CCL18 — 12 ClinVar variants
All ClinVar germline CCL18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
2 Likely benign · 10 Uncertain significance
Full CCL18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 7
The independent predictors disagree with each other — read with care.
- CCL18 p.Ala5Glu Uncertain significance Single submitter
- CCL18 p.Ala5Thr Uncertain significance Single submitter
- CCL18 p.Arg65Thr Uncertain significance Single submitter
- CCL18 p.Asn74Asp Uncertain significance Single submitter
- CCL18 p.Gln53Pro Uncertain significance Single submitter
- CCL18 p.Ser51Arg Uncertain significance Single submitter
- CCL18 p.Tyr47His Uncertain significance Single submitter
All CCL18 variants
Likely benign 2
- p.Asp72Asn Single submitter
- p.Ile44Val Single submitter
Uncertain significance 10
- p.Ala5Glu Single submitter ⚠
- p.Ala5Thr Single submitter ⚠
- p.Arg65Thr Single submitter ⚠
- p.Arg67Gln Single submitter ⚠
- p.Asn74Asp Single submitter ⚠
- p.Asn74Lys Single submitter ⚠
- p.Gln53Pro Single submitter ⚠
- p.Ser51Arg Single submitter ⚠
- p.Ser83Arg Single submitter ⚠
- p.Tyr47His Single submitter ⚠