CCL21 — 17 ClinVar variants
All ClinVar germline CCL21 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
1 Benign · 2 Likely benign · 14 Uncertain significance
Full CCL21 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCL21 p.Ala42Ser Uncertain significance Single submitter
- CCL21 p.Ala72Glu Uncertain significance Single submitter
- CCL21 p.Arg49Gln Uncertain significance Single submitter
- CCL21 p.Arg67Leu Uncertain significance Single submitter
- CCL21 p.Gln129Glu Uncertain significance Single submitter
- CCL21 p.Gln3Arg Uncertain significance Single submitter
- CCL21 p.Glu126Lys Uncertain significance Single submitter
- CCL21 p.Gly113Arg Uncertain significance Single submitter
- CCL21 p.Gly121Val Uncertain significance Single submitter
- CCL21 p.Lys117Asn Uncertain significance Single submitter
- CCL21 p.Ser110Phe Uncertain significance Single submitter
- CCL21 p.Thr93Ala Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All CCL21 variants
Benign 1
- p.Pro96= Multiple submitters
Likely benign 2
- p.Arg127Gln Single submitter
- p.His89Arg Single submitter
Uncertain significance 14
- p.Ala42Ser Single submitter ⚠
- p.Ala72Glu Single submitter ⚠
- p.Arg49Gln Single submitter ⚠
- p.Arg67Leu Single submitter ⚠
- p.Gln129Glu Single submitter ⚠
- p.Gln3Arg Single submitter ⚠
- p.Glu126Lys Single submitter ⚠
- p.Gly113Arg Single submitter ⚠
- p.Gly121Val Single submitter ⚠
- p.Lys117Asn Single submitter ⚠
- p.Pro66His Single submitter ⚠
- p.Ser110Phe Single submitter ⚠
- p.Ser95Tyr Single submitter ⚠
- p.Thr93Ala Single submitter ⚠