CCDC86 — 67 ClinVar variants
All ClinVar germline CCDC86 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
3 Likely benign · 64 Uncertain significance
Full CCDC86 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC86 p.Ala139Thr Uncertain significance Single submitter
- CCDC86 p.Ala139Val Uncertain significance Single submitter
- CCDC86 p.Ala149Gly Uncertain significance Single submitter
- CCDC86 p.Ala149Thr Uncertain significance Single submitter
- CCDC86 p.Ala169Gly Uncertain significance Single submitter
- CCDC86 p.Ala358Pro Uncertain significance Single submitter
- CCDC86 p.Ala89Thr Uncertain significance Single submitter
- CCDC86 p.Arg249His Uncertain significance Single submitter
- CCDC86 p.Arg274Pro Uncertain significance Single submitter
- CCDC86 p.Arg301Cys Uncertain significance Single submitter
- CCDC86 p.Arg30Leu Uncertain significance Single submitter
- CCDC86 p.Arg330Trp Uncertain significance Single submitter
- CCDC86 p.Arg342Gln Uncertain significance Single submitter
- CCDC86 p.Arg94Gly Uncertain significance Single submitter
- CCDC86 p.Asp2Ala Uncertain significance Single submitter
- CCDC86 p.Glu20Gly Uncertain significance Single submitter
- CCDC86 p.Gly171Asp Uncertain significance Single submitter
- CCDC86 p.Gly191Val Uncertain significance Single submitter
- CCDC86 p.Gly202Ala Uncertain significance Single submitter
- CCDC86 p.Ile339Thr Uncertain significance Single submitter
- CCDC86 p.Leu347Pro Uncertain significance Single submitter
- CCDC86 p.Lys212Gln Uncertain significance Single submitter
- CCDC86 p.Pro155Leu Uncertain significance Single submitter
- CCDC86 p.Pro158Ser Uncertain significance Single submitter
- CCDC86 p.Pro16Leu Uncertain significance Single submitter
- CCDC86 p.Pro189Ser Uncertain significance Single submitter
- CCDC86 p.Pro195Ser Uncertain significance Single submitter
- CCDC86 p.Pro198Ser Uncertain significance Single submitter
- CCDC86 p.Pro19Ser Uncertain significance Single submitter
- CCDC86 p.Thr204Ala Uncertain significance Single submitter
Predictors split 35
The independent predictors disagree with each other — read with care.
- CCDC86 p.Ala169Pro Uncertain significance Single submitter
- CCDC86 p.Arg269Trp Uncertain significance Single submitter
- CCDC86 p.Arg285His Uncertain significance Single submitter
- CCDC86 p.Arg294Cys Uncertain significance Single submitter
- CCDC86 p.Arg294His Uncertain significance Single submitter
- CCDC86 p.Arg301His Uncertain significance Single submitter
- CCDC86 p.Arg302Gln Uncertain significance Single submitter
- CCDC86 p.Arg309Cys Uncertain significance Single submitter
- CCDC86 p.Arg309His Uncertain significance Single submitter
- CCDC86 p.Arg30Gln Uncertain significance Single submitter
- CCDC86 p.Arg314Trp Uncertain significance Single submitter
- CCDC86 p.Arg323Gln Uncertain significance Single submitter
- CCDC86 p.Arg330Gly Uncertain significance Single submitter
- CCDC86 p.Arg330Leu Uncertain significance Single submitter
- CCDC86 p.Arg337Cys Uncertain significance Single submitter
- CCDC86 p.Arg337His Uncertain significance Single submitter
- CCDC86 p.Arg53Trp Uncertain significance Single submitter
- CCDC86 p.Cys116Phe Uncertain significance Single submitter
