CCDC97 — 69 ClinVar variants
All ClinVar germline CCDC97 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
1 Likely benign · 68 Uncertain significance
Full CCDC97 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCDC97 p.Ala121Pro Uncertain significance Single submitter
- CCDC97 p.Ala132Val Uncertain significance Single submitter
- CCDC97 p.Ala246Ser Uncertain significance Single submitter
- CCDC97 p.Arg112His Uncertain significance Single submitter
- CCDC97 p.Arg148His Uncertain significance Single submitter
- CCDC97 p.Arg151Leu Uncertain significance Single submitter
- CCDC97 p.Arg153Cys Uncertain significance Single submitter
- CCDC97 p.Arg153His Uncertain significance Single submitter
- CCDC97 p.Arg180Trp Uncertain significance Single submitter
- CCDC97 p.Arg288Cys Uncertain significance Single submitter
- CCDC97 p.Arg74His Uncertain significance Single submitter
- CCDC97 p.Asp256Gly Uncertain significance Single submitter
- CCDC97 p.Asp274Asn Uncertain significance Single submitter
- CCDC97 p.Asp308Asn Uncertain significance Single submitter
- CCDC97 p.Asp311Asn Uncertain significance Single submitter
- CCDC97 p.Asp313Asn Uncertain significance Single submitter
- CCDC97 p.Asp334Glu Uncertain significance Single submitter
- CCDC97 p.Asp334Gly Uncertain significance Single submitter
- CCDC97 p.Gln226His Uncertain significance Single submitter
- CCDC97 p.Glu102Lys Uncertain significance Single submitter
- CCDC97 p.Glu164Lys Uncertain significance Single submitter
- CCDC97 p.Glu277Lys Uncertain significance Single submitter
- CCDC97 p.Gly57Arg Uncertain significance Single submitter
- CCDC97 p.His24Arg Uncertain significance Single submitter
- CCDC97 p.Leu87Ser Uncertain significance Single submitter
- CCDC97 p.Lys209Arg Uncertain significance Single submitter
- CCDC97 p.Phe123Tyr Uncertain significance Single submitter
- CCDC97 p.Pro182Ser Uncertain significance Single submitter
- CCDC97 p.Pro219Ser Uncertain significance Single submitter
- CCDC97 p.Pro273Ser Uncertain significance Single submitter
- CCDC97 p.Pro338Thr Uncertain significance Single submitter
- CCDC97 p.Thr286Ile Uncertain significance Single submitter
- CCDC97 p.Trp271Cys Uncertain significance Single submitter
- CCDC97 p.Tyr303Cys Uncertain significance Single submitter
- CCDC97 p.Val41Leu Uncertain significance Single submitter
- CCDC97 p.Val63Leu Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- CCDC97 p.Arg110Cys Uncertain significance Single submitter
- CCDC97 p.Arg110His Uncertain significance Single submitter
- CCDC97 p.Arg112Cys Uncertain significance Single submitter
- CCDC97 p.Arg116His Uncertain significance Single submitter
- CCDC97 p.Arg116Leu Uncertain significance Single submitter
- CCDC97 p.Arg127His Uncertain significance Single submitter
- CCDC97 p.Arg131His Uncertain significance Single submitter
- CCDC97 p.Arg131Ser Uncertain significance Single submitter
- CCDC97 p.Arg146Trp Uncertain significance Single submitter
- CCDC97 p.Arg155Cys Uncertain significance Single submitter
- CCDC97 p.Arg157Gln Uncertain significance Single submitter
- CCDC97 p.Arg157Trp Uncertain significance Single submitter
- CCDC97 p.Arg178Gln Uncertain significance Single submitter
- CCDC97 p.Arg236Cys Uncertain significance Single submitter
- CCDC97 p.Arg292Cys Uncertain significance Single submitter
