CCDC85B — 17 ClinVar variants
All ClinVar germline CCDC85B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
17 Uncertain significance
Full CCDC85B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC85B p.Ala143Val Uncertain significance Single submitter
- CCDC85B p.Arg61Leu Uncertain significance Single submitter
- CCDC85B p.Arg68Gly Uncertain significance Single submitter
- CCDC85B p.Asp201Asn Uncertain significance Single submitter
- CCDC85B p.Gln193Leu Uncertain significance Single submitter
- CCDC85B p.Glu62Asp Uncertain significance Single submitter
- CCDC85B p.Gly152Ser Uncertain significance Single submitter
- CCDC85B p.Pro172Ala Uncertain significance Single submitter
- CCDC85B p.Pro172Leu Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- CCDC85B p.Arg107Gln Uncertain significance Single submitter
- CCDC85B p.Arg96Leu Uncertain significance Single submitter
- CCDC85B p.Asn67Ser Uncertain significance Single submitter
- CCDC85B p.Cys198Arg Uncertain significance Single submitter
- CCDC85B p.Glu23Asp Uncertain significance Single submitter
- CCDC85B p.Gly159Val Uncertain significance Single submitter
- CCDC85B p.Leu66Phe Uncertain significance Single submitter
- CCDC85B p.Ser199Phe Uncertain significance Single submitter
All CCDC85B variants
Uncertain significance 17
- p.Ala143Val Single submitter ⚠
- p.Arg107Gln Single submitter ⚠
- p.Arg61Leu Single submitter ⚠
- p.Arg68Gly Single submitter ⚠
- p.Arg96Leu Single submitter ⚠
- p.Asn67Ser Single submitter ⚠
- p.Asp201Asn Single submitter ⚠
- p.Cys198Arg Single submitter ⚠
- p.Gln193Leu Single submitter ⚠
- p.Glu23Asp Single submitter ⚠
- p.Glu62Asp Single submitter ⚠
- p.Gly152Ser Single submitter ⚠
- p.Gly159Val Single submitter ⚠
- p.Leu66Phe Single submitter ⚠
- p.Pro172Ala Single submitter ⚠
- p.Pro172Leu Single submitter ⚠
- p.Ser199Phe Single submitter ⚠