CCN5 — 66 ClinVar variants
All ClinVar germline CCN5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
2 Benign · 2 Likely benign · 62 Uncertain significance
Full CCN5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCN5 p.Ala72Thr Uncertain significance Single submitter
- CCN5 p.Arg22His Uncertain significance Single submitter
- CCN5 p.Arg230Pro Uncertain significance Single submitter
- CCN5 p.Arg243His Uncertain significance Single submitter
- CCN5 p.Arg38Gln Uncertain significance Single submitter
- CCN5 p.Arg58Gln Uncertain significance Single submitter
- CCN5 p.Arg87Gln Uncertain significance Single submitter
- CCN5 p.Asp97His Uncertain significance Single submitter
- CCN5 p.Cys163Trp Uncertain significance Single submitter
- CCN5 p.Cys30Arg Uncertain significance Single submitter
- CCN5 p.Cys32Ser Uncertain significance Single submitter
- CCN5 p.Gln114Lys Uncertain significance Single submitter
- CCN5 p.Gln165Glu Uncertain significance Single submitter
- CCN5 p.Gln172Lys Uncertain significance Single submitter
- CCN5 p.Gly110Val Uncertain significance Single submitter
- CCN5 p.Gly126Cys Uncertain significance Single submitter
- CCN5 p.Gly164Ser Uncertain significance Single submitter
- CCN5 p.Gly166Arg Uncertain significance Single submitter
- CCN5 p.Gly81Val Uncertain significance Single submitter
- CCN5 p.Phe113Ser Uncertain significance Single submitter
- CCN5 p.Pro115Ser Uncertain significance Single submitter
- CCN5 p.Pro193Thr Uncertain significance Single submitter
- CCN5 p.Pro239Ser Uncertain significance Single submitter
- CCN5 p.Ser118Gly Uncertain significance Single submitter
- CCN5 p.Thr4Pro Uncertain significance Single submitter
- CCN5 p.Val131Leu Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- CCN5 p.Ala11Asp Uncertain significance Single submitter
- CCN5 p.Ala213Thr Uncertain significance Single submitter
- CCN5 p.Arg105Ser Uncertain significance Single submitter
- CCN5 p.Arg215Trp Uncertain significance Single submitter
- CCN5 p.Arg221His Uncertain significance Single submitter
- CCN5 p.Arg229Cys Uncertain significance Single submitter
- CCN5 p.Arg230Cys Uncertain significance Single submitter
- CCN5 p.Arg243Cys Uncertain significance Single submitter
- CCN5 p.Asp65Asn Uncertain significance Single submitter
- CCN5 p.Asp71Asn Uncertain significance Single submitter
- CCN5 p.Gln74Glu Uncertain significance Single submitter
- CCN5 p.Gln74His Uncertain significance Single submitter
- CCN5 p.Gln79Leu Uncertain significance Single submitter
- CCN5 p.Glu160Val Uncertain significance Single submitter
- CCN5 p.Gly126Arg Uncertain significance Single submitter
- CCN5 p.Gly127Ser Uncertain significance Single submitter
- CCN5 p.Gly49Asp Uncertain significance Single submitter
- CCN5 p.Gly51Asp Uncertain significance Single submitter
- CCN5 p.Gly88Glu Uncertain significance Single submitter
- CCN5 p.Leu17Pro Uncertain significance Single submitter
- CCN5 p.Leu233Pro Uncertain significance Single submitter
- CCN5 p.Leu90Gln Uncertain significance Single submitter
- CCN5 p.Leu9Ile Uncertain significance Single submitter
- CCN5 p.Pro146Arg Uncertain significance Single submitter
- CCN5 p.Pro27Leu Uncertain significance Single submitter
- CCN5 p.Pro35Ala Uncertain significance Single submitter
- CCN5 p.Pro40Leu Uncertain significance Single submitter
- CCN5 p.Ser135Ile Uncertain significance Single submitter
- CCN5 p.Ser13Pro Uncertain significance Single submitter
- CCN5 p.Ser240Phe Uncertain significance Single submitter
- CCN5 p.Thr199Met Uncertain significance Single submitter
- CCN5 p.Thr207Ile Uncertain significance Single submitter
- CCN5 p.Val216Ala Uncertain significance Single submitter
- CCN5 p.Val43Ile Uncertain significance Single submitter
- CCN5 p.Val55Leu Uncertain significance Single submitter
- CCN5 p.Val69Ile Uncertain significance Single submitter
All CCN5 variants
Likely benign 2
- p.Arg108Gln Single submitter
- p.Pro84= Single submitter
Uncertain significance 62
- p.Ala11Asp Single submitter ⚠
- p.Ala213Thr Single submitter ⚠
- p.Ala72Thr Single submitter ⚠
- p.Arg105Ser Single submitter ⚠
- p.Arg215Trp Single submitter ⚠
- p.Arg221His Single submitter ⚠
- p.Arg229Cys Single submitter ⚠
- p.Arg22His Single submitter ⚠
- p.Arg230Cys Single submitter ⚠
- p.Arg230Pro Single submitter ⚠
- p.Arg243Cys Single submitter ⚠
- p.Arg243His Single submitter ⚠
- p.Arg38Gln Single submitter ⚠
- p.Arg58Gln Single submitter ⚠
- p.Arg87Gln Single submitter ⚠
- p.Asp65Asn Single submitter ⚠
- p.Asp71Asn Single submitter ⚠
- p.Asp97His Single submitter ⚠
- p.Cys163Trp Single submitter ⚠
- p.Cys30Arg Single submitter ⚠
- p.Cys32Ser Single submitter ⚠
- p.Gln114Lys Single submitter ⚠
- p.Gln165Glu Single submitter ⚠
- p.Gln172Lys Single submitter ⚠
- p.Gln74Glu Single submitter ⚠
- p.Gln74His Single submitter ⚠
- p.Gln79Leu Single submitter ⚠
- p.Glu160Val Single submitter ⚠
- p.Gly110Val Single submitter ⚠
- p.Gly126Arg Single submitter ⚠
- p.Gly126Cys Single submitter ⚠
- p.Gly127Ser Single submitter ⚠
- p.Gly164Ser Single submitter ⚠
- p.Gly166Arg Single submitter ⚠
- p.Gly49Asp Single submitter ⚠
- p.Gly51Asp Single submitter ⚠
- p.Gly81Val Single submitter ⚠
- p.Gly88Glu Single submitter ⚠
- p.Leu17Pro Single submitter ⚠
- p.Leu233Pro Single submitter ⚠
- p.Leu90Gln Single submitter ⚠
- p.Leu9Ile Single submitter ⚠
- p.Phe113Ser Single submitter ⚠
- p.Pro115Ser Single submitter ⚠
- p.Pro146Arg Single submitter ⚠
- p.Pro193Thr Single submitter ⚠
- p.Pro239Ser Single submitter ⚠
- p.Pro27Leu Single submitter ⚠
- p.Pro35Ala Single submitter ⚠
- p.Pro40Leu Single submitter ⚠
- p.Ser118Gly Single submitter ⚠
- p.Ser135Ile Single submitter ⚠
- p.Ser13Pro Single submitter ⚠
- p.Ser240Phe Single submitter ⚠
- p.Thr199Met Single submitter ⚠
- p.Thr207Ile Single submitter ⚠
- p.Thr4Pro Single submitter ⚠
- p.Val131Leu Single submitter ⚠
- p.Val216Ala Single submitter ⚠
- p.Val43Ile Single submitter ⚠
- p.Val55Leu Single submitter ⚠
- p.Val69Ile Single submitter ⚠