CCNB3 — 147 ClinVar variants
All ClinVar germline CCNB3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 122 flagged for review →
1 Pathogenic · 4 Likely pathogenic · 3 Conflicting · 5 Benign · 25 Likely benign · 109 Uncertain significance
Full CCNB3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 122
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 5
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
-
CCNB3 p.Glu116Ala
Likely pathogenic
No assertion criteria
female infertility
-
CCNB3 p.Glu221Ala
Likely pathogenic
No assertion criteria
female infertility
-
CCNB3 p.Pro1223Leu
Likely pathogenic
No assertion criteria
female infertility
-
CCNB3 p.Ser1353Asn
Likely pathogenic
No assertion criteria
female infertility
-
CCNB3 p.Val1251Asp
Pathogenic
No assertion criteria
pregnancy loss, recurrent, susceptibility to, 1
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCNB3 p.Ala1208Thr Uncertain significance Single submitter
- CCNB3 p.Ala312Pro Uncertain significance Single submitter
- CCNB3 p.Ala437Ser Uncertain significance Single submitter
- CCNB3 p.Ala981Thr Uncertain significance Single submitter
- CCNB3 p.Arg1113Gln Uncertain significance Single submitter
- CCNB3 p.Arg1113Pro Uncertain significance Single submitter
- CCNB3 p.Arg1224His Uncertain significance Single submitter
- CCNB3 p.Arg1283His Uncertain significance Single submitter
- CCNB3 p.Asn684Ser Uncertain significance Single submitter
- CCNB3 p.Asp1096His Uncertain significance Single submitter
- CCNB3 p.Asp1117Glu Uncertain significance Single submitter
- CCNB3 p.Asp168Asn Uncertain significance Single submitter
- CCNB3 p.Asp554Ala Uncertain significance Single submitter
- CCNB3 p.Cys1039Phe Uncertain significance Single submitter
- CCNB3 p.Cys236Tyr Uncertain significance Single submitter
- CCNB3 p.Cys290Tyr Uncertain significance Single submitter
- CCNB3 p.Cys546Ser Uncertain significance Single submitter
- CCNB3 p.Gln47Arg Uncertain significance Single submitter
- CCNB3 p.Glu48Gly Uncertain significance Single submitter
- CCNB3 p.Glu558Gly Uncertain significance Single submitter
- CCNB3 p.Gly787Glu Uncertain significance Single submitter
- CCNB3 p.Gly787Val Uncertain significance Single submitter
- CCNB3 p.His1294Arg Uncertain significance Single submitter
- CCNB3 p.His217Arg Uncertain significance Single submitter
- CCNB3 p.Ile224Val Uncertain significance Single submitter
- CCNB3 p.Ile420Val Uncertain significance Single submitter
- CCNB3 p.Leu100Phe Uncertain significance Single submitter
- CCNB3 p.Leu362Phe Uncertain significance Single submitter
- CCNB3 p.Met1177Val Uncertain significance Single submitter
- CCNB3 p.Met235Ile Uncertain significance Single submitter
- CCNB3 p.Met568Ile Uncertain significance Single submitter
- CCNB3 p.Met918Leu Uncertain significance Single submitter
- CCNB3 p.Met918Val Uncertain significance Single submitter
- CCNB3 p.Phe1366Ser Uncertain significance Single submitter
- CCNB3 p.Phe777Leu Uncertain significance Single submitter
- CCNB3 p.Pro279Leu Uncertain significance Single submitter
- CCNB3 p.Ser230Pro Uncertain significance Single submitter
- CCNB3 p.Ser30Pro Uncertain significance Single submitter
- CCNB3 p.Ser42Pro Uncertain significance Single submitter
- CCNB3 p.Ser585Leu Uncertain significance Single submitter
- CCNB3 p.Ser748Pro Uncertain significance Single submitter
- CCNB3 p.Ser753Cys Uncertain significance Single submitter
- CCNB3 p.Thr39Arg Uncertain significance Single submitter
- CCNB3 p.Thr474Ile Uncertain significance Single submitter
- CCNB3 p.Thr97Ile Uncertain significance Single submitter
- CCNB3 p.Trp881Arg Uncertain significance Single submitter
- CCNB3 p.Val121Leu Uncertain significance Single submitter
- CCNB3 p.Val251Met Uncertain significance Single submitter
Predictors split 69
The independent predictors disagree with each other — read with care.
