CCL23 — 28 ClinVar variants
All ClinVar germline CCL23 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
28 Uncertain significance
Full CCL23 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCL23 p.Ala66Val Uncertain significance Single submitter
- CCL23 p.Ala6Thr Uncertain significance Single submitter
- CCL23 p.Arg131Gln Uncertain significance Single submitter
- CCL23 p.Asp70Asn Uncertain significance Single submitter
- CCL23 p.Gln118Lys Uncertain significance Single submitter
- CCL23 p.Glu30Lys Uncertain significance Single submitter
- CCL23 p.Leu128Val Uncertain significance Single submitter
- CCL23 p.Met123Arg Uncertain significance Single submitter
- CCL23 p.Ser74Thr Uncertain significance Single submitter
- CCL23 p.Ser79Asn Uncertain significance Single submitter
- CCL23 p.Thr130Ile Uncertain significance Single submitter
- CCL23 p.Val42Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CCL23 p.Arg108Pro Uncertain significance Single submitter
- CCL23 p.Arg78Gln Uncertain significance Single submitter
- CCL23 p.Leu38Phe Uncertain significance Single submitter
- CCL23 p.Phe102Leu Uncertain significance Single submitter
- CCL23 p.Pro114Leu Uncertain significance Single submitter
- CCL23 p.Pro81Leu Uncertain significance Single submitter
- CCL23 p.Pro98Leu Uncertain significance Single submitter
- CCL23 p.Ser74Pro Uncertain significance Single submitter
- CCL23 p.Ser93Gly Uncertain significance Single submitter
- CCL23 p.Thr76Ala Uncertain significance Single submitter
- CCL23 p.Tyr75Asp Uncertain significance Single submitter
All CCL23 variants
Uncertain significance 28
- p.Ala66Val Single submitter ⚠
- p.Ala6Thr Single submitter ⚠
- p.Arg108Pro Single submitter ⚠
- p.Arg131Gln Single submitter ⚠
- p.Arg78Gln Single submitter ⚠
- p.Asp70Asn Single submitter ⚠
- p.Gln118Lys Single submitter ⚠
- p.Glu30Lys Single submitter ⚠
- p.His60Gln Single submitter
- p.Leu128Val Single submitter ⚠
- p.Leu38Phe Single submitter ⚠
- p.Met123Arg Single submitter ⚠
- p.Met46Ile Single submitter
- p.Phe102Leu Single submitter ⚠
- p.Pro114Leu Single submitter ⚠
- p.Pro54Ser Single submitter
- p.Pro81Leu Single submitter ⚠
- p.Pro98Leu Single submitter ⚠
- p.Ser74Pro Single submitter ⚠
- p.Ser74Thr Single submitter ⚠
- p.Ser79Asn Single submitter ⚠
- p.Ser93Gly Single submitter ⚠
- p.Thr130Ile Single submitter ⚠
- p.Thr76Ala Single submitter ⚠
- p.Trp48Arg Single submitter
- p.Tyr75Asp Single submitter ⚠
- p.Val42Ile Single submitter ⚠
- p.Arg78Ter No assertion criteria