CCNA2 — 33 ClinVar variants
All ClinVar germline CCNA2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
5 Benign · 3 Likely benign · 25 Uncertain significance
Full CCNA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCNA2 p.Ala131Val Uncertain significance Single submitter
- CCNA2 p.Asn34Lys Uncertain significance Single submitter
- CCNA2 p.Gln22His Uncertain significance Single submitter
- CCNA2 p.Gln42Arg Uncertain significance Single submitter
- CCNA2 p.Glu109Ala Uncertain significance Single submitter
- CCNA2 p.Glu374Gln Uncertain significance Single submitter
- CCNA2 p.His84Pro Uncertain significance Single submitter
- CCNA2 p.Ile162Thr Uncertain significance Single submitter
- CCNA2 p.Ile270Leu Uncertain significance Single submitter
- CCNA2 p.Ile355Val Uncertain significance Single submitter
- CCNA2 p.Ile409Val Uncertain significance Single submitter
- CCNA2 p.Pro40Leu Uncertain significance Single submitter
- CCNA2 p.Pro89Leu Uncertain significance Single submitter
- CCNA2 p.Ser171Asn Uncertain significance Single submitter
- CCNA2 p.Ser375Thr Uncertain significance Single submitter
- CCNA2 p.Val215Met Uncertain significance Single submitter
- CCNA2 p.Val275Ala Uncertain significance Single submitter
- CCNA2 p.Val87Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CCNA2 p.Arg122Cys Likely benign Single submitter
- CCNA2 p.Arg45Gly Uncertain significance Single submitter
- CCNA2 p.Cys193Arg Uncertain significance Single submitter
- CCNA2 p.Ile342Thr Uncertain significance Single submitter
- CCNA2 p.Leu387Phe Uncertain significance Single submitter
- CCNA2 p.Leu399Val Uncertain significance Single submitter
- CCNA2 p.Pro140Leu Uncertain significance Single submitter
All CCNA2 variants
Benign 5
- c.*828C>G Multiple submitters
- p.Leu126= Multiple submitters
- p.Lys112Glu Multiple submitters
- p.Pro74= Multiple submitters
- p.Ile163= Single submitter
Likely benign 3
- p.Ala110Thr Single submitter
- p.Arg122Cys Single submitter ⚠
- p.Arg378Gln Single submitter
Uncertain significance 25
- p.Ala131Val Single submitter ⚠
- p.Arg45Gly Single submitter ⚠
- p.Asn34Lys Single submitter ⚠
- p.Cys193Arg Single submitter ⚠
- p.Gln22His Single submitter ⚠
- p.Gln42Arg Single submitter ⚠
- p.Glu109Ala Single submitter ⚠
- p.Glu374Gln Single submitter ⚠
- p.His84Pro Single submitter ⚠
- p.Ile162Thr Single submitter ⚠
- p.Ile270Leu Single submitter ⚠
- p.Ile342Thr Single submitter ⚠
- p.Ile355Val Single submitter ⚠
- p.Ile409Val Single submitter ⚠
- p.Leu387Phe Single submitter ⚠
- p.Leu399Val Single submitter ⚠
- p.Pro140Leu Single submitter ⚠
- p.Pro40Leu Single submitter ⚠
- p.Pro89Leu Single submitter ⚠
- p.Ser171Asn Single submitter ⚠
- p.Ser375Thr Single submitter ⚠
- p.Val215Met Single submitter ⚠
- p.Val275Ala Single submitter ⚠
- p.Val87Ile Single submitter ⚠
- c.214-3_214-2insN No assertion criteria