CCDC9 — 127 ClinVar variants
All ClinVar germline CCDC9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 124 flagged for review →
4 Likely benign · 123 Uncertain significance
Full CCDC9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 124
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC9 p.Ala322Val Uncertain significance Single submitter
- CCDC9 p.Ala356Ser Uncertain significance Single submitter
- CCDC9 p.Ala360Val Uncertain significance Single submitter
- CCDC9 p.Ala405Val Uncertain significance Single submitter
- CCDC9 p.Ala455Val Uncertain significance Single submitter
- CCDC9 p.Ala525Ser Uncertain significance Single submitter
- CCDC9 p.Arg102Gln Uncertain significance Single submitter
- CCDC9 p.Arg110His Uncertain significance Single submitter
- CCDC9 p.Arg151His Uncertain significance Single submitter
- CCDC9 p.Arg160His Uncertain significance Single submitter
- CCDC9 p.Arg192Trp Uncertain significance Single submitter
- CCDC9 p.Arg210Trp Uncertain significance Single submitter
- CCDC9 p.Arg213Trp Uncertain significance Single submitter
- CCDC9 p.Arg242His Uncertain significance Single submitter
- CCDC9 p.Arg243Gln Uncertain significance Single submitter
- CCDC9 p.Arg259Trp Uncertain significance Single submitter
- CCDC9 p.Arg261Leu Uncertain significance Single submitter
- CCDC9 p.Arg281Gly Uncertain significance Single submitter
- CCDC9 p.Arg344Ser Uncertain significance Single submitter
- CCDC9 p.Arg359Gly Uncertain significance Single submitter
- CCDC9 p.Arg367Cys Uncertain significance Single submitter
- CCDC9 p.Arg512Gln Uncertain significance Single submitter
- CCDC9 p.Asn509Ser Uncertain significance Single submitter
- CCDC9 p.Asn73Lys Uncertain significance Single submitter
- CCDC9 p.Asp145Gly Uncertain significance Single submitter
- CCDC9 p.Asp430Gly Uncertain significance Single submitter
- CCDC9 p.Cys462Tyr Uncertain significance Single submitter
- CCDC9 p.Gln353Arg Uncertain significance Single submitter
- CCDC9 p.Gln98Arg Uncertain significance Single submitter
- CCDC9 p.Glu372Asp Uncertain significance Single submitter
- CCDC9 p.Glu388Gln Uncertain significance Single submitter
- CCDC9 p.Gly203Arg Uncertain significance Single submitter
- CCDC9 p.Gly220Ser Uncertain significance Single submitter
- CCDC9 p.Gly418Glu Uncertain significance Single submitter
- CCDC9 p.Gly441Ser Uncertain significance Single submitter
- CCDC9 p.Gly92Arg Uncertain significance Single submitter
- CCDC9 p.Gly93Ser Uncertain significance Single submitter
- CCDC9 p.His310Arg Uncertain significance Single submitter
- CCDC9 p.His364Arg Uncertain significance Single submitter
- CCDC9 p.Ile148Val Uncertain significance Single submitter
- CCDC9 p.Ile427Leu Uncertain significance Single submitter
- CCDC9 p.Leu140Phe Uncertain significance Single submitter
- CCDC9 p.Leu235Phe Uncertain significance Single submitter
- CCDC9 p.Lys303Gln Uncertain significance Single submitter
- CCDC9 p.Lys392Arg Uncertain significance Single submitter
