CCL14 — 14 ClinVar variants
All ClinVar germline CCL14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
2 Likely benign · 12 Uncertain significance
Full CCL14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 7
The independent predictors disagree with each other — read with care.
- CCL14 p.Gly63Arg Uncertain significance Single submitter
- CCL14 p.Ile64Thr Uncertain significance Single submitter
- CCL14 p.Leu13Phe Uncertain significance Single submitter
- CCL14 p.Leu13Pro Uncertain significance Single submitter
- CCL14 p.Phe37Leu Likely benign Single submitter
- CCL14 p.Ser60Pro Uncertain significance Single submitter
- CCL14 p.Val5Met Likely benign Single submitter
All CCL14 variants
Likely benign 2
- p.Phe37Leu Single submitter ⚠
- p.Val5Met Single submitter ⚠
Uncertain significance 12
- c.79+788A>G Single submitter
- c.79+790C>A Single submitter
- c.79+820G>A Single submitter
- p.Cys59Ser Single submitter ⚠
- p.Cys59Tyr Single submitter ⚠
- p.Gln58Lys Single submitter ⚠
- p.Gly28Glu Single submitter ⚠
- p.Gly63Arg Single submitter ⚠
- p.Ile64Thr Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Leu13Pro Single submitter ⚠
- p.Ser60Pro Single submitter ⚠