CCL13 — 12 ClinVar variants
All ClinVar germline CCL13 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
1 Likely benign · 11 Uncertain significance
Full CCL13 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCL13 p.Asn84Ser Uncertain significance Single submitter
- CCL13 p.Asp26Gly Uncertain significance Single submitter
- CCL13 p.Cys35Phe Uncertain significance Single submitter
- CCL13 p.Gln46Arg Uncertain significance Single submitter
- CCL13 p.Thr14Ile Uncertain significance Single submitter
- CCL13 p.Thr55Asn Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All CCL13 variants
Likely benign 1
- p.Met13Ile Single submitter
Uncertain significance 11
- p.Arg91Trp Single submitter ⚠
- p.Asn84Ser Single submitter ⚠
- p.Asp26Gly Single submitter ⚠
- p.Cys35Phe Single submitter ⚠
- p.Gln46Arg Single submitter ⚠
- p.Leu7Phe Single submitter ⚠
- p.Lys2Glu Single submitter ⚠
- p.Lys80Met Single submitter ⚠
- p.Thr14Ile Single submitter ⚠
- p.Thr54Ala Single submitter ⚠
- p.Thr55Asn Single submitter ⚠