- CCDC9 p.Met105Ile Uncertain significance Single submitter
- CCDC9 p.Met105Val Uncertain significance Single submitter
- CCDC9 p.Met252Val Uncertain significance Single submitter
- CCDC9 p.Pro138Ser Uncertain significance Single submitter
- CCDC9 p.Pro204Ser Uncertain significance Single submitter
- CCDC9 p.Pro226Leu Uncertain significance Single submitter
- CCDC9 p.Pro325Ser Uncertain significance Single submitter
- CCDC9 p.Pro377Ser Uncertain significance Single submitter
- CCDC9 p.Pro399Arg Uncertain significance Single submitter
- CCDC9 p.Pro404Ser Uncertain significance Single submitter
- CCDC9 p.Pro453Ser Uncertain significance Single submitter
- CCDC9 p.Pro457Leu Uncertain significance Single submitter
- CCDC9 p.Pro470Leu Uncertain significance Single submitter
- CCDC9 p.Pro470Ser Uncertain significance Single submitter
- CCDC9 p.Pro473Gln Uncertain significance Single submitter
- CCDC9 p.Pro480Ser Uncertain significance Single submitter
- CCDC9 p.Ser208Thr Uncertain significance Single submitter
- CCDC9 p.Ser349Asn Uncertain significance Single submitter
- CCDC9 p.Thr329Ala Uncertain significance Single submitter
- CCDC9 p.Thr83Pro Uncertain significance Single submitter
- CCDC9 p.Val185Phe Uncertain significance Single submitter
- CCDC9 p.Val66Leu Uncertain significance Single submitter
Predictors split 57
The independent predictors disagree with each other — read with care.
- CCDC9 p.Ala15Val Uncertain significance Single submitter
- CCDC9 p.Ala175Thr Uncertain significance Single submitter
- CCDC9 p.Arg102Trp Uncertain significance Single submitter
- CCDC9 p.Arg121Gln Uncertain significance Single submitter
- CCDC9 p.Arg128Cys Uncertain significance Single submitter
- CCDC9 p.Arg130Trp Uncertain significance Single submitter
- CCDC9 p.Arg133Trp Uncertain significance Single submitter
- CCDC9 p.Arg135Gln Uncertain significance Single submitter
- CCDC9 p.Arg151Cys Uncertain significance Single submitter
- CCDC9 p.Arg200Gln Uncertain significance Single submitter
- CCDC9 p.Arg201His Uncertain significance Single submitter
- CCDC9 p.Arg217Cys Uncertain significance Single submitter
- CCDC9 p.Arg217His Uncertain significance Single submitter
- CCDC9 p.Arg218Trp Uncertain significance Single submitter
- CCDC9 p.Arg232Cys Uncertain significance Single submitter
- CCDC9 p.Arg315Cys Uncertain significance Single submitter
- CCDC9 p.Arg33Gln Uncertain significance Single submitter
- CCDC9 p.Arg344Cys Uncertain significance Single submitter
- CCDC9 p.Arg346Met Uncertain significance Single submitter
- CCDC9 p.Arg351Trp Uncertain significance Single submitter
- CCDC9 p.Arg407Trp Uncertain significance Single submitter
- CCDC9 p.Arg512Trp Uncertain significance Single submitter
- CCDC9 p.Arg56Gln Uncertain significance Single submitter
- CCDC9 p.Arg59Cys Uncertain significance Single submitter
- CCDC9 p.Arg94Trp Uncertain significance Single submitter
- CCDC9 p.Asp145Asn Uncertain significance Single submitter
- CCDC9 p.Asp227Asn Uncertain significance Single submitter
