CCL20 — 11 ClinVar variants
All ClinVar germline CCL20 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 7 flagged for review →
1 Benign · 4 Likely benign · 6 Uncertain significance
Full CCL20 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 7
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 4
The independent predictors disagree with each other — read with care.
All CCL20 variants
Benign 1
- p.Cys74= Single submitter
Likely benign 4
- p.Arg39His Single submitter ⚠
- p.Arg51Gln Single submitter
- p.Arg87His Single submitter
- p.Ile63Val Single submitter
Uncertain significance 6
- p.Arg87Cys Single submitter ⚠
- p.Asn61Ser Single submitter ⚠
- p.Gly57Val Single submitter ⚠
- p.Ile64Val Single submitter ⚠
- p.Leu9Pro Single submitter ⚠
- p.Ser14Leu Single submitter ⚠