CCL8 — 21 ClinVar variants
All ClinVar germline CCL8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
5 Benign · 1 Likely benign · 15 Uncertain significance
Full CCL8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 12
The independent predictors disagree with each other — read with care.
- CCL8 p.Ala15Val Uncertain significance Single submitter
- CCL8 p.Ala5Thr Uncertain significance Single submitter
- CCL8 p.Arg53Gly Uncertain significance Single submitter
- CCL8 p.Asp85Tyr Uncertain significance Single submitter
- CCL8 p.Gly21Glu Uncertain significance Single submitter
- CCL8 p.Ile30Phe Uncertain significance Single submitter
- CCL8 p.Met87Lys Uncertain significance Single submitter
- CCL8 p.Pro19Leu Uncertain significance Single submitter
- CCL8 p.Pro31Ala Uncertain significance Single submitter
- CCL8 p.Pro78Ser Uncertain significance Single submitter
- CCL8 p.Val64Met Uncertain significance Single submitter
- CCL8 p.Val74Phe Uncertain significance Single submitter
All CCL8 variants
Benign 5
- p.Ala14Val Multiple submitters
- p.Ile57= Multiple submitters
- p.Leu8= Multiple submitters
- p.Ser29= Multiple submitters
- c.195-8C>T Single submitter
Likely benign 1
- p.Arg47Lys Single submitter
Uncertain significance 15
- p.Ala15Val Single submitter ⚠
- p.Ala23Ser Single submitter ⚠
- p.Ala5Thr Single submitter ⚠
- p.Arg53Gly Single submitter ⚠
- p.Asp85Tyr Single submitter ⚠
- p.Gly21Glu Single submitter ⚠
- p.Ile30Phe Single submitter ⚠
- p.Ile32Val Single submitter ⚠
- p.Met87Lys Single submitter ⚠
- p.Pro19Leu Single submitter ⚠
- p.Pro25Thr Single submitter ⚠
- p.Pro31Ala Single submitter ⚠
- p.Pro78Ser Single submitter ⚠
- p.Val64Met Single submitter ⚠
- p.Val74Phe Single submitter ⚠