CCDC90B — 45 ClinVar variants
All ClinVar germline CCDC90B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
45 Uncertain significance
Full CCDC90B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC90B p.Ala6Thr Uncertain significance Single submitter
- CCDC90B p.Arg138Lys Uncertain significance Single submitter
- CCDC90B p.Arg161Gln Uncertain significance Single submitter
- CCDC90B p.Arg163Thr Uncertain significance Single submitter
- CCDC90B p.Arg233Ser Uncertain significance Single submitter
- CCDC90B p.Arg47Trp Uncertain significance Single submitter
- CCDC90B p.Arg4Pro Uncertain significance Single submitter
- CCDC90B p.Asn2Ser Uncertain significance Single submitter
- CCDC90B p.Asp125Ala Uncertain significance Single submitter
- CCDC90B p.Gln68Glu Uncertain significance Single submitter
- CCDC90B p.Gln79Arg Uncertain significance Single submitter
- CCDC90B p.Glu101Lys Uncertain significance Single submitter
- CCDC90B p.Glu194Lys Uncertain significance Single submitter
- CCDC90B p.Glu194Val Uncertain significance Single submitter
- CCDC90B p.Gly43Glu Uncertain significance Single submitter
- CCDC90B p.His157Arg Uncertain significance Single submitter
- CCDC90B p.His64Arg Uncertain significance Single submitter
- CCDC90B p.His73Leu Uncertain significance Single submitter
- CCDC90B p.Ile128Thr Uncertain significance Single submitter
- CCDC90B p.Leu11Pro Uncertain significance Single submitter
- CCDC90B p.Leu235Pro Uncertain significance Single submitter
- CCDC90B p.Leu87Ser Uncertain significance Single submitter
- CCDC90B p.Leu90Val Uncertain significance Single submitter
- CCDC90B p.Lys186Arg Uncertain significance Single submitter
- CCDC90B p.Lys228Arg Uncertain significance Single submitter
- CCDC90B p.Met189Thr Uncertain significance Single submitter
- CCDC90B p.Pro23Thr Uncertain significance Single submitter
- CCDC90B p.Ser12Cys Uncertain significance Single submitter
- CCDC90B p.Ser132Arg Uncertain significance Single submitter
- CCDC90B p.Ser28Pro Uncertain significance Single submitter
- CCDC90B p.Thr37Ile Uncertain significance Single submitter
- CCDC90B p.Thr39Ala Uncertain significance Single submitter
- CCDC90B p.Thr39Lys Uncertain significance Single submitter
- CCDC90B p.Thr40Ala Uncertain significance Single submitter
- CCDC90B p.Thr72Ile Uncertain significance Single submitter
- CCDC90B p.Val177Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CCDC90B p.Ala6Asp Uncertain significance Single submitter
- CCDC90B p.Arg161Gly Uncertain significance Single submitter
- CCDC90B p.Arg8Trp Uncertain significance Single submitter
- CCDC90B p.Asp125Glu Uncertain significance Single submitter
- CCDC90B p.Thr231Ile Uncertain significance Single submitter
- CCDC90B p.Val84Leu Uncertain significance Single submitter
All CCDC90B variants
Uncertain significance 45
- p.Ala6Asp Single submitter ⚠
- p.Ala6Thr Single submitter ⚠
- p.Arg138Lys Single submitter ⚠
- p.Arg161Gln Single submitter ⚠
- p.Arg161Gly Single submitter ⚠
- p.Arg163Thr Single submitter ⚠
- p.Arg233Cys Single submitter
- p.Arg233Ser Single submitter ⚠
- p.Arg47Trp Single submitter ⚠
- p.Arg4Pro Single submitter ⚠
- p.Arg8Trp Single submitter ⚠
- p.Asn2Ser Single submitter ⚠
- p.Asp125Ala Single submitter ⚠
- p.Asp125Glu Single submitter ⚠
- p.Gln68Glu Single submitter ⚠
- p.Gln79Arg Single submitter ⚠
- p.Glu101Lys Single submitter ⚠
- p.Glu194Lys Single submitter ⚠
- p.Glu194Val Single submitter ⚠
- p.Gly43Glu Single submitter ⚠
- p.His118Arg Single submitter
- p.His157Arg Single submitter ⚠
- p.His64Arg Single submitter ⚠
- p.His73Leu Single submitter ⚠
- p.Ile128Thr Single submitter ⚠
- p.Leu11Pro Single submitter ⚠
- p.Leu235Pro Single submitter ⚠
- p.Leu87Ser Single submitter ⚠
- p.Leu90Val Single submitter ⚠
- p.Lys186Arg Single submitter ⚠
- p.Lys228Arg Single submitter ⚠
- p.Met189Thr Single submitter ⚠
- p.Pro23Thr Single submitter ⚠
- p.Ser12Cys Single submitter ⚠
- p.Ser132Arg Single submitter ⚠
- p.Ser28Pro Single submitter ⚠
- p.Thr222Ser Single submitter
- p.Thr231Ile Single submitter ⚠
- p.Thr37Ile Single submitter ⚠
- p.Thr39Ala Single submitter ⚠
- p.Thr39Lys Single submitter ⚠
- p.Thr40Ala Single submitter ⚠
- p.Thr72Ile Single submitter ⚠
- p.Val177Ile Single submitter ⚠
- p.Val84Leu Single submitter ⚠