- CCDC97 p.Arg292His Uncertain significance Single submitter
- CCDC97 p.Asn309Asp Uncertain significance Single submitter
- CCDC97 p.Gln240Arg Uncertain significance Single submitter
- CCDC97 p.Glu170Lys Uncertain significance Single submitter
- CCDC97 p.Glu175Lys Uncertain significance Single submitter
- CCDC97 p.Glu229Lys Uncertain significance Single submitter
- CCDC97 p.Glu243Lys Uncertain significance Single submitter
- CCDC97 p.Glu255Gly Uncertain significance Single submitter
- CCDC97 p.Gly214Arg Uncertain significance Single submitter
- CCDC97 p.Leu150Pro Uncertain significance Single submitter
- CCDC97 p.Leu238Phe Uncertain significance Single submitter
- CCDC97 p.Pro207His Uncertain significance Single submitter
- CCDC97 p.Ser212Phe Uncertain significance Single submitter
- CCDC97 p.Thr144Ile Uncertain significance Single submitter
- CCDC97 p.Thr152Asn Uncertain significance Single submitter
- CCDC97 p.Val126Met Uncertain significance Single submitter
- CCDC97 p.Val318Met Uncertain significance Single submitter
All CCDC97 variants
Likely benign 1
- p.Arg141Gln Single submitter
Uncertain significance 68
- p.Ala121Pro Single submitter ⚠
- p.Ala132Val Single submitter ⚠
- p.Ala246Ser Single submitter ⚠
- p.Arg110Cys Single submitter ⚠
- p.Arg110His Single submitter ⚠
- p.Arg112Cys Single submitter ⚠
- p.Arg112His Single submitter ⚠
- p.Arg116His Single submitter ⚠
- p.Arg116Leu Single submitter ⚠
- p.Arg127His Single submitter ⚠
- p.Arg131His Single submitter ⚠
- p.Arg131Ser Single submitter ⚠
- p.Arg146Trp Single submitter ⚠
- p.Arg148His Single submitter ⚠
- p.Arg151Leu Single submitter ⚠
- p.Arg153Cys Single submitter ⚠
- p.Arg153His Single submitter ⚠
- p.Arg155Cys Single submitter ⚠
- p.Arg157Gln Single submitter ⚠
- p.Arg157Trp Single submitter ⚠
- p.Arg178Gln Single submitter ⚠
- p.Arg180Trp Single submitter ⚠
- p.Arg236Cys Single submitter ⚠
- p.Arg288Cys Single submitter ⚠
- p.Arg292Cys Single submitter ⚠
- p.Arg292His Single submitter ⚠
- p.Arg74His Single submitter ⚠
- p.Asn309Asp Single submitter ⚠
- p.Asp256Gly Single submitter ⚠
- p.Asp274Asn Single submitter ⚠
- p.Asp308Asn Single submitter ⚠
- p.Asp311Asn Single submitter ⚠
- p.Asp313Asn Single submitter ⚠
- p.Asp334Glu Single submitter ⚠
- p.Asp334Gly Single submitter ⚠
- p.Gln226His Single submitter ⚠
- p.Gln240Arg Single submitter ⚠
- p.Glu102Lys Single submitter ⚠
- p.Glu164Lys Single submitter ⚠
- p.Glu170Lys Single submitter ⚠
- p.Glu175Lys Single submitter ⚠
- p.Glu229Lys Single submitter ⚠
- p.Glu243Lys Single submitter ⚠
- p.Glu255Gly Single submitter ⚠
- p.Glu277Lys Single submitter ⚠
- p.Gly214Arg Single submitter ⚠
- p.Gly57Arg Single submitter ⚠
- p.His24Arg Single submitter ⚠
- p.Leu150Pro Single submitter ⚠
- p.Leu238Phe Single submitter ⚠
- p.Leu87Ser Single submitter ⚠
- p.Lys209Arg Single submitter ⚠
- p.Phe123Tyr Single submitter ⚠
- p.Pro182Ser Single submitter ⚠
- p.Pro207His Single submitter ⚠
- p.Pro219Ser Single submitter ⚠
- p.Pro273Ser Single submitter ⚠
- p.Pro338Thr Single submitter ⚠
- p.Ser212Phe Single submitter ⚠
- p.Thr144Ile Single submitter ⚠
- p.Thr152Asn Single submitter ⚠
- p.Thr286Ile Single submitter ⚠
- p.Trp271Cys Single submitter ⚠
- p.Tyr303Cys Single submitter ⚠
- p.Val126Met Single submitter ⚠
- p.Val318Met Single submitter ⚠
- p.Val41Leu Single submitter ⚠
- p.Val63Leu Single submitter ⚠