CCNB1 — 52 ClinVar variants
All ClinVar germline CCNB1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
2 Likely benign · 50 Uncertain significance
Full CCNB1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCNB1 p.Ala125Ser Uncertain significance Single submitter
- CCNB1 p.Ala152Val Uncertain significance Single submitter
- CCNB1 p.Ala17Thr Uncertain significance Single submitter
- CCNB1 p.Ala22Thr Uncertain significance Single submitter
- CCNB1 p.Ala24Val Uncertain significance Single submitter
- CCNB1 p.Ala348Thr Uncertain significance Single submitter
- CCNB1 p.Arg307Gln Uncertain significance Single submitter
- CCNB1 p.Asn12Asp Uncertain significance Single submitter
- CCNB1 p.Asp207His Uncertain significance Single submitter
- CCNB1 p.Gly23Ser Uncertain significance Single submitter
- CCNB1 p.His304Pro Uncertain significance Single submitter
- CCNB1 p.Leu332Met Uncertain significance Single submitter
- CCNB1 p.Leu56Val Uncertain significance Single submitter
- CCNB1 p.Met285Val Uncertain significance Single submitter
- CCNB1 p.Met398Val Uncertain significance Single submitter
- CCNB1 p.Met62Ile Uncertain significance Single submitter
- CCNB1 p.Met62Thr Uncertain significance Single submitter
- CCNB1 p.Met62Val Uncertain significance Single submitter
- CCNB1 p.Met88Thr Uncertain significance Single submitter
- CCNB1 p.Pro31Ser Uncertain significance Single submitter
- CCNB1 p.Val388Ala Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- CCNB1 p.Ala203Thr Uncertain significance Multiple submitters
- CCNB1 p.Ala176Val Uncertain significance Single submitter
- CCNB1 p.Arg195Trp Uncertain significance Single submitter
- CCNB1 p.Arg299Trp Uncertain significance Single submitter
- CCNB1 p.Asn12Lys Uncertain significance Single submitter
- CCNB1 p.Asp163Glu Uncertain significance Single submitter
- CCNB1 p.Asp335Tyr Uncertain significance Single submitter
- CCNB1 p.Gln424Lys Uncertain significance Single submitter
- CCNB1 p.Glu14Gln Uncertain significance Single submitter
- CCNB1 p.Ile11Phe Uncertain significance Single submitter
- CCNB1 p.Ile230Met Uncertain significance Single submitter
- CCNB1 p.Ile230Thr Uncertain significance Single submitter
- CCNB1 p.Leu301Val Uncertain significance Single submitter
- CCNB1 p.Leu394Val Uncertain significance Single submitter
- CCNB1 p.Leu83Phe Uncertain significance Single submitter
- CCNB1 p.Met223Val Uncertain significance Single submitter
- CCNB1 p.Met234Val Uncertain significance Single submitter
- CCNB1 p.Met261Ile Uncertain significance Single submitter
- CCNB1 p.Pro107Ala Uncertain significance Single submitter
- CCNB1 p.Pro28Leu Uncertain significance Single submitter
- CCNB1 p.Pro37Leu Uncertain significance Single submitter
- CCNB1 p.Pro87Ser Uncertain significance Single submitter
- CCNB1 p.Ser407Leu Uncertain significance Single submitter
- CCNB1 p.Ser420Cys Uncertain significance Single submitter
- CCNB1 p.Ser420Tyr Uncertain significance Single submitter
- CCNB1 p.Thr330Ile Uncertain significance Single submitter
- CCNB1 p.Thr395Arg Uncertain significance Single submitter
- CCNB1 p.Thr395Lys Uncertain significance Single submitter
- CCNB1 p.Thr6Ser Uncertain significance Single submitter
All CCNB1 variants
Likely benign 2
- p.Leu56Pro Single submitter
- p.Val400Ile Single submitter
Uncertain significance 50
- p.Ala203Thr Multiple submitters ⚠
- p.Ala125Ser Single submitter ⚠
- p.Ala152Val Single submitter ⚠
- p.Ala176Val Single submitter ⚠
- p.Ala17Thr Single submitter ⚠
- p.Ala22Thr Single submitter ⚠
- p.Ala24Val Single submitter ⚠
- p.Ala348Thr Single submitter ⚠
- p.Arg195Trp Single submitter ⚠
- p.Arg299Trp Single submitter ⚠
- p.Arg307Gln Single submitter ⚠
- p.Asn12Asp Single submitter ⚠
- p.Asn12Lys Single submitter ⚠
- p.Asp163Glu Single submitter ⚠
- p.Asp207His Single submitter ⚠
- p.Asp335Tyr Single submitter ⚠
- p.Gln424Lys Single submitter ⚠
- p.Glu14Gln Single submitter ⚠
- p.Gly23Ser Single submitter ⚠
- p.His304Pro Single submitter ⚠
- p.Ile11Phe Single submitter ⚠
- p.Ile230Met Single submitter ⚠
- p.Ile230Thr Single submitter ⚠
- p.Leu301Val Single submitter ⚠
- p.Leu332Met Single submitter ⚠
- p.Leu394Val Single submitter ⚠
- p.Leu56Val Single submitter ⚠
- p.Leu83Phe Single submitter ⚠
- p.Met223Val Single submitter ⚠
- p.Met234Val Single submitter ⚠
- p.Met261Ile Single submitter ⚠
- p.Met285Val Single submitter ⚠
- p.Met398Val Single submitter ⚠
- p.Met62Ile Single submitter ⚠
- p.Met62Thr Single submitter ⚠
- p.Met62Val Single submitter ⚠
- p.Met88Thr Single submitter ⚠
- p.Pro107Ala Single submitter ⚠
- p.Pro28Leu Single submitter ⚠
- p.Pro31Ser Single submitter ⚠
- p.Pro37Leu Single submitter ⚠
- p.Pro87Ser Single submitter ⚠
- p.Ser407Leu Single submitter ⚠
- p.Ser420Cys Single submitter ⚠
- p.Ser420Tyr Single submitter ⚠
- p.Thr330Ile Single submitter ⚠
- p.Thr395Arg Single submitter ⚠
- p.Thr395Lys Single submitter ⚠
- p.Thr6Ser Single submitter ⚠
- p.Val388Ala Single submitter ⚠