CCDC85C — 74 ClinVar variants
All ClinVar germline CCDC85C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
6 Likely benign · 68 Uncertain significance
Full CCDC85C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC85C p.Ala156Thr Uncertain significance Single submitter
- CCDC85C p.Ala235Thr Uncertain significance Single submitter
- CCDC85C p.Ala288Ser Uncertain significance Single submitter
- CCDC85C p.Ala288Thr Uncertain significance Single submitter
- CCDC85C p.Ala32Val Uncertain significance Single submitter
- CCDC85C p.Ala331Thr Uncertain significance Single submitter
- CCDC85C p.Arg103Leu Uncertain significance Single submitter
- CCDC85C p.Arg110Cys Uncertain significance Single submitter
- CCDC85C p.Arg110Leu Uncertain significance Single submitter
- CCDC85C p.Arg244Cys Uncertain significance Single submitter
- CCDC85C p.Arg244Pro Uncertain significance Single submitter
- CCDC85C p.Glu146Lys Uncertain significance Single submitter
- CCDC85C p.Glu14Val Uncertain significance Single submitter
- CCDC85C p.Glu360Asp Uncertain significance Single submitter
- CCDC85C p.Glu375Asp Uncertain significance Single submitter
- CCDC85C p.Glu86Gly Uncertain significance Single submitter
- CCDC85C p.Gly231Arg Uncertain significance Single submitter
- CCDC85C p.His222Gln Uncertain significance Single submitter
- CCDC85C p.His256Tyr Uncertain significance Single submitter
- CCDC85C p.Leu24Gln Uncertain significance Single submitter
- CCDC85C p.Lys239Arg Uncertain significance Single submitter
- CCDC85C p.Lys3Asn Uncertain significance Single submitter
- CCDC85C p.Pro189Gln Uncertain significance Single submitter
- CCDC85C p.Pro224Leu Uncertain significance Single submitter
- CCDC85C p.Pro225Leu Uncertain significance Single submitter
- CCDC85C p.Pro230Ala Uncertain significance Single submitter
- CCDC85C p.Pro332Arg Uncertain significance Single submitter
- CCDC85C p.Pro338Arg Uncertain significance Single submitter
- CCDC85C p.Ser268Ala Uncertain significance Single submitter
- CCDC85C p.Ser372Thr Uncertain significance Single submitter
- CCDC85C p.Thr7Pro Uncertain significance Single submitter
- CCDC85C p.Tyr342Cys Uncertain significance Single submitter
- CCDC85C p.Val116Met Uncertain significance Single submitter
Predictors split 35
The independent predictors disagree with each other — read with care.
- CCDC85C p.Ala102Val Uncertain significance Single submitter
- CCDC85C p.Ala11Ser Uncertain significance Single submitter
- CCDC85C p.Ala156Val Uncertain significance Single submitter
- CCDC85C p.Ala157Val Uncertain significance Single submitter
- CCDC85C p.Ala199Val Uncertain significance Single submitter
- CCDC85C p.Ala32Thr Uncertain significance Single submitter
- CCDC85C p.Ala9Ser Uncertain significance Single submitter
- CCDC85C p.Arg107Leu Uncertain significance Single submitter
- CCDC85C p.Arg139Leu Uncertain significance Single submitter
- CCDC85C p.Arg297Cys Uncertain significance Single submitter
- CCDC85C p.Arg407Trp Uncertain significance Single submitter
- CCDC85C p.Arg54His Uncertain significance Single submitter
- CCDC85C p.Asp72Gly Uncertain significance Single submitter
- CCDC85C p.Asp79Asn Uncertain significance Single submitter
- CCDC85C p.Cys89Ser Uncertain significance Single submitter
- CCDC85C p.Gln82Arg Uncertain significance Single submitter
- CCDC85C p.Glu153Gly Uncertain significance Single submitter
- CCDC85C p.Glu363Lys Uncertain significance Single submitter
- CCDC85C p.Gly166Ser Uncertain significance Single submitter
