CCNB2 — 62 ClinVar variants
All ClinVar germline CCNB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
3 Benign · 5 Likely benign · 54 Uncertain significance
Full CCNB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCNB2 p.Ala112Gly Uncertain significance Single submitter
- CCNB2 p.Ala46Thr Uncertain significance Single submitter
- CCNB2 p.Arg164His Uncertain significance Single submitter
- CCNB2 p.Arg196Gln Uncertain significance Single submitter
- CCNB2 p.Arg205Trp Uncertain significance Single submitter
- CCNB2 p.Asn69Lys Uncertain significance Single submitter
- CCNB2 p.Asp171Ala Uncertain significance Single submitter
- CCNB2 p.Asp232Ala Uncertain significance Single submitter
- CCNB2 p.Asp238Asn Uncertain significance Single submitter
- CCNB2 p.Glu260Gln Uncertain significance Single submitter
- CCNB2 p.Glu292Asp Uncertain significance Single submitter
- CCNB2 p.Gly90Val Uncertain significance Single submitter
- CCNB2 p.His154Arg Uncertain significance Single submitter
- CCNB2 p.Ile161Thr Uncertain significance Single submitter
- CCNB2 p.Leu218Phe Uncertain significance Single submitter
- CCNB2 p.Lys324Arg Uncertain significance Single submitter
- CCNB2 p.Met100Ile Uncertain significance Single submitter
- CCNB2 p.Met165Ile Uncertain significance Single submitter
- CCNB2 p.Met249Val Uncertain significance Single submitter
- CCNB2 p.Phe233Ser Uncertain significance Single submitter
- CCNB2 p.Thr18Ile Uncertain significance Single submitter
- CCNB2 p.Thr29Pro Uncertain significance Single submitter
- CCNB2 p.Val174Ile Uncertain significance Single submitter
- CCNB2 p.Val20Gly Uncertain significance Single submitter
- CCNB2 p.Val9Leu Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- CCNB2 p.Ala167Thr Uncertain significance Single submitter
- CCNB2 p.Arg164Cys Uncertain significance Single submitter
- CCNB2 p.Arg45Lys Uncertain significance Single submitter
- CCNB2 p.Asn350Asp Uncertain significance Single submitter
- CCNB2 p.Asn67His Uncertain significance Single submitter
- CCNB2 p.Gln184His Uncertain significance Single submitter
- CCNB2 p.Gln317Glu Uncertain significance Single submitter
- CCNB2 p.Gln345His Uncertain significance Single submitter
- CCNB2 p.Glu260Ala Uncertain significance Single submitter
- CCNB2 p.Ile161Val Uncertain significance Single submitter
- CCNB2 p.Ile230Thr Uncertain significance Single submitter
- CCNB2 p.Leu293Met Uncertain significance Single submitter
- CCNB2 p.Lys307Asn Uncertain significance Single submitter
- CCNB2 p.Lys365Thr Uncertain significance Single submitter
- CCNB2 p.Lys57Ile Uncertain significance Single submitter
- CCNB2 p.Met194Thr Uncertain significance Single submitter
- CCNB2 p.Met300Thr Uncertain significance Single submitter
- CCNB2 p.Phe361Cys Uncertain significance Single submitter
- CCNB2 p.Pro202Thr Uncertain significance Single submitter
- CCNB2 p.Pro80Leu Uncertain significance Single submitter
- CCNB2 p.Ser150Cys Uncertain significance Single submitter
- CCNB2 p.Thr285Ala Uncertain significance Single submitter
- CCNB2 p.Thr333Ile Uncertain significance Single submitter
- CCNB2 p.Thr359Ile Uncertain significance Single submitter
- CCNB2 p.Thr43Lys Uncertain significance Single submitter
- CCNB2 p.Thr44Ile Uncertain significance Single submitter
- CCNB2 p.Thr65Ile Uncertain significance Single submitter
- CCNB2 p.Tyr139Cys Uncertain significance Single submitter
- CCNB2 p.Val170Ala Uncertain significance Single submitter
All CCNB2 variants
Benign 3
- p.Ile395Thr Multiple submitters
- p.Lys89= Multiple submitters
- p.Met100Thr Multiple submitters
Likely benign 5
- p.Ile296= Single submitter
- p.Pro95= Single submitter
- p.Ser274= Single submitter
- p.Val387Ile Single submitter
- p.Val98Ile Single submitter
Uncertain significance 54
- p.Ala112Gly Single submitter ⚠
- p.Ala167Thr Single submitter ⚠
- p.Ala46Thr Single submitter ⚠
- p.Arg164Cys Single submitter ⚠
- p.Arg164His Single submitter ⚠
- p.Arg196Gln Single submitter ⚠
- p.Arg205Trp Single submitter ⚠
- p.Arg45Lys Single submitter ⚠
- p.Asn350Asp Single submitter ⚠
- p.Asn67His Single submitter ⚠
- p.Asn69Lys Single submitter ⚠
- p.Asp171Ala Single submitter ⚠
- p.Asp232Ala Single submitter ⚠
- p.Asp238Asn Single submitter ⚠
- p.Gln184His Single submitter ⚠
- p.Gln317Glu Single submitter ⚠
- p.Gln345His Single submitter ⚠
- p.Glu260Ala Single submitter ⚠
- p.Glu260Gln Single submitter ⚠
- p.Glu292Asp Single submitter ⚠
- p.Gly90Val Single submitter ⚠
- p.His154Arg Single submitter ⚠
- p.Ile161Thr Single submitter ⚠
- p.Ile161Val Single submitter ⚠
- p.Ile230Thr Single submitter ⚠
- p.Leu218Phe Single submitter ⚠
- p.Leu293Met Single submitter ⚠
- p.Lys307Asn Single submitter ⚠
- p.Lys324Arg Single submitter ⚠
- p.Lys365Thr Single submitter ⚠
- p.Lys57Ile Single submitter ⚠
- p.Met100Ile Single submitter ⚠
- p.Met165Ile Single submitter ⚠
- p.Met194Thr Single submitter ⚠
- p.Met249Val Single submitter ⚠
- p.Met300Thr Single submitter ⚠
- p.Phe233Ser Single submitter ⚠
- p.Phe361Cys Single submitter ⚠
- p.Pro202Thr Single submitter ⚠
- p.Pro80Leu Single submitter ⚠
- p.Ser150Cys Single submitter ⚠
- p.Thr18Ile Single submitter ⚠
- p.Thr285Ala Single submitter ⚠
- p.Thr29Pro Single submitter ⚠
- p.Thr333Ile Single submitter ⚠
- p.Thr359Ile Single submitter ⚠
- p.Thr43Lys Single submitter ⚠
- p.Thr44Ile Single submitter ⚠
- p.Thr65Ile Single submitter ⚠
- p.Tyr139Cys Single submitter ⚠
- p.Val170Ala Single submitter ⚠
- p.Val174Ile Single submitter ⚠
- p.Val20Gly Single submitter ⚠
- p.Val9Leu Single submitter ⚠