CCL17 — 17 ClinVar variants
All ClinVar germline CCL17 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
1 Benign · 16 Uncertain significance
Full CCL17 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCL17 p.Ala41Thr Uncertain significance Single submitter
- CCL17 p.Ala41Val Uncertain significance Single submitter
- CCL17 p.Ala61Val Uncertain significance Single submitter
- CCL17 p.Arg25Gln Uncertain significance Single submitter
- CCL17 p.Arg31Gln Uncertain significance Single submitter
- CCL17 p.Asp56Gly Uncertain significance Single submitter
- CCL17 p.Cys33Arg Uncertain significance Single submitter
- CCL17 p.Gly26Val Uncertain significance Single submitter
- CCL17 p.Val10Phe Uncertain significance Single submitter
- CCL17 p.Val63Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CCL17 p.Ala16Thr Uncertain significance Single submitter
- CCL17 p.Arg59Thr Uncertain significance Single submitter
- CCL17 p.Gly40Glu Uncertain significance Single submitter
- CCL17 p.Gly69Ser Uncertain significance Single submitter
- CCL17 p.Ile42Met Uncertain significance Single submitter
- CCL17 p.Ser90Gly Uncertain significance Single submitter
All CCL17 variants
Benign 1
- p.Asn28= Multiple submitters
Uncertain significance 16
- p.Ala16Thr Single submitter ⚠
- p.Ala41Thr Single submitter ⚠
- p.Ala41Val Single submitter ⚠
- p.Ala61Val Single submitter ⚠
- p.Arg25Gln Single submitter ⚠
- p.Arg31Gln Single submitter ⚠
- p.Arg59Thr Single submitter ⚠
- p.Asp56Gly Single submitter ⚠
- p.Cys33Arg Single submitter ⚠
- p.Gly26Val Single submitter ⚠
- p.Gly40Glu Single submitter ⚠
- p.Gly69Ser Single submitter ⚠
- p.Ile42Met Single submitter ⚠
- p.Ser90Gly Single submitter ⚠
- p.Val10Phe Single submitter ⚠
- p.Val63Ile Single submitter ⚠