CCDC89 — 52 ClinVar variants
All ClinVar germline CCDC89 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
52 Uncertain significance
Full CCDC89 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC89 p.Ala114Val Uncertain significance Single submitter
- CCDC89 p.Ala201Val Uncertain significance Single submitter
- CCDC89 p.Arg22Cys Uncertain significance Single submitter
- CCDC89 p.Arg2Lys Uncertain significance Single submitter
- CCDC89 p.Arg60Met Uncertain significance Single submitter
- CCDC89 p.Asp15Asn Uncertain significance Single submitter
- CCDC89 p.Asp306Glu Uncertain significance Single submitter
- CCDC89 p.Gln205Glu Uncertain significance Single submitter
- CCDC89 p.Gln277Glu Uncertain significance Single submitter
- CCDC89 p.Glu173Gln Uncertain significance Single submitter
- CCDC89 p.Glu301Lys Uncertain significance Single submitter
- CCDC89 p.Ile79Asn Uncertain significance Single submitter
- CCDC89 p.Ile93Met Uncertain significance Single submitter
- CCDC89 p.Leu159Gln Uncertain significance Single submitter
- CCDC89 p.Leu164Ile Uncertain significance Single submitter
- CCDC89 p.Lys368Arg Uncertain significance Single submitter
- CCDC89 p.Met105Leu Uncertain significance Single submitter
- CCDC89 p.Met5Val Uncertain significance Single submitter
- CCDC89 p.Pro17Gln Uncertain significance Single submitter
- CCDC89 p.Pro17Leu Uncertain significance Single submitter
- CCDC89 p.Pro19Ala Uncertain significance Single submitter
- CCDC89 p.Ser348Tyr Uncertain significance Single submitter
- CCDC89 p.Ser84Ala Uncertain significance Single submitter
- CCDC89 p.Ser84Leu Uncertain significance Single submitter
- CCDC89 p.Thr16Ala Uncertain significance Single submitter
- CCDC89 p.Thr187Ser Uncertain significance Single submitter
- CCDC89 p.Thr192Ser Uncertain significance Single submitter
- CCDC89 p.Thr253Lys Uncertain significance Single submitter
- CCDC89 p.Thr37Ala Uncertain significance Single submitter
- CCDC89 p.Val285Glu Uncertain significance Single submitter
- CCDC89 p.Val285Met Uncertain significance Single submitter
- CCDC89 p.Val334Ala Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- CCDC89 p.Arg182Trp Uncertain significance Single submitter
- CCDC89 p.Arg207Cys Uncertain significance Single submitter
- CCDC89 p.Arg207His Uncertain significance Single submitter
- CCDC89 p.Arg313Gln Uncertain significance Single submitter
- CCDC89 p.Arg69Cys Uncertain significance Single submitter
- CCDC89 p.Arg69Leu Uncertain significance Single submitter
- CCDC89 p.Asp342Asn Uncertain significance Single submitter
- CCDC89 p.Cys183Tyr Uncertain significance Single submitter
- CCDC89 p.Gln246His Uncertain significance Single submitter
- CCDC89 p.Glu134Gly Uncertain significance Single submitter
- CCDC89 p.Glu152Lys Uncertain significance Single submitter
- CCDC89 p.Glu155Lys Uncertain significance Single submitter
- CCDC89 p.Glu208Asp Uncertain significance Single submitter
- CCDC89 p.Glu273Lys Uncertain significance Single submitter
- CCDC89 p.Glu343Gly Uncertain significance Single submitter
- CCDC89 p.Leu137Phe Uncertain significance Single submitter
- CCDC89 p.Leu311Pro Uncertain significance Single submitter
- CCDC89 p.Leu369Phe Uncertain significance Single submitter
- CCDC89 p.Phe314Cys Uncertain significance Single submitter
- CCDC89 p.Ser68Phe Uncertain significance Single submitter
All CCDC89 variants
Uncertain significance 52
- p.Ala114Val Single submitter ⚠
- p.Ala201Val Single submitter ⚠
- p.Arg182Trp Single submitter ⚠
- p.Arg207Cys Single submitter ⚠
- p.Arg207His Single submitter ⚠
- p.Arg22Cys Single submitter ⚠
- p.Arg2Lys Single submitter ⚠
- p.Arg313Gln Single submitter ⚠
- p.Arg60Met Single submitter ⚠
- p.Arg69Cys Single submitter ⚠
- p.Arg69Leu Single submitter ⚠
- p.Asp15Asn Single submitter ⚠
- p.Asp306Glu Single submitter ⚠
- p.Asp342Asn Single submitter ⚠
- p.Cys183Tyr Single submitter ⚠
- p.Gln205Glu Single submitter ⚠
- p.Gln246His Single submitter ⚠
- p.Gln277Glu Single submitter ⚠
- p.Glu134Gly Single submitter ⚠
- p.Glu152Lys Single submitter ⚠
- p.Glu155Lys Single submitter ⚠
- p.Glu173Gln Single submitter ⚠
- p.Glu208Asp Single submitter ⚠
- p.Glu273Lys Single submitter ⚠
- p.Glu301Lys Single submitter ⚠
- p.Glu343Gly Single submitter ⚠
- p.Ile79Asn Single submitter ⚠
- p.Ile93Met Single submitter ⚠
- p.Leu137Phe Single submitter ⚠
- p.Leu159Gln Single submitter ⚠
- p.Leu164Ile Single submitter ⚠
- p.Leu311Pro Single submitter ⚠
- p.Leu369Phe Single submitter ⚠
- p.Lys368Arg Single submitter ⚠
- p.Met105Leu Single submitter ⚠
- p.Met5Val Single submitter ⚠
- p.Phe314Cys Single submitter ⚠
- p.Pro17Gln Single submitter ⚠
- p.Pro17Leu Single submitter ⚠
- p.Pro19Ala Single submitter ⚠
- p.Ser348Tyr Single submitter ⚠
- p.Ser68Phe Single submitter ⚠
- p.Ser84Ala Single submitter ⚠
- p.Ser84Leu Single submitter ⚠
- p.Thr16Ala Single submitter ⚠
- p.Thr187Ser Single submitter ⚠
- p.Thr192Ser Single submitter ⚠
- p.Thr253Lys Single submitter ⚠
- p.Thr37Ala Single submitter ⚠
- p.Val285Glu Single submitter ⚠
- p.Val285Met Single submitter ⚠
- p.Val334Ala Single submitter ⚠