CCDC92 — 63 ClinVar variants
All ClinVar germline CCDC92 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
1 Likely benign · 62 Uncertain significance
Full CCDC92 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC92 p.Ala114Thr Uncertain significance Single submitter
- CCDC92 p.Ala178Asp Uncertain significance Single submitter
- CCDC92 p.Ala226Val Uncertain significance Single submitter
- CCDC92 p.Ala269Thr Uncertain significance Single submitter
- CCDC92 p.Arg223Gly Uncertain significance Single submitter
- CCDC92 p.Arg234Gln Uncertain significance Single submitter
- CCDC92 p.Arg294Gln Uncertain significance Single submitter
- CCDC92 p.Arg39Gln Uncertain significance Single submitter
- CCDC92 p.Asp10Asn Uncertain significance Single submitter
- CCDC92 p.Asp271Asn Uncertain significance Single submitter
- CCDC92 p.Asp313Asn Uncertain significance Single submitter
- CCDC92 p.Asp328Glu Uncertain significance Single submitter
- CCDC92 p.Gln73Glu Uncertain significance Single submitter
- CCDC92 p.Glu101Gln Uncertain significance Single submitter
- CCDC92 p.Glu101Lys Uncertain significance Single submitter
- CCDC92 p.Glu254Lys Uncertain significance Single submitter
- CCDC92 p.Glu282Lys Uncertain significance Single submitter
- CCDC92 p.Glu306Lys Uncertain significance Single submitter
- CCDC92 p.Glu51Lys Uncertain significance Single submitter
- CCDC92 p.Glu72Gly Uncertain significance Single submitter
- CCDC92 p.Gly290Ala Uncertain significance Single submitter
- CCDC92 p.Gly317Arg Uncertain significance Single submitter
- CCDC92 p.Gly77Arg Uncertain significance Single submitter
- CCDC92 p.His277Gln Uncertain significance Single submitter
- CCDC92 p.His285Arg Uncertain significance Single submitter
- CCDC92 p.His288Gln Uncertain significance Single submitter
- CCDC92 p.Leu34Phe Uncertain significance Single submitter
- CCDC92 p.Leu35Pro Uncertain significance Single submitter
- CCDC92 p.Lys168Gln Uncertain significance Single submitter
- CCDC92 p.Lys69Arg Uncertain significance Single submitter
- CCDC92 p.Pro13Ser Uncertain significance Single submitter
- CCDC92 p.Pro193Leu Uncertain significance Single submitter
- CCDC92 p.Pro262Leu Uncertain significance Single submitter
- CCDC92 p.Pro267Ala Uncertain significance Single submitter
- CCDC92 p.Pro279Leu Uncertain significance Single submitter
- CCDC92 p.Ser228Gly Uncertain significance Single submitter
- CCDC92 p.Ser29Asn Uncertain significance Single submitter
- CCDC92 p.Ser7Leu Uncertain significance Single submitter
- CCDC92 p.Thr299Ile Uncertain significance Single submitter
- CCDC92 p.Thr327Ala Uncertain significance Single submitter
- CCDC92 p.Val221Phe Uncertain significance Single submitter
- CCDC92 p.Val264Ile Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- CCDC92 p.Ala93Val Uncertain significance Single submitter
- CCDC92 p.Arg203His Uncertain significance Single submitter
- CCDC92 p.Arg250Thr Uncertain significance Single submitter
- CCDC92 p.Arg294Trp Uncertain significance Single submitter
- CCDC92 p.Arg54Trp Uncertain significance Single submitter
