CCDC85A — 101 ClinVar variants
All ClinVar germline CCDC85A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 95 flagged for review →
4 Likely benign · 97 Uncertain significance
Full CCDC85A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 95
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 70
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC85A p.Ala13Val Uncertain significance Single submitter
- CCDC85A p.Ala142Ser Uncertain significance Single submitter
- CCDC85A p.Ala178Val Uncertain significance Single submitter
- CCDC85A p.Ala201Pro Uncertain significance Single submitter
- CCDC85A p.Ala201Val Uncertain significance Single submitter
- CCDC85A p.Ala21Ser Uncertain significance Single submitter
- CCDC85A p.Ala21Val Uncertain significance Single submitter
- CCDC85A p.Ala28Asp Uncertain significance Single submitter
- CCDC85A p.Ala440Ser Uncertain significance Single submitter
- CCDC85A p.Arg124Trp Uncertain significance Single submitter
- CCDC85A p.Arg263Gly Uncertain significance Single submitter
- CCDC85A p.Arg330Thr Uncertain significance Single submitter
- CCDC85A p.Arg465Trp Uncertain significance Single submitter
- CCDC85A p.Arg75His Uncertain significance Single submitter
- CCDC85A p.Arg89His Uncertain significance Single submitter
- CCDC85A p.Asn451Ser Uncertain significance Single submitter
- CCDC85A p.Asn501Lys Uncertain significance Single submitter
- CCDC85A p.Asp93Asn Uncertain significance Single submitter
- CCDC85A p.Asp93Val Uncertain significance Single submitter
- CCDC85A p.Cys194Tyr Uncertain significance Single submitter
- CCDC85A p.Cys473Trp Uncertain significance Single submitter
- CCDC85A p.Gln398Pro Uncertain significance Single submitter
- CCDC85A p.Gln96Leu Uncertain significance Single submitter
- CCDC85A p.Glu100Ala Uncertain significance Single submitter
- CCDC85A p.Glu16Gly Uncertain significance Single submitter
- CCDC85A p.Glu303Lys Uncertain significance Single submitter
- CCDC85A p.Glu42Asp Uncertain significance Single submitter
- CCDC85A p.Glu51Asp Uncertain significance Single submitter
- CCDC85A p.Gly24Arg Uncertain significance Single submitter
- CCDC85A p.Gly345Ala Uncertain significance Single submitter
- CCDC85A p.Gly345Arg Uncertain significance Single submitter
- CCDC85A p.Gly345Val Uncertain significance Single submitter
- CCDC85A p.Gly458Asp Uncertain significance Single submitter
- CCDC85A p.Gly458Val Uncertain significance Single submitter
- CCDC85A p.Gly485Arg Uncertain significance Single submitter
- CCDC85A p.Gly485Cys Uncertain significance Single submitter
- CCDC85A p.Gly6Arg Uncertain significance Single submitter
- CCDC85A p.Gly7Ser Uncertain significance Single submitter
- CCDC85A p.His258Arg Uncertain significance Single submitter
- CCDC85A p.His331Arg Uncertain significance Single submitter
- CCDC85A p.His543Asn Uncertain significance Single submitter
- CCDC85A p.Ile476Thr Uncertain significance Single submitter
- CCDC85A p.Leu196Val Uncertain significance Single submitter
- CCDC85A p.Leu237Pro Uncertain significance Single submitter
- CCDC85A p.Leu339Val Uncertain significance Single submitter
- CCDC85A p.Leu483Phe Uncertain significance Single submitter