- CCNB3 p.Lys857Gln Likely benign Multiple submitters
- CCNB3 p.Ser188Thr Benign Multiple submitters
- CCNB3 p.Arg1083Lys Uncertain significance Single submitter
- CCNB3 p.Arg1266Cys Uncertain significance Single submitter
- CCNB3 p.Arg1266His Uncertain significance Single submitter
- CCNB3 p.Asn934Ile Uncertain significance Single submitter
- CCNB3 p.Asp253His Uncertain significance Single submitter
- CCNB3 p.Glu149Ala Uncertain significance Single submitter
- CCNB3 p.Glu209Gln Uncertain significance Single submitter
- CCNB3 p.Glu257Lys Uncertain significance Single submitter
- CCNB3 p.Glu264Lys Uncertain significance Single submitter
- CCNB3 p.Glu324Gly Uncertain significance Single submitter
- CCNB3 p.Glu410Asp Uncertain significance Single submitter
- CCNB3 p.Glu434Asp Uncertain significance Single submitter
- CCNB3 p.Glu464Gln Uncertain significance Single submitter
- CCNB3 p.Glu644Asp Uncertain significance Single submitter
- CCNB3 p.Glu692Asp Uncertain significance Single submitter
- CCNB3 p.Glu942Lys Uncertain significance Single submitter
- CCNB3 p.Glu942Val Uncertain significance Single submitter
- CCNB3 p.Gly515Arg Conflicting Single submitter
- CCNB3 p.His298Arg Conflicting Single submitter
- CCNB3 p.Ile509Met Uncertain significance Single submitter
- CCNB3 p.Ile772Val Uncertain significance Single submitter
- CCNB3 p.Ile991Val Uncertain significance Single submitter
- CCNB3 p.Leu1308Phe Likely benign Single submitter
- CCNB3 p.Leu1312Val Uncertain significance Single submitter
- CCNB3 p.Leu385Met Uncertain significance Single submitter
- CCNB3 p.Leu581Ile Uncertain significance Single submitter
- CCNB3 p.Leu605Gln Uncertain significance Single submitter
- CCNB3 p.Leu797Ile Uncertain significance Single submitter
- CCNB3 p.Leu816Val Uncertain significance Single submitter
- CCNB3 p.Leu833Ser Uncertain significance Single submitter
- CCNB3 p.Lys1081Arg Uncertain significance Single submitter
- CCNB3 p.Lys144Gln Uncertain significance Single submitter
- CCNB3 p.Lys287Arg Uncertain significance Single submitter
- CCNB3 p.Lys440Thr Uncertain significance Single submitter
- CCNB3 p.Lys492Asn Uncertain significance Single submitter
- CCNB3 p.Lys591Asn Uncertain significance Single submitter
- CCNB3 p.Lys846Arg Uncertain significance Single submitter
- CCNB3 p.Met1076Val Uncertain significance Single submitter
- CCNB3 p.Met568Thr Uncertain significance Single submitter
- CCNB3 p.Met598Thr Uncertain significance Single submitter
- CCNB3 p.Phe467Cys Uncertain significance Single submitter
- CCNB3 p.Phe962Leu Uncertain significance Single submitter
- CCNB3 p.Pro1030Ser Uncertain significance Single submitter
- CCNB3 p.Pro1051Ser Uncertain significance Single submitter
- CCNB3 p.Pro164Leu Uncertain significance Single submitter
- CCNB3 p.Pro969Ser Uncertain significance Single submitter
- CCNB3 p.Pro982Leu Uncertain significance Single submitter
- CCNB3 p.Ser1056Arg Uncertain significance Single submitter
- CCNB3 p.Ser267Asn Likely benign Single submitter
- CCNB3 p.Ser408Cys Uncertain significance Single submitter
- CCNB3 p.Ser449Phe Uncertain significance Single submitter
- CCNB3 p.Ser717Ile Uncertain significance Single submitter
- CCNB3 p.Ser809Arg Uncertain significance Single submitter
- CCNB3 p.Ser809Asn Uncertain significance Single submitter
- CCNB3 p.Ser919Pro Uncertain significance Single submitter
- CCNB3 p.Thr1043Ile Uncertain significance Single submitter
- CCNB3 p.Thr497Pro Uncertain significance Single submitter
