CCDC91 — 56 ClinVar variants
All ClinVar germline CCDC91 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
2 Benign · 3 Likely benign · 51 Uncertain significance
Full CCDC91 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC91 p.Ala127Thr Uncertain significance Single submitter
- CCDC91 p.Ala181Thr Uncertain significance Single submitter
- CCDC91 p.Ala209Thr Uncertain significance Single submitter
- CCDC91 p.Ala219Thr Uncertain significance Single submitter
- CCDC91 p.Ala28Ser Uncertain significance Single submitter
- CCDC91 p.Ala36Glu Uncertain significance Single submitter
- CCDC91 p.Arg411Cys Uncertain significance Single submitter
- CCDC91 p.Asn113Asp Uncertain significance Single submitter
- CCDC91 p.Asp65Val Uncertain significance Single submitter
- CCDC91 p.Asp99Gly Uncertain significance Single submitter
- CCDC91 p.Gln153Arg Uncertain significance Single submitter
- CCDC91 p.Gln92Arg Uncertain significance Single submitter
- CCDC91 p.Gly126Glu Uncertain significance Single submitter
- CCDC91 p.Gly172Ala Uncertain significance Single submitter
- CCDC91 p.Gly172Ser Uncertain significance Single submitter
- CCDC91 p.His41Pro Uncertain significance Single submitter
- CCDC91 p.Ile237Val Uncertain significance Single submitter
- CCDC91 p.Ile240Thr Uncertain significance Single submitter
- CCDC91 p.Ile400Met Uncertain significance Single submitter
- CCDC91 p.Ile433Thr Uncertain significance Single submitter
- CCDC91 p.Ile49Thr Uncertain significance Single submitter
- CCDC91 p.Lys171Glu Uncertain significance Single submitter
- CCDC91 p.Lys383Glu Uncertain significance Single submitter
- CCDC91 p.Thr264Lys Uncertain significance Single submitter
- CCDC91 p.Thr435Met Uncertain significance Single submitter
- CCDC91 p.Val129Ala Uncertain significance Single submitter
- CCDC91 p.Val159Ala Uncertain significance Single submitter
- CCDC91 p.Val351Leu Uncertain significance Single submitter
- CCDC91 p.Val40Ile Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CCDC91 p.Gln403Lys Benign Multiple submitters
- CCDC91 p.Ala334Gly Uncertain significance Single submitter
- CCDC91 p.Arg257Ser Uncertain significance Single submitter
- CCDC91 p.Arg380Gln Uncertain significance Single submitter
- CCDC91 p.Arg393Thr Uncertain significance Single submitter
- CCDC91 p.Asp215Tyr Uncertain significance Single submitter
- CCDC91 p.Asp394Val Uncertain significance Single submitter
- CCDC91 p.Cys247Phe Uncertain significance Single submitter
- CCDC91 p.Glu170Asp Uncertain significance Single submitter
- CCDC91 p.Glu249Gln Uncertain significance Single submitter
- CCDC91 p.Glu295Val Uncertain significance Single submitter
- CCDC91 p.Glu325Lys Uncertain significance Single submitter
- CCDC91 p.Glu330Gly Uncertain significance Single submitter
- CCDC91 p.Glu361Lys Uncertain significance Single submitter
- CCDC91 p.His195Tyr Uncertain significance Single submitter
- CCDC91 p.Leu250Ser Uncertain significance Single submitter
- CCDC91 p.Leu292Trp Uncertain significance Single submitter
- CCDC91 p.Lys194Gln Uncertain significance Single submitter
- CCDC91 p.Lys346Glu Uncertain significance Single submitter
- CCDC91 p.Lys383Asn Uncertain significance Single submitter
- CCDC91 p.Ser140Gly Uncertain significance Single submitter
- CCDC91 p.Thr96Ile Uncertain significance Single submitter
- CCDC91 p.Tyr236Ser Uncertain significance Single submitter
All CCDC91 variants
Benign 2
- p.Asp121Gly Multiple submitters
- p.Gln403Lys Multiple submitters ⚠
Likely benign 3
- p.Arg53His Single submitter
- p.Ile400Val Single submitter
- p.Val322Ile Single submitter
Uncertain significance 51
- p.Ala127Thr Single submitter ⚠
- p.Ala181Thr Single submitter ⚠
- p.Ala209Thr Single submitter ⚠
- p.Ala219Thr Single submitter ⚠
- p.Ala28Ser Single submitter ⚠
- p.Ala334Gly Single submitter ⚠
- p.Ala36Glu Single submitter ⚠
- p.Arg257Ser Single submitter ⚠
- p.Arg380Gln Single submitter ⚠
- p.Arg393Thr Single submitter ⚠
- p.Arg411Cys Single submitter ⚠
- p.Asn113Asp Single submitter ⚠
- p.Asp215Tyr Single submitter ⚠
- p.Asp394Val Single submitter ⚠
- p.Asp65Val Single submitter ⚠
- p.Asp99Gly Single submitter ⚠
- p.Cys247Phe Single submitter ⚠
- p.Gln153Arg Single submitter ⚠
- p.Gln92Arg Single submitter ⚠
- p.Glu170Asp Single submitter ⚠
- p.Glu249Gln Single submitter ⚠
- p.Glu295Val Single submitter ⚠
- p.Glu325Lys Single submitter ⚠
- p.Glu330Gly Single submitter ⚠
- p.Glu361Lys Single submitter ⚠
- p.Gly126Glu Single submitter ⚠
- p.Gly172Ala Single submitter ⚠
- p.Gly172Ser Single submitter ⚠
- p.His195Tyr Single submitter ⚠
- p.His41Pro Single submitter ⚠
- p.Ile237Val Single submitter ⚠
- p.Ile240Thr Single submitter ⚠
- p.Ile400Met Single submitter ⚠
- p.Ile433Thr Single submitter ⚠
- p.Ile49Thr Single submitter ⚠
- p.Leu250Ser Single submitter ⚠
- p.Leu292Trp Single submitter ⚠
- p.Lys171Glu Single submitter ⚠
- p.Lys194Gln Single submitter ⚠
- p.Lys346Glu Single submitter ⚠
- p.Lys383Asn Single submitter ⚠
- p.Lys383Glu Single submitter ⚠
- p.Ser140Gly Single submitter ⚠
- p.Thr264Lys Single submitter ⚠
- p.Thr435Met Single submitter ⚠
- p.Thr96Ile Single submitter ⚠
- p.Tyr236Ser Single submitter ⚠
- p.Val129Ala Single submitter ⚠
- p.Val159Ala Single submitter ⚠
- p.Val351Leu Single submitter ⚠
- p.Val40Ile Single submitter ⚠