- CCDC9 p.Asp251Asn Uncertain significance Single submitter
- CCDC9 p.Asp299Asn Uncertain significance Single submitter
- CCDC9 p.Asp426Asn Uncertain significance Single submitter
- CCDC9 p.Asp430Asn Uncertain significance Single submitter
- CCDC9 p.Glu118Lys Uncertain significance Single submitter
- CCDC9 p.Glu11Lys Uncertain significance Single submitter
- CCDC9 p.Glu165Lys Uncertain significance Single submitter
- CCDC9 p.Glu22Lys Uncertain significance Single submitter
- CCDC9 p.Glu236Lys Uncertain significance Single submitter
- CCDC9 p.Glu296Lys Uncertain significance Single submitter
- CCDC9 p.Glu417Lys Uncertain significance Single submitter
- CCDC9 p.Glu422Lys Uncertain significance Single submitter
- CCDC9 p.Glu434Asp Uncertain significance Single submitter
- CCDC9 p.Glu439Gln Uncertain significance Single submitter
- CCDC9 p.His515Tyr Uncertain significance Single submitter
- CCDC9 p.Lys19Glu Uncertain significance Single submitter
- CCDC9 p.Pro358His Uncertain significance Single submitter
- CCDC9 p.Pro489Thr Uncertain significance Single submitter
- CCDC9 p.Pro522Leu Uncertain significance Single submitter
- CCDC9 p.Pro522Thr Uncertain significance Single submitter
- CCDC9 p.Pro84Leu Uncertain significance Single submitter
- CCDC9 p.Pro96Leu Uncertain significance Single submitter
- CCDC9 p.Ser111Cys Uncertain significance Single submitter
- CCDC9 p.Ser487Phe Uncertain significance Single submitter
- CCDC9 p.Thr253Met Uncertain significance Single submitter
- CCDC9 p.Thr385Asn Uncertain significance Single submitter
- CCDC9 p.Val191Ala Uncertain significance Single submitter
- CCDC9 p.Val499Met Uncertain significance Single submitter
- CCDC9 p.Val50Ile Uncertain significance Single submitter
- CCDC9 p.Val66Met Likely benign Single submitter
All CCDC9 variants
Likely benign 4
- p.Ala309Val Single submitter
- p.Arg407Gln Single submitter
- p.Glu412= Single submitter
- p.Val66Met Single submitter ⚠
Uncertain significance 123
- p.Ala15Val Single submitter ⚠
- p.Ala175Thr Single submitter ⚠
- p.Ala322Val Single submitter ⚠
- p.Ala356Ser Single submitter ⚠
- p.Ala360Val Single submitter ⚠
- p.Ala405Val Single submitter ⚠
- p.Ala455Val Single submitter ⚠
- p.Ala525Ser Single submitter ⚠
- p.Arg102Gln Single submitter ⚠
- p.Arg102Trp Single submitter ⚠
- p.Arg110His Single submitter ⚠
- p.Arg121Gln Single submitter ⚠
- p.Arg128Cys Single submitter ⚠
- p.Arg130Trp Single submitter ⚠
- p.Arg133Trp Single submitter ⚠
- p.Arg135Gln Single submitter ⚠
- p.Arg151Cys Single submitter ⚠
- p.Arg151His Single submitter ⚠
- p.Arg160His Single submitter ⚠
- p.Arg192Trp Single submitter ⚠
- p.Arg200Gln Single submitter ⚠
- p.Arg201His Single submitter ⚠
- p.Arg210Trp Single submitter ⚠
- p.Arg213Trp Single submitter ⚠
- p.Arg217Cys Single submitter ⚠
- p.Arg217His Single submitter ⚠
- p.Arg218Trp Single submitter ⚠
- p.Arg232Cys Single submitter ⚠
- p.Arg242His Single submitter ⚠
- p.Arg243Gln Single submitter ⚠
- p.Arg259Trp Single submitter ⚠