- CCDC85A p.Leu85Pro Uncertain significance Single submitter
- CCDC85A p.Lys275Glu Uncertain significance Single submitter
- CCDC85A p.Lys38Arg Uncertain significance Single submitter
- CCDC85A p.Met436Val Uncertain significance Single submitter
- CCDC85A p.Met553Leu Uncertain significance Single submitter
- CCDC85A p.Pro234Leu Uncertain significance Single submitter
- CCDC85A p.Pro240Leu Uncertain significance Single submitter
- CCDC85A p.Pro271Thr Uncertain significance Single submitter
- CCDC85A p.Pro279Ser Uncertain significance Single submitter
- CCDC85A p.Pro290Ser Uncertain significance Single submitter
- CCDC85A p.Pro296Thr Uncertain significance Single submitter
- CCDC85A p.Pro32Leu Uncertain significance Single submitter
- CCDC85A p.Pro403Thr Uncertain significance Single submitter
- CCDC85A p.Pro484Leu Uncertain significance Single submitter
- CCDC85A p.Ser192Gly Uncertain significance Single submitter
- CCDC85A p.Ser19Phe Uncertain significance Single submitter
- CCDC85A p.Ser332Gly Uncertain significance Single submitter
- CCDC85A p.Ser502Cys Uncertain significance Single submitter
- CCDC85A p.Ser505Gly Uncertain significance Single submitter
- CCDC85A p.Ser507Asn Uncertain significance Single submitter
- CCDC85A p.Ser507Gly Uncertain significance Single submitter
- CCDC85A p.Thr267Asn Uncertain significance Single submitter
- CCDC85A p.Val408Ile Uncertain significance Single submitter
- CCDC85A p.Val466Ile Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- CCDC85A p.Ala425Val Uncertain significance Single submitter
- CCDC85A p.Arg184Cys Uncertain significance Single submitter
- CCDC85A p.Arg435Leu Uncertain significance Single submitter
- CCDC85A p.Arg54Cys Uncertain significance Single submitter
- CCDC85A p.Asp269His Uncertain significance Single submitter
- CCDC85A p.Glu257Lys Uncertain significance Single submitter
- CCDC85A p.Glu280Lys Uncertain significance Single submitter
- CCDC85A p.Glu60Gln Uncertain significance Single submitter
- CCDC85A p.Gly130Ser Uncertain significance Single submitter
- CCDC85A p.Gly345Glu Uncertain significance Single submitter
- CCDC85A p.Gly345Trp Uncertain significance Single submitter
- CCDC85A p.Gly368Glu Uncertain significance Single submitter
- CCDC85A p.His342Asp Uncertain significance Single submitter
- CCDC85A p.Lys307Met Uncertain significance Single submitter
- CCDC85A p.Met67Ile Uncertain significance Single submitter
- CCDC85A p.Pro222Arg Uncertain significance Single submitter
- CCDC85A p.Pro438Ser Uncertain significance Single submitter
- CCDC85A p.Ser189Thr Uncertain significance Single submitter
- CCDC85A p.Ser25Trp Uncertain significance Single submitter
- CCDC85A p.Ser278Arg Uncertain significance Single submitter
- CCDC85A p.Ser2Trp Uncertain significance Single submitter
- CCDC85A p.Ser335Ile Uncertain significance Single submitter
- CCDC85A p.Trp469Cys Uncertain significance Single submitter
- CCDC85A p.Tyr132His Uncertain significance Single submitter
- CCDC85A p.Val427Leu Uncertain significance Single submitter
All CCDC85A variants
Likely benign 4
- p.Ala254Thr Single submitter
- p.Arg270His Single submitter
- p.Gly383= Single submitter
- p.Pro256= Single submitter
