CCDC77 p.Gln355Pro Uncertain significance Single submitter
- CCDC77 p.Gln90Arg Uncertain significance Single submitter
- CCDC77 p.Glu159Lys Uncertain significance Single submitter
- CCDC77 p.Glu183Asp Uncertain significance Single submitter
- CCDC77 p.Glu212Gly Uncertain significance Single submitter
- CCDC77 p.Glu456Lys Uncertain significance Single submitter
- CCDC77 p.Glu85Asp Uncertain significance Single submitter
- CCDC77 p.Gly158Arg Uncertain significance Single submitter
- CCDC77 p.Gly382Glu Uncertain significance Single submitter
- CCDC77 p.His91Pro Uncertain significance Single submitter
- CCDC77 p.Ile218Met Uncertain significance Single submitter
- CCDC77 p.Ile222Asn Uncertain significance Single submitter
- CCDC77 p.Leu282Arg Uncertain significance Single submitter
- CCDC77 p.Leu80Pro Uncertain significance Single submitter
- CCDC77 p.Leu82Phe Uncertain significance Single submitter
- CCDC77 p.Lys165Glu Uncertain significance Single submitter
- CCDC77 p.Lys267Thr Uncertain significance Single submitter
- CCDC77 p.Lys350Glu Uncertain significance Single submitter
- CCDC77 p.Lys421Glu Uncertain significance Single submitter
- CCDC77 p.Lys92Asn Uncertain significance Single submitter
- CCDC77 p.Met114Thr Uncertain significance Single submitter
- CCDC77 p.Met402Val Uncertain significance Single submitter
- CCDC77 p.Pro167Ala Uncertain significance Single submitter
- CCDC77 p.Pro333Thr Uncertain significance Single submitter
- CCDC77 p.Pro41Leu Uncertain significance Single submitter
- CCDC77 p.Pro5Ser Uncertain significance Single submitter
- CCDC77 p.Ser204Leu Uncertain significance Single submitter
- CCDC77 p.Ser239Phe Uncertain significance Single submitter
- CCDC77 p.Ser338Asn Uncertain significance Single submitter
- CCDC77 p.Ser343Arg Uncertain significance Single submitter
- CCDC77 p.Thr177Ala Uncertain significance Single submitter
- CCDC77 p.Thr40Ala Uncertain significance Single submitter
- CCDC77 p.Val181Ile Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- CCDC77 p.Arg251Gln Uncertain significance Single submitter
- CCDC77 p.Arg251Leu Uncertain significance Single submitter
- CCDC77 p.Arg251Trp Uncertain significance Single submitter
- CCDC77 p.Arg378His Uncertain significance Single submitter
- CCDC77 p.Arg405His Uncertain significance Single submitter
- CCDC77 p.Arg446Trp Uncertain significance Single submitter
- CCDC77 p.Cys367Arg Uncertain significance Single submitter
- CCDC77 p.Glu141Gln Uncertain significance Single submitter
- CCDC77 p.Ile346Asn Uncertain significance Single submitter
- CCDC77 p.Ile424Thr Uncertain significance Single submitter
- CCDC77 p.Leu111Ile Uncertain significance Single submitter
- CCDC77 p.Leu246Phe Uncertain significance Single submitter
- CCDC77 p.Leu275Phe Uncertain significance Single submitter
- CCDC77 p.Leu481Val Uncertain significance Single submitter
- CCDC77 p.Leu93Val Uncertain significance Single submitter
- CCDC77 p.Lys237Ile Uncertain significance Single submitter
- CCDC77 p.Ser25Asn Uncertain significance Single submitter
- CCDC77 p.Ser44Tyr Uncertain significance Single submitter
- CCDC77 p.Tyr317Cys Uncertain significance Single submitter
- CCDC77 p.Val225Met Uncertain significance Single submitter
All CCDC77 variants
Likely benign 6
- p.Ala157Thr Single submitter
- p.Ala34= Single submitter
- p.Arg446Gln Single submitter
- p.Leu37Val Single submitter
- p.Lys237Arg Single submitter
- p.Met33Val Single submitter
Uncertain significance 68
- p.Ala157Pro Single submitter ⚠
- p.Ala194Gly Single submitter ⚠
- p.Ala445Pro Single submitter ⚠
- p.Arg134Leu Single submitter ⚠
- p.Arg216Gly Single submitter ⚠
- p.Arg251Gln Single submitter ⚠
- p.Arg251Leu Single submitter ⚠
- p.Arg251Trp Single submitter ⚠
- p.Arg318Lys Single submitter ⚠
- p.Arg378His Single submitter ⚠
- p.Arg391Cys Single submitter ⚠
- p.Arg391Pro Single submitter ⚠
- p.Arg405His Single submitter ⚠
- p.Arg428Gln Single submitter ⚠
- p.Arg446Trp Single submitter ⚠
- p.Arg48His Single submitter ⚠
- p.Asn448Lys Single submitter ⚠
- p.Asp156Asn Single submitter ⚠
- p.Cys184Trp Single submitter ⚠
- p.Cys321Tyr Single submitter ⚠
- p.Cys367Arg Single submitter ⚠
- p.Gln316His Single submitter ⚠
- p.Gln355Pro Single submitter ⚠
- p.Gln90Arg Single submitter ⚠
- p.Glu141Gln Single submitter ⚠
- p.Glu159Lys Single submitter ⚠
- p.Glu183Asp Single submitter ⚠
- p.Glu212Gly Single submitter ⚠
- p.Glu456Lys Single submitter ⚠
- p.Glu85Asp Single submitter ⚠
- p.Gly158Arg Single submitter ⚠
- p.Gly382Glu Single submitter ⚠
- p.His91Pro Single submitter ⚠
- p.Ile218Met Single submitter ⚠
- p.Ile222Asn Single submitter ⚠
- p.Ile346Asn Single submitter ⚠
- p.Ile424Thr Single submitter ⚠
- p.Leu111Ile Single submitter ⚠
- p.Leu246Phe Single submitter ⚠
- p.Leu275Phe Single submitter ⚠
- p.Leu282Arg Single submitter ⚠
- p.Leu481Val Single submitter ⚠
- p.Leu80Pro Single submitter ⚠
- p.Leu82Phe Single submitter ⚠
- p.Leu93Val Single submitter ⚠
- p.Lys165Glu Single submitter ⚠
- p.Lys237Ile Single submitter ⚠
- p.Lys267Thr Single submitter ⚠
- p.Lys350Glu Single submitter ⚠
- p.Lys421Glu Single submitter ⚠
- p.Lys92Asn Single submitter ⚠
- p.Met114Thr Single submitter ⚠
- p.Met402Val Single submitter ⚠
- p.Pro167Ala Single submitter ⚠
- p.Pro333Thr Single submitter ⚠
- p.Pro41Leu Single submitter ⚠
- p.Pro5Ser Single submitter ⚠
- p.Ser204Leu Single submitter ⚠
- p.Ser239Phe Single submitter ⚠
- p.Ser25Asn Single submitter ⚠
- p.Ser338Asn Single submitter ⚠
- p.Ser343Arg Single submitter ⚠
- p.Ser44Tyr Single submitter ⚠
- p.Thr177Ala Single submitter ⚠
- p.Thr40Ala Single submitter ⚠
- p.Tyr317Cys Single submitter ⚠
- p.Val181Ile Single submitter ⚠
- p.Val225Met Single submitter ⚠