- CCDC86 p.Gln106Leu Uncertain significance Single submitter
- CCDC86 p.Gln151Arg Likely benign Single submitter
- CCDC86 p.Gln82Glu Uncertain significance Single submitter
- CCDC86 p.Gln93His Uncertain significance Single submitter
- CCDC86 p.Glu173Val Uncertain significance Single submitter
- CCDC86 p.Lys239Asn Uncertain significance Single submitter
- CCDC86 p.Lys272Arg Uncertain significance Single submitter
- CCDC86 p.Lys291Glu Uncertain significance Single submitter
- CCDC86 p.Lys359Glu Uncertain significance Single submitter
- CCDC86 p.Pro103Leu Uncertain significance Single submitter
- CCDC86 p.Pro147Leu Uncertain significance Single submitter
- CCDC86 p.Pro186Ser Uncertain significance Single submitter
- CCDC86 p.Pro356Leu Uncertain significance Single submitter
- CCDC86 p.Ser50Cys Uncertain significance Single submitter
- CCDC86 p.Thr182Ile Uncertain significance Single submitter
- CCDC86 p.Thr23Ile Uncertain significance Single submitter
- CCDC86 p.Val321Leu Uncertain significance Single submitter
All CCDC86 variants
Likely benign 3
- p.Gln151Arg Single submitter ⚠
- p.Glu36Gln Single submitter
- p.Pro352= Single submitter
Uncertain significance 64
- p.Ala139Thr Single submitter ⚠
- p.Ala139Val Single submitter ⚠
- p.Ala149Gly Single submitter ⚠
- p.Ala149Thr Single submitter ⚠
- p.Ala169Gly Single submitter ⚠
- p.Ala169Pro Single submitter ⚠
- p.Ala358Pro Single submitter ⚠
- p.Ala89Thr Single submitter ⚠
- p.Arg249His Single submitter ⚠
- p.Arg269Trp Single submitter ⚠
- p.Arg274Pro Single submitter ⚠
- p.Arg285His Single submitter ⚠
- p.Arg294Cys Single submitter ⚠
- p.Arg294His Single submitter ⚠
- p.Arg301Cys Single submitter ⚠
- p.Arg301His Single submitter ⚠
- p.Arg302Gln Single submitter ⚠
- p.Arg309Cys Single submitter ⚠
- p.Arg309His Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg30Leu Single submitter ⚠
- p.Arg314Trp Single submitter ⚠
- p.Arg323Gln Single submitter ⚠
- p.Arg330Gly Single submitter ⚠
- p.Arg330Leu Single submitter ⚠
- p.Arg330Trp Single submitter ⚠
- p.Arg337Cys Single submitter ⚠
- p.Arg337His Single submitter ⚠
- p.Arg342Gln Single submitter ⚠
- p.Arg53Trp Single submitter ⚠
- p.Arg94Gly Single submitter ⚠
- p.Asp2Ala Single submitter ⚠
- p.Cys116Phe Single submitter ⚠
- p.Gln106Leu Single submitter ⚠
- p.Gln82Glu Single submitter ⚠
- p.Gln93His Single submitter ⚠
- p.Glu173Val Single submitter ⚠
- p.Glu20Gly Single submitter ⚠
- p.Gly171Asp Single submitter ⚠
- p.Gly191Val Single submitter ⚠
- p.Gly202Ala Single submitter ⚠
- p.Ile339Thr Single submitter ⚠
- p.Leu347Pro Single submitter ⚠
- p.Lys212Gln Single submitter ⚠
- p.Lys239Asn Single submitter ⚠
- p.Lys272Arg Single submitter ⚠
- p.Lys291Glu Single submitter ⚠
- p.Lys359Glu Single submitter ⚠
- p.Pro103Leu Single submitter ⚠
- p.Pro147Leu Single submitter ⚠
- p.Pro155Leu Single submitter ⚠
- p.Pro158Ser Single submitter ⚠
- p.Pro16Leu Single submitter ⚠
- p.Pro186Ser Single submitter ⚠
- p.Pro189Ser Single submitter ⚠
- p.Pro195Ser Single submitter ⚠
- p.Pro198Ser Single submitter ⚠
- p.Pro19Ser Single submitter ⚠
- p.Pro356Leu Single submitter ⚠
- p.Ser50Cys Single submitter ⚠
- p.Thr182Ile Single submitter ⚠
- p.Thr204Ala Single submitter ⚠
- p.Thr23Ile Single submitter ⚠
- p.Val321Leu Single submitter ⚠