CCL16 — 22 ClinVar variants
All ClinVar germline CCL16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
6 Likely benign · 16 Uncertain significance
Full CCL16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCL16 p.Asp82Asn Uncertain significance Single submitter
- CCL16 p.Glu5Lys Uncertain significance Single submitter
- CCL16 p.Gly112Val Uncertain significance Single submitter
- CCL16 p.Leu13Phe Uncertain significance Single submitter
- CCL16 p.Leu95Met Uncertain significance Single submitter
- CCL16 p.Lys26Arg Uncertain significance Single submitter
- CCL16 p.Pro114Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CCL16 p.Ala64Thr Uncertain significance Single submitter
- CCL16 p.Asp82Gly Uncertain significance Single submitter
- CCL16 p.Asp90Asn Likely benign Single submitter
- CCL16 p.Glu74Ala Uncertain significance Single submitter
- CCL16 p.Gly53Glu Uncertain significance Single submitter
- CCL16 p.Leu62Pro Uncertain significance Single submitter
- CCL16 p.Leu93Pro Uncertain significance Single submitter
- CCL16 p.Lys70Met Uncertain significance Single submitter
- CCL16 p.Thr103Met Uncertain significance Single submitter
- CCL16 p.Val68Asp Uncertain significance Single submitter
All CCL16 variants
Likely benign 6
- p.Arg22His Single submitter
- p.Asn80Ser Single submitter
- p.Asp90Asn Single submitter ⚠
- p.Gly112Asp Single submitter
- p.Thr98Ser Single submitter
- p.Val68Ile Single submitter
Uncertain significance 16
- p.Ala64Thr Single submitter ⚠
- p.Asp82Asn Single submitter ⚠
- p.Asp82Gly Single submitter ⚠
- p.Glu5Lys Single submitter ⚠
- p.Glu74Ala Single submitter ⚠
- p.Gly112Val Single submitter ⚠
- p.Gly53Glu Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Leu62Pro Single submitter ⚠
- p.Leu93Pro Single submitter ⚠
- p.Leu95Met Single submitter ⚠
- p.Lys26Arg Single submitter ⚠
- p.Lys70Met Single submitter ⚠
- p.Pro114Leu Single submitter ⚠
- p.Thr103Met Single submitter ⚠
- p.Val68Asp Single submitter ⚠