- CCDC92 p.Glu125Lys Uncertain significance Single submitter
- CCDC92 p.Glu127Asp Uncertain significance Single submitter
- CCDC92 p.Glu127Gln Uncertain significance Single submitter
- CCDC92 p.Glu24Asp Uncertain significance Single submitter
- CCDC92 p.Gly225Arg Uncertain significance Single submitter
- CCDC92 p.Gly290Arg Uncertain significance Single submitter
- CCDC92 p.Lys112Thr Uncertain significance Single submitter
- CCDC92 p.Lys128Met Uncertain significance Single submitter
- CCDC92 p.Lys32Asn Uncertain significance Single submitter
- CCDC92 p.Lys46Asn Uncertain significance Single submitter
- CCDC92 p.Lys85Asn Uncertain significance Single submitter
- CCDC92 p.Met206Val Uncertain significance Single submitter
- CCDC92 p.Pro267Arg Uncertain significance Single submitter
- CCDC92 p.Ser153Arg Uncertain significance Single submitter
- CCDC92 p.Thr201Met Uncertain significance Single submitter
All CCDC92 variants
Likely benign 1
- p.Gly274Ser Single submitter
Uncertain significance 62
- p.Ala114Thr Single submitter ⚠
- p.Ala178Asp Single submitter ⚠
- p.Ala226Val Single submitter ⚠
- p.Ala269Thr Single submitter ⚠
- p.Ala93Val Single submitter ⚠
- p.Arg203His Single submitter ⚠
- p.Arg223Gly Single submitter ⚠
- p.Arg234Gln Single submitter ⚠
- p.Arg250Thr Single submitter ⚠
- p.Arg294Gln Single submitter ⚠
- p.Arg294Trp Single submitter ⚠
- p.Arg39Gln Single submitter ⚠
- p.Arg54Trp Single submitter ⚠
- p.Asp10Asn Single submitter ⚠
- p.Asp271Asn Single submitter ⚠
- p.Asp313Asn Single submitter ⚠
- p.Asp328Glu Single submitter ⚠
- p.Gln73Glu Single submitter ⚠
- p.Glu101Gln Single submitter ⚠
- p.Glu101Lys Single submitter ⚠
- p.Glu125Lys Single submitter ⚠
- p.Glu127Asp Single submitter ⚠
- p.Glu127Gln Single submitter ⚠
- p.Glu24Asp Single submitter ⚠
- p.Glu254Lys Single submitter ⚠
- p.Glu282Lys Single submitter ⚠
- p.Glu306Lys Single submitter ⚠
- p.Glu51Lys Single submitter ⚠
- p.Glu72Gly Single submitter ⚠
- p.Gly225Arg Single submitter ⚠
- p.Gly290Ala Single submitter ⚠
- p.Gly290Arg Single submitter ⚠
- p.Gly317Arg Single submitter ⚠
- p.Gly77Arg Single submitter ⚠
- p.His277Gln Single submitter ⚠
- p.His285Arg Single submitter ⚠
- p.His288Gln Single submitter ⚠
- p.Leu34Phe Single submitter ⚠
- p.Leu35Pro Single submitter ⚠
- p.Lys112Thr Single submitter ⚠
- p.Lys128Met Single submitter ⚠
- p.Lys168Gln Single submitter ⚠
- p.Lys32Asn Single submitter ⚠
- p.Lys46Asn Single submitter ⚠
- p.Lys69Arg Single submitter ⚠
- p.Lys85Asn Single submitter ⚠
- p.Met206Val Single submitter ⚠
- p.Pro13Ser Single submitter ⚠
- p.Pro193Leu Single submitter ⚠
- p.Pro262Leu Single submitter ⚠
- p.Pro267Ala Single submitter ⚠
- p.Pro267Arg Single submitter ⚠
- p.Pro279Leu Single submitter ⚠
- p.Ser153Arg Single submitter ⚠
- p.Ser228Gly Single submitter ⚠
- p.Ser29Asn Single submitter ⚠
- p.Ser7Leu Single submitter ⚠
- p.Thr201Met Single submitter ⚠
- p.Thr299Ile Single submitter ⚠
- p.Thr327Ala Single submitter ⚠
- p.Val221Phe Single submitter ⚠
- p.Val264Ile Single submitter ⚠