CCL28 — 18 ClinVar variants
All ClinVar germline CCL28 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
1 Likely benign · 17 Uncertain significance
Full CCL28 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCL28 p.Arg50His Uncertain significance Single submitter
- CCL28 p.Arg70Gly Uncertain significance Single submitter
- CCL28 p.Asp59Asn Uncertain significance Single submitter
- CCL28 p.Cys73Ser Uncertain significance Single submitter
- CCL28 p.Gln2Leu Uncertain significance Single submitter
- CCL28 p.Glu119Lys Uncertain significance Single submitter
- CCL28 p.Gly106Val Uncertain significance Single submitter
- CCL28 p.His114Arg Uncertain significance Single submitter
- CCL28 p.His79Arg Uncertain significance Single submitter
- CCL28 p.Met48Lys Uncertain significance Single submitter
- CCL28 p.Ser110Gly Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CCL28 p.Ala7Thr Uncertain significance Single submitter
- CCL28 p.Arg50Cys Uncertain significance Single submitter
- CCL28 p.Arg69Cys Uncertain significance Single submitter
- CCL28 p.Arg69Leu Uncertain significance Single submitter
- CCL28 p.Val13Asp Uncertain significance Single submitter
- CCL28 p.Val46Leu Uncertain significance Single submitter
All CCL28 variants
Likely benign 1
- p.Tyr121His Single submitter
Uncertain significance 17
- p.Ala7Thr Single submitter ⚠
- p.Arg50Cys Single submitter ⚠
- p.Arg50His Single submitter ⚠
- p.Arg69Cys Single submitter ⚠
- p.Arg69Leu Single submitter ⚠
- p.Arg70Gly Single submitter ⚠
- p.Asp59Asn Single submitter ⚠
- p.Cys73Ser Single submitter ⚠
- p.Gln2Leu Single submitter ⚠
- p.Glu119Lys Single submitter ⚠
- p.Gly106Val Single submitter ⚠
- p.His114Arg Single submitter ⚠
- p.His79Arg Single submitter ⚠
- p.Met48Lys Single submitter ⚠
- p.Ser110Gly Single submitter ⚠
- p.Val13Asp Single submitter ⚠
- p.Val46Leu Single submitter ⚠