- p.Arg261Leu Single submitter ⚠
- p.Arg281Gly Single submitter ⚠
- p.Arg315Cys Single submitter ⚠
- p.Arg33Gln Single submitter ⚠
- p.Arg344Cys Single submitter ⚠
- p.Arg344Ser Single submitter ⚠
- p.Arg346Met Single submitter ⚠
- p.Arg351Trp Single submitter ⚠
- p.Arg359Gly Single submitter ⚠
- p.Arg367Cys Single submitter ⚠
- p.Arg407Trp Single submitter ⚠
- p.Arg512Gln Single submitter ⚠
- p.Arg512Trp Single submitter ⚠
- p.Arg56Gln Single submitter ⚠
- p.Arg59Cys Single submitter ⚠
- p.Arg94Trp Single submitter ⚠
- p.Asn509Ser Single submitter ⚠
- p.Asn73Lys Single submitter ⚠
- p.Asp145Asn Single submitter ⚠
- p.Asp145Gly Single submitter ⚠
- p.Asp227Asn Single submitter ⚠
- p.Asp251Asn Single submitter ⚠
- p.Asp299Asn Single submitter ⚠
- p.Asp426Asn Single submitter ⚠
- p.Asp430Asn Single submitter ⚠
- p.Asp430Gly Single submitter ⚠
- p.Cys462Tyr Single submitter ⚠
- p.Gln353Arg Single submitter ⚠
- p.Gln98Arg Single submitter ⚠
- p.Glu118Lys Single submitter ⚠
- p.Glu11Lys Single submitter ⚠
- p.Glu165Lys Single submitter ⚠
- p.Glu22Lys Single submitter ⚠
- p.Glu236Lys Single submitter ⚠
- p.Glu296Lys Single submitter ⚠
- p.Glu372Asp Single submitter ⚠
- p.Glu388Gln Single submitter ⚠
- p.Glu417Lys Single submitter ⚠
- p.Glu422Lys Single submitter ⚠
- p.Glu434Asp Single submitter ⚠
- p.Glu439Gln Single submitter ⚠
- p.Gly203Arg Single submitter ⚠
- p.Gly220Ser Single submitter ⚠
- p.Gly418Glu Single submitter ⚠
- p.Gly441Ser Single submitter ⚠
- p.Gly92Arg Single submitter ⚠
- p.Gly93Ser Single submitter ⚠
- p.His310Arg Single submitter ⚠
- p.His364Arg Single submitter ⚠
- p.His515Tyr Single submitter ⚠
- p.Ile148Val Single submitter ⚠
- p.Ile427Leu Single submitter ⚠
- p.Leu140Phe Single submitter ⚠
- p.Leu235Phe Single submitter ⚠
- p.Lys19Glu Single submitter ⚠
- p.Lys303Gln Single submitter ⚠
- p.Lys392Arg Single submitter ⚠
- p.Met105Ile Single submitter ⚠
- p.Met105Val Single submitter ⚠
- p.Met252Val Single submitter ⚠
- p.Pro138Ser Single submitter ⚠
- p.Pro204Ser Single submitter ⚠
- p.Pro226Leu Single submitter ⚠
- p.Pro325Ser Single submitter ⚠
- p.Pro358His Single submitter ⚠
- p.Pro377Ser Single submitter ⚠
- p.Pro399Arg Single submitter ⚠
- p.Pro404Ser Single submitter ⚠
- p.Pro453Ser Single submitter ⚠
- p.Pro457Leu Single submitter ⚠
- p.Pro470Leu Single submitter ⚠
- p.Pro470Ser Single submitter ⚠
- p.Pro473Gln Single submitter ⚠
- p.Pro480Ser Single submitter ⚠
- p.Pro489Thr Single submitter ⚠
- p.Pro522Leu Single submitter ⚠
- p.Pro522Thr Single submitter ⚠
- p.Pro84Leu Single submitter ⚠
- p.Pro96Leu Single submitter ⚠
- p.Ser111Cys Single submitter ⚠
- p.Ser208Thr Single submitter ⚠
- p.Ser349Asn Single submitter ⚠
- p.Ser487Phe Single submitter ⚠
- p.Thr253Met Single submitter ⚠
- p.Thr329Ala Single submitter ⚠
- p.Thr385Asn Single submitter ⚠
- p.Thr83Pro Single submitter ⚠
- p.Val185Phe Single submitter ⚠
- p.Val191Ala Single submitter ⚠
- p.Val499Met Single submitter ⚠
- p.Val50Ile Single submitter ⚠
- p.Val66Leu Single submitter ⚠