CCL25 — 13 ClinVar variants
All ClinVar germline CCL25 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
1 Benign · 3 Likely benign · 9 Uncertain significance
Full CCL25 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCL25 p.Ala18Val Uncertain significance Single submitter
- CCL25 p.Arg44Gln Uncertain significance Single submitter
- CCL25 p.Asn103Ser Uncertain significance Single submitter
- CCL25 p.Ile38Val Uncertain significance Single submitter
- CCL25 p.Phe97Leu Uncertain significance Single submitter
- CCL25 p.Trp4Cys Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CCL25 variants
Benign 1
- p.Arg44Trp Multiple submitters ⚠
Likely benign 3
- p.Ala63Val Single submitter
- p.Leu3Pro Single submitter
- p.Thr106Asn Single submitter
Uncertain significance 9
- p.Ala18Val Single submitter ⚠
- p.Arg44Gln Single submitter ⚠
- p.Arg50Gln Single submitter ⚠
- p.Asn103Ser Single submitter ⚠
- p.Ile38Thr Single submitter ⚠
- p.Ile38Val Single submitter ⚠
- p.Phe97Leu Single submitter ⚠
- p.Trp4Cys Single submitter ⚠
- p.Tyr49Phe Single submitter ⚠