CCL4 — 17 ClinVar variants
All ClinVar germline CCL4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
2 Likely benign · 15 Uncertain significance
Full CCL4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCL4 p.Ala40Ser Uncertain significance Single submitter
- CCL4 p.Ala40Thr Uncertain significance Single submitter
- CCL4 p.Gln66Glu Uncertain significance Single submitter
- CCL4 p.Phe17Leu Uncertain significance Single submitter
- CCL4 p.Ser70Arg Uncertain significance Single submitter
- CCL4 p.Tyr51Cys Uncertain significance Single submitter
- CCL4 p.Val7Ala Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CCL4 p.Ala40Val Likely benign Single submitter
- CCL4 p.Arg45Cys Uncertain significance Single submitter
- CCL4 p.Asp29Val Uncertain significance Single submitter
- CCL4 p.Asp88Val Uncertain significance Single submitter
- CCL4 p.Cys4Trp Uncertain significance Single submitter
- CCL4 p.Leu43Val Uncertain significance Single submitter
- CCL4 p.Phe47Leu Uncertain significance Single submitter
- CCL4 p.Ser37Cys Uncertain significance Single submitter
- CCL4 p.Tyr38His Uncertain significance Single submitter
- CCL4 p.Val86Met Likely benign Single submitter
All CCL4 variants
Likely benign 2
- p.Ala40Val Single submitter ⚠
- p.Val86Met Single submitter ⚠
Uncertain significance 15
- p.Ala40Ser Single submitter ⚠
- p.Ala40Thr Single submitter ⚠
- p.Arg45Cys Single submitter ⚠
- p.Asp29Val Single submitter ⚠
- p.Asp88Val Single submitter ⚠
- p.Cys4Trp Single submitter ⚠
- p.Gln66Glu Single submitter ⚠
- p.Leu43Val Single submitter ⚠
- p.Phe17Leu Single submitter ⚠
- p.Phe47Leu Single submitter ⚠
- p.Ser37Cys Single submitter ⚠
- p.Ser70Arg Single submitter ⚠
- p.Tyr38His Single submitter ⚠
- p.Tyr51Cys Single submitter ⚠
- p.Val7Ala Single submitter ⚠