CCL22 — 15 ClinVar variants
All ClinVar germline CCL22 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
3 Likely benign · 12 Uncertain significance
Full CCL22 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 10
The independent predictors disagree with each other — read with care.
- CCL22 p.Tyr40His Likely benign Multiple submitters
- CCL22 p.Arg38Cys Uncertain significance Single submitter
- CCL22 p.Arg3Cys Uncertain significance Single submitter
- CCL22 p.Arg48Cys Uncertain significance Single submitter
- CCL22 p.Arg48His Uncertain significance Single submitter
- CCL22 p.Glu23Lys Uncertain significance Single submitter
- CCL22 p.Pro79Ser Uncertain significance Single submitter
- CCL22 p.Pro82Leu Uncertain significance Single submitter
- CCL22 p.Tyr54Asn Uncertain significance Single submitter
- CCL22 p.Val13Ile Likely benign Single submitter
All CCL22 variants
Likely benign 3
- p.Tyr40His Multiple submitters ⚠
- p.Pro61= Single submitter
- p.Val13Ile Single submitter ⚠
Uncertain significance 12
- p.Arg38Cys Single submitter ⚠
- p.Arg38His Single submitter ⚠
- p.Arg3Cys Single submitter ⚠
- p.Arg42His Single submitter ⚠
- p.Arg44His Single submitter ⚠
- p.Arg48Cys Single submitter ⚠
- p.Arg48His Single submitter ⚠
- p.Asp78Asn Single submitter ⚠
- p.Glu23Lys Single submitter ⚠
- p.Pro79Ser Single submitter ⚠
- p.Pro82Leu Single submitter ⚠
- p.Tyr54Asn Single submitter ⚠