Uncertain significance 97
- p.Ala13Val Single submitter ⚠
- p.Ala142Ser Single submitter ⚠
- p.Ala178Val Single submitter ⚠
- p.Ala201Pro Single submitter ⚠
- p.Ala201Val Single submitter ⚠
- p.Ala21Ser Single submitter ⚠
- p.Ala21Val Single submitter ⚠
- p.Ala28Asp Single submitter ⚠
- p.Ala425Val Single submitter ⚠
- p.Ala440Ser Single submitter ⚠
- p.Arg124Trp Single submitter ⚠
- p.Arg184Cys Single submitter ⚠
- p.Arg263Gly Single submitter ⚠
- p.Arg330Thr Single submitter ⚠
- p.Arg435Leu Single submitter ⚠
- p.Arg465Trp Single submitter ⚠
- p.Arg54Cys Single submitter ⚠
- p.Arg75His Single submitter ⚠
- p.Arg89His Single submitter ⚠
- p.Asn451Ser Single submitter ⚠
- p.Asn501Lys Single submitter ⚠
- p.Asp269His Single submitter ⚠
- p.Asp35Glu Single submitter
- p.Asp93Asn Single submitter ⚠
- p.Asp93Val Single submitter ⚠
- p.Cys194Tyr Single submitter ⚠
- p.Cys473Trp Single submitter ⚠
- p.Gln398Pro Single submitter ⚠
- p.Gln96Leu Single submitter ⚠
- p.Glu100Ala Single submitter ⚠
- p.Glu16Gly Single submitter ⚠
- p.Glu257Lys Single submitter ⚠
- p.Glu280Lys Single submitter ⚠
- p.Glu303Lys Single submitter ⚠
- p.Glu42Asp Single submitter ⚠
- p.Glu51Asp Single submitter ⚠
- p.Glu60Gln Single submitter ⚠
- p.Gly130Ser Single submitter ⚠
- p.Gly24Arg Single submitter ⚠
- p.Gly345Ala Single submitter ⚠
- p.Gly345Arg Single submitter ⚠
- p.Gly345Glu Single submitter ⚠
- p.Gly345Trp Single submitter ⚠
- p.Gly345Val Single submitter ⚠
- p.Gly368Glu Single submitter ⚠
- p.Gly458Asp Single submitter ⚠
- p.Gly458Val Single submitter ⚠
- p.Gly485Arg Single submitter ⚠
- p.Gly485Cys Single submitter ⚠
- p.Gly6Arg Single submitter ⚠
- p.Gly7Ser Single submitter ⚠
- p.His258Arg Single submitter ⚠
- p.His331Arg Single submitter ⚠
- p.His342Asp Single submitter ⚠
- p.His543Asn Single submitter ⚠
- p.Ile476Thr Single submitter ⚠
- p.Leu196Val Single submitter ⚠
- p.Leu237Pro Single submitter ⚠
- p.Leu339Val Single submitter ⚠
- p.Leu483Phe Single submitter ⚠
- p.Leu85Pro Single submitter ⚠
- p.Lys275Glu Single submitter ⚠
- p.Lys307Met Single submitter ⚠
- p.Lys38Arg Single submitter ⚠
- p.Met436Val Single submitter ⚠
- p.Met553Leu Single submitter ⚠
- p.Met67Ile Single submitter ⚠
- p.Pro222Arg Single submitter ⚠
- p.Pro234Leu Single submitter ⚠
- p.Pro240Leu Single submitter ⚠
- p.Pro271Thr Single submitter ⚠
- p.Pro279Ser Single submitter ⚠
- p.Pro290Ser Single submitter ⚠
- p.Pro296Thr Single submitter ⚠
- p.Pro32Leu Single submitter ⚠
- p.Pro403Thr Single submitter ⚠
- p.Pro438Ser Single submitter ⚠
- p.Pro484Leu Single submitter ⚠
- p.Ser189Thr Single submitter ⚠
- p.Ser192Gly Single submitter ⚠
- p.Ser19Phe Single submitter ⚠
- p.Ser25Trp Single submitter ⚠
- p.Ser278Arg Single submitter ⚠
- p.Ser2Trp Single submitter ⚠
- p.Ser332Gly Single submitter ⚠
- p.Ser335Ile Single submitter ⚠
- p.Ser502Cys Single submitter ⚠
- p.Ser505Gly Single submitter ⚠
- p.Ser507Asn Single submitter ⚠
- p.Ser507Gly Single submitter ⚠
- p.Ser536Pro Single submitter
- p.Thr267Asn Single submitter ⚠
- p.Trp469Cys Single submitter ⚠
- p.Tyr132His Single submitter ⚠
- p.Val408Ile Single submitter ⚠
- p.Val427Leu Single submitter ⚠
- p.Val466Ile Single submitter ⚠