CCL26 — 14 ClinVar variants
All ClinVar germline CCL26 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
4 Likely benign · 10 Uncertain significance
Full CCL26 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCL26 p.His39Gln Uncertain significance Single submitter
- CCL26 p.Leu42Ile Uncertain significance Single submitter
- CCL26 p.Lys92Thr Uncertain significance Single submitter
- CCL26 p.Met2Ile Uncertain significance Single submitter
- CCL26 p.Met2Val Uncertain significance Single submitter
- CCL26 p.Thr45Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CCL26 variants
Likely benign 4
- c.74-10T>C Single submitter
- p.Arg48Gln Single submitter
- p.Lys78Glu Single submitter
- p.Pro91= Single submitter
Uncertain significance 10
- p.Arg60Trp Single submitter ⚠
- p.His39Gln Single submitter ⚠
- p.Leu42Ile Single submitter ⚠
- p.Lys92Thr Single submitter ⚠
- p.Met2Ile Single submitter ⚠
- p.Met2Val Single submitter ⚠
- p.Ser27Ile Single submitter ⚠
- p.Ser30Phe Single submitter ⚠
- p.Thr45Ile Single submitter ⚠
- p.Tyr50Asp Single submitter ⚠