CCN4 — 89 ClinVar variants
All ClinVar germline CCN4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
3 Benign · 9 Likely benign · 77 Uncertain significance
Full CCN4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCN4 p.Ala196Thr Uncertain significance Single submitter
- CCN4 p.Ala243Ser Uncertain significance Single submitter
- CCN4 p.Ala354Val Uncertain significance Single submitter
- CCN4 p.Arg129His Uncertain significance Single submitter
- CCN4 p.Arg159Gln Uncertain significance Single submitter
- CCN4 p.Arg171Gln Uncertain significance Single submitter
- CCN4 p.Arg193Leu Uncertain significance Single submitter
- CCN4 p.Arg193Ser Uncertain significance Single submitter
- CCN4 p.Arg198His Uncertain significance Single submitter
- CCN4 p.Arg252Cys Uncertain significance Single submitter
- CCN4 p.Asn343His Uncertain significance Single submitter
- CCN4 p.Asp33Gly Uncertain significance Single submitter
- CCN4 p.Cys180Gly Uncertain significance Single submitter
- CCN4 p.Cys309Arg Uncertain significance Single submitter
- CCN4 p.Cys310Phe Uncertain significance Single submitter
- CCN4 p.Cys324Arg Uncertain significance Single submitter
- CCN4 p.Cys346Tyr Uncertain significance Single submitter
- CCN4 p.Glu186Gly Uncertain significance Single submitter
- CCN4 p.Gly201Arg Uncertain significance Single submitter
- CCN4 p.Gly207Asp Uncertain significance Single submitter
- CCN4 p.Ile112Thr Uncertain significance Single submitter
- CCN4 p.Ile291Phe Uncertain significance Single submitter
- CCN4 p.Ile365Thr Uncertain significance Single submitter
- CCN4 p.Met305Lys Uncertain significance Single submitter
- CCN4 p.Met32Ile Uncertain significance Single submitter
- CCN4 p.Pro163Leu Uncertain significance Single submitter
- CCN4 p.Pro192Ser Uncertain significance Single submitter
- CCN4 p.Pro247Leu Uncertain significance Single submitter
- CCN4 p.Ser44Leu Uncertain significance Single submitter
- CCN4 p.Thr13Ile Uncertain significance Single submitter
- CCN4 p.Thr200Arg Uncertain significance Single submitter
- CCN4 p.Val124Ile Uncertain significance Single submitter
Predictors split 47
The independent predictors disagree with each other — read with care.
- CCN4 p.Thr145Met Likely benign Multiple submitters
- CCN4 p.Ala10Glu Uncertain significance Single submitter
- CCN4 p.Ala10Thr Uncertain significance Single submitter
- CCN4 p.Ala17Ser Uncertain significance Single submitter
- CCN4 p.Ala288Val Uncertain significance Single submitter
- CCN4 p.Arg107His Uncertain significance Single submitter
- CCN4 p.Arg161Cys Uncertain significance Single submitter
- CCN4 p.Arg164Cys Uncertain significance Single submitter
- CCN4 p.Arg164His Uncertain significance Single submitter
- CCN4 p.Arg171Trp Uncertain significance Single submitter
- CCN4 p.Arg172His Uncertain significance Single submitter
- CCN4 p.Arg172Ser Uncertain significance Single submitter
- CCN4 p.Arg237Gln Uncertain significance Single submitter
- CCN4 p.Arg257Gln Uncertain significance Single submitter
- CCN4 p.Arg257Trp Uncertain significance Single submitter
- CCN4 p.Arg294Cys Uncertain significance Single submitter
- CCN4 p.Asn215Lys Uncertain significance Single submitter
- CCN4 p.Asn240Thr Uncertain significance Single submitter
- CCN4 p.Asn348Lys Uncertain significance Single submitter
- CCN4 p.Asn350Lys Uncertain significance Single submitter
- CCN4 p.Asn350Ser Uncertain significance Single submitter
- CCN4 p.Asn86Lys Uncertain significance Single submitter
- CCN4 p.Asp188Asn Uncertain significance Single submitter
- CCN4 p.Asp326Val Uncertain significance Single submitter
- CCN4 p.Asp85Asn Uncertain significance Single submitter
- CCN4 p.Gln134Arg Uncertain significance Single submitter
- CCN4 p.Glu186Lys Uncertain significance Single submitter
- CCN4 p.Gly105Arg Uncertain significance Single submitter
- CCN4 p.Gly133Ser Uncertain significance Single submitter
