CCL3 — 13 ClinVar variants
All ClinVar germline CCL3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
2 Likely benign · 11 Uncertain significance
Full CCL3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 1
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 10
The independent predictors disagree with each other — read with care.
- CCL3 p.Ala27Pro Uncertain significance Single submitter
- CCL3 p.Arg40Trp Uncertain significance Single submitter
- CCL3 p.Arg68Gln Uncertain significance Single submitter
- CCL3 p.Gly61Val Uncertain significance Single submitter
- CCL3 p.Pro30Leu Uncertain significance Single submitter
- CCL3 p.Thr53Met Uncertain significance Single submitter
- CCL3 p.Tyr50Cys Uncertain significance Single submitter
- CCL3 p.Val62Ile Uncertain significance Single submitter
- CCL3 p.Val72Leu Uncertain significance Single submitter
- CCL3 p.Val72Phe Uncertain significance Single submitter
All CCL3 variants
Likely benign 2
- p.Ala48Val Single submitter
- p.Ser69Gly Single submitter
Uncertain significance 11
- p.Ala27Pro Single submitter ⚠
- p.Arg40Trp Single submitter ⚠
- p.Arg68Gln Single submitter ⚠
- p.Cys18Tyr Single submitter ⚠
- p.Gly61Val Single submitter ⚠
- p.Pro30Leu Single submitter ⚠
- p.Thr53Met Single submitter ⚠
- p.Tyr50Cys Single submitter ⚠
- p.Val62Ile Single submitter ⚠
- p.Val72Leu Single submitter ⚠
- p.Val72Phe Single submitter ⚠