- CCDC85C p.Gly171Arg Uncertain significance Single submitter
- CCDC85C p.Gly172Asp Uncertain significance Single submitter
- CCDC85C p.His222Asp Uncertain significance Single submitter
- CCDC85C p.Leu312Val Uncertain significance Single submitter
- CCDC85C p.Lys416Gln Uncertain significance Single submitter
- CCDC85C p.Pro225Thr Uncertain significance Single submitter
- CCDC85C p.Pro330Leu Uncertain significance Single submitter
- CCDC85C p.Pro418Ser Uncertain significance Single submitter
- CCDC85C p.Pro418Thr Uncertain significance Single submitter
- CCDC85C p.Pro4Leu Uncertain significance Single submitter
- CCDC85C p.Ser258Asn Uncertain significance Single submitter
- CCDC85C p.Ser308Leu Uncertain significance Single submitter
- CCDC85C p.Ser372Ile Uncertain significance Single submitter
- CCDC85C p.Ser378Arg Uncertain significance Single submitter
- CCDC85C p.Ser411Phe Uncertain significance Single submitter
- CCDC85C p.Thr298Met Uncertain significance Single submitter
All CCDC85C variants
Likely benign 6
- p.Ala313Ser Single submitter
- p.Arg297= Single submitter
- p.His63= Single submitter
- p.Pro327Leu Single submitter
- p.Pro338= Single submitter
- p.Pro344Ser Single submitter
Uncertain significance 68
- p.Ala102Val Single submitter ⚠
- p.Ala11Ser Single submitter ⚠
- p.Ala156Thr Single submitter ⚠
- p.Ala156Val Single submitter ⚠
- p.Ala157Val Single submitter ⚠
- p.Ala199Val Single submitter ⚠
- p.Ala235Thr Single submitter ⚠
- p.Ala288Ser Single submitter ⚠
- p.Ala288Thr Single submitter ⚠
- p.Ala32Thr Single submitter ⚠
- p.Ala32Val Single submitter ⚠
- p.Ala331Thr Single submitter ⚠
- p.Ala9Ser Single submitter ⚠
- p.Arg103Leu Single submitter ⚠
- p.Arg107Leu Single submitter ⚠
- p.Arg110Cys Single submitter ⚠
- p.Arg110Leu Single submitter ⚠
- p.Arg139Leu Single submitter ⚠
- p.Arg244Cys Single submitter ⚠
- p.Arg244Pro Single submitter ⚠
- p.Arg297Cys Single submitter ⚠
- p.Arg407Trp Single submitter ⚠
- p.Arg54His Single submitter ⚠
- p.Asp72Gly Single submitter ⚠
- p.Asp79Asn Single submitter ⚠
- p.Cys89Ser Single submitter ⚠
- p.Gln82Arg Single submitter ⚠
- p.Glu146Lys Single submitter ⚠
- p.Glu14Val Single submitter ⚠
- p.Glu153Gly Single submitter ⚠
- p.Glu360Asp Single submitter ⚠
- p.Glu363Lys Single submitter ⚠
- p.Glu375Asp Single submitter ⚠
- p.Glu86Gly Single submitter ⚠
- p.Gly166Ser Single submitter ⚠
- p.Gly171Arg Single submitter ⚠
- p.Gly172Asp Single submitter ⚠
- p.Gly231Arg Single submitter ⚠
- p.His222Asp Single submitter ⚠
- p.His222Gln Single submitter ⚠
- p.His256Tyr Single submitter ⚠
- p.Leu24Gln Single submitter ⚠
- p.Leu312Val Single submitter ⚠
- p.Lys239Arg Single submitter ⚠
- p.Lys3Asn Single submitter ⚠
- p.Lys416Gln Single submitter ⚠
- p.Pro189Gln Single submitter ⚠
- p.Pro224Leu Single submitter ⚠
- p.Pro225Leu Single submitter ⚠
- p.Pro225Thr Single submitter ⚠
- p.Pro230Ala Single submitter ⚠
- p.Pro330Leu Single submitter ⚠
- p.Pro332Arg Single submitter ⚠
- p.Pro338Arg Single submitter ⚠
- p.Pro418Ser Single submitter ⚠
- p.Pro418Thr Single submitter ⚠
- p.Pro4Leu Single submitter ⚠
- p.Ser258Asn Single submitter ⚠
- p.Ser268Ala Single submitter ⚠
- p.Ser308Leu Single submitter ⚠
- p.Ser372Ile Single submitter ⚠
- p.Ser372Thr Single submitter ⚠
- p.Ser378Arg Single submitter ⚠
- p.Ser411Phe Single submitter ⚠
- p.Thr298Met Single submitter ⚠
- p.Thr7Pro Single submitter ⚠
- p.Tyr342Cys Single submitter ⚠
- p.Val116Met Single submitter ⚠