- CCN4 p.Gly149Ser Uncertain significance Single submitter
- CCN4 p.Gly231Ser Uncertain significance Single submitter
- CCN4 p.Ile112Arg Uncertain significance Single submitter
- CCN4 p.Ile175Lys Uncertain significance Single submitter
- CCN4 p.Leu68Ile Uncertain significance Single submitter
- CCN4 p.Pro108Leu Uncertain significance Single submitter
- CCN4 p.Pro138Ala Uncertain significance Single submitter
- CCN4 p.Pro170Leu Uncertain significance Single submitter
- CCN4 p.Pro176Ser Uncertain significance Single submitter
- CCN4 p.Pro63Leu Uncertain significance Single submitter
- CCN4 p.Ser224Asn Uncertain significance Single submitter
- CCN4 p.Thr23Met Likely benign Single submitter
- CCN4 p.Thr30Arg Uncertain significance Single submitter
- CCN4 p.Thr317Ser Uncertain significance Single submitter
- CCN4 p.Tyr100His Uncertain significance Single submitter
- CCN4 p.Val12Met Uncertain significance Single submitter
- CCN4 p.Val20Ile Uncertain significance Single submitter
- CCN4 p.Val320Met Uncertain significance Single submitter
All CCN4 variants
Likely benign 9
- p.Thr145Met Multiple submitters ⚠
- c.611-9C>T Single submitter
- p.Asn242= Single submitter
- p.Asp148= Single submitter
- p.Asp319Asn Single submitter
- p.Cys273= Single submitter
- p.Ile291= Single submitter
- p.Ser282= Single submitter
- p.Thr23Met Single submitter ⚠
Uncertain significance 77
- p.Ala10Glu Single submitter ⚠
- p.Ala10Thr Single submitter ⚠
- p.Ala17Ser Single submitter ⚠
- p.Ala196Thr Single submitter ⚠
- p.Ala243Ser Single submitter ⚠
- p.Ala288Val Single submitter ⚠
- p.Ala354Val Single submitter ⚠
- p.Arg107His Single submitter ⚠
- p.Arg129His Single submitter ⚠
- p.Arg159Gln Single submitter ⚠
- p.Arg161Cys Single submitter ⚠
- p.Arg164Cys Single submitter ⚠
- p.Arg164His Single submitter ⚠
- p.Arg171Gln Single submitter ⚠
- p.Arg171Trp Single submitter ⚠
- p.Arg172His Single submitter ⚠
- p.Arg172Ser Single submitter ⚠
- p.Arg193Leu Single submitter ⚠
- p.Arg193Ser Single submitter ⚠
- p.Arg198His Single submitter ⚠
- p.Arg237Gln Single submitter ⚠
- p.Arg252Cys Single submitter ⚠
- p.Arg257Gln Single submitter ⚠
- p.Arg257Trp Single submitter ⚠
- p.Arg294Cys Single submitter ⚠
- p.Asn215Lys Single submitter ⚠
- p.Asn240Thr Single submitter ⚠
- p.Asn343His Single submitter ⚠
- p.Asn348Lys Single submitter ⚠
- p.Asn350Lys Single submitter ⚠
- p.Asn350Ser Single submitter ⚠
- p.Asn86Lys Single submitter ⚠
- p.Asp188Asn Single submitter ⚠
- p.Asp326Val Single submitter ⚠
- p.Asp33Gly Single submitter ⚠
- p.Asp85Asn Single submitter ⚠
- p.Cys180Gly Single submitter ⚠
- p.Cys309Arg Single submitter ⚠
- p.Cys310Phe Single submitter ⚠
- p.Cys324Arg Single submitter ⚠
- p.Cys346Tyr Single submitter ⚠
- p.Gln134Arg Single submitter ⚠
- p.Glu186Gly Single submitter ⚠
- p.Glu186Lys Single submitter ⚠
- p.Gly105Arg Single submitter ⚠
- p.Gly133Ser Single submitter ⚠
- p.Gly149Ser Single submitter ⚠
- p.Gly201Arg Single submitter ⚠
- p.Gly207Asp Single submitter ⚠
- p.Gly231Ser Single submitter ⚠
- p.Ile112Arg Single submitter ⚠
- p.Ile112Thr Single submitter ⚠
- p.Ile175Lys Single submitter ⚠
- p.Ile291Phe Single submitter ⚠
- p.Ile365Thr Single submitter ⚠
- p.Leu68Ile Single submitter ⚠
- p.Met305Lys Single submitter ⚠
- p.Met32Ile Single submitter ⚠
- p.Pro108Leu Single submitter ⚠
- p.Pro138Ala Single submitter ⚠
- p.Pro163Leu Single submitter ⚠
- p.Pro170Leu Single submitter ⚠
- p.Pro176Ser Single submitter ⚠
- p.Pro192Ser Single submitter ⚠
- p.Pro247Leu Single submitter ⚠
- p.Pro63Leu Single submitter ⚠
- p.Ser224Asn Single submitter ⚠
- p.Ser44Leu Single submitter ⚠
- p.Thr13Ile Single submitter ⚠
- p.Thr200Arg Single submitter ⚠
- p.Thr30Arg Single submitter ⚠
- p.Thr317Ser Single submitter ⚠
- p.Tyr100His Single submitter ⚠
- p.Val124Ile Single submitter ⚠
- p.Val12Met Single submitter ⚠
- p.Val20Ile Single submitter ⚠
- p.Val320Met Single submitter ⚠