CCL27 — 15 ClinVar variants
All ClinVar germline CCL27 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
1 Benign · 14 Uncertain significance
Full CCL27 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCL27 p.Arg109Trp Uncertain significance Single submitter
- CCL27 p.Cys34Tyr Uncertain significance Single submitter
- CCL27 p.Cys8Phe Uncertain significance Single submitter
- CCL27 p.Gln52Lys Uncertain significance Single submitter
- CCL27 p.Gly3Glu Uncertain significance Single submitter
- CCL27 p.Leu46Val Uncertain significance Single submitter
- CCL27 p.Leu69Phe Uncertain significance Single submitter
- CCL27 p.Lys2Thr Uncertain significance Single submitter
- CCL27 p.Val68Leu Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All CCL27 variants
Benign 1
- p.Ile78Val Multiple submitters
Uncertain significance 14
- p.Arg109Trp Single submitter ⚠
- p.Cys34Tyr Single submitter ⚠
- p.Cys8Phe Single submitter ⚠
- p.Gln52Lys Single submitter ⚠
- p.Gly3Glu Single submitter ⚠
- p.Leu37Phe Single submitter ⚠
- p.Leu46Val Single submitter ⚠
- p.Leu64Arg Single submitter ⚠
- p.Leu69Phe Single submitter ⚠
- p.Lys2Thr Single submitter ⚠
- p.Pro80Leu Single submitter ⚠
- p.Ser9Arg Single submitter ⚠
- p.Val68Leu Single submitter ⚠
- p.Val68Met Single submitter ⚠