- CCNB3 p.Thr630Met Uncertain significance Single submitter
- CCNB3 p.Thr908Pro Uncertain significance Single submitter
- CCNB3 p.Thr961Ile Uncertain significance Single submitter
- CCNB3 p.Thr980Ile Uncertain significance Single submitter
- CCNB3 p.Tyr1058Cys Uncertain significance Single submitter
- CCNB3 p.Val1079Leu Uncertain significance Single submitter
- CCNB3 p.Val1079Met Conflicting Single submitter
- CCNB3 p.Val126Met Likely benign Single submitter
- CCNB3 p.Val1369Ile Uncertain significance Single submitter
- CCNB3 p.Val997Ala Uncertain significance Single submitter
All CCNB3 variants
Pathogenic 1
- p.Val1251Asp No assertion criteria pregnancy loss, recurrent, susceptibility to, 1 ⚠
Likely pathogenic 4
- p.Glu116Ala No assertion criteria female infertility ⚠
- p.Glu221Ala No assertion criteria female infertility ⚠
- p.Pro1223Leu No assertion criteria female infertility ⚠
- p.Ser1353Asn No assertion criteria female infertility ⚠
Conflicting classifications of pathogenicity 3
- p.Gly515Arg Single submitter ⚠
- p.His298Arg Single submitter ⚠
- p.Val1079Met Single submitter ⚠
Benign 5
- p.Ala702= Multiple submitters
- p.Gly1001Arg Multiple submitters
- p.Ser188Thr Multiple submitters ⚠
- p.Asn255= Single submitter
- p.Ser1301= Single submitter
Likely benign 25
- p.Lys857Gln Multiple submitters ⚠
- c.4092-6T>C Single submitter
- p.Ala702Thr Single submitter
- p.Ala792= Single submitter
- p.Arg1113Trp Single submitter
- p.Arg397Cys Single submitter
- p.Glu715= Single submitter
- p.Glu807Lys Single submitter
- p.Ile1053Val Single submitter
- p.Ile1272Val Single submitter
- p.Ile166Thr Single submitter
- p.Ile278Thr Single submitter
- p.Leu1308Phe Single submitter ⚠
- p.Leu729= Single submitter
- p.Lys107Glu Single submitter
- p.Met568Val Single submitter
- p.Phe85= Single submitter
- p.Pro195Ser Single submitter
- p.Pro483Thr Single submitter
- p.Ser248= Single submitter
- p.Ser248Leu Single submitter
- p.Ser267Asn Single submitter ⚠
- p.Ser455= Single submitter
- p.Val1197Ile Single submitter
- p.Val126Met Single submitter ⚠
Uncertain significance 109
- p.Ala1208Thr Single submitter ⚠
- p.Ala312Pro Single submitter ⚠
- p.Ala437Ser Single submitter ⚠
- p.Ala981Thr Single submitter ⚠
- p.Arg1083Lys Single submitter ⚠
- p.Arg1113Gln Single submitter ⚠
- p.Arg1113Pro Single submitter ⚠
- p.Arg1224His Single submitter ⚠
- p.Arg1266Cys Single submitter ⚠
- p.Arg1266His Single submitter ⚠
- p.Arg1283His Single submitter ⚠
- p.Asn684Ser Single submitter ⚠
- p.Asn934Ile Single submitter ⚠
- p.Asp1096His Single submitter ⚠
- p.Asp1117Glu Single submitter ⚠
- p.Asp168Asn Single submitter ⚠
- p.Asp253His Single submitter ⚠
- p.Asp554Ala Single submitter ⚠
- p.Cys1039Phe Single submitter ⚠
- p.Cys236Tyr Single submitter ⚠
- p.Cys290Tyr Single submitter ⚠
- p.Cys546Ser Single submitter ⚠
- p.Gln47Arg Single submitter ⚠
- p.Glu149Ala Single submitter ⚠
- p.Glu209Gln Single submitter ⚠
- p.Glu257Lys Single submitter ⚠
- p.Glu264Lys Single submitter ⚠
- p.Glu324Gly Single submitter ⚠
- p.Glu410Asp Single submitter ⚠
- p.Glu434Asp Single submitter ⚠
- p.Glu464Gln Single submitter ⚠
- p.Glu48Gly Single submitter ⚠
- p.Glu558Gly Single submitter ⚠
- p.Glu644Asp Single submitter ⚠
- p.Glu692Asp Single submitter ⚠
- p.Glu942Lys Single submitter ⚠
- p.Glu942Val Single submitter ⚠
- p.Gly787Glu Single submitter ⚠
- p.Gly787Val Single submitter ⚠
- p.His1294Arg Single submitter ⚠
- p.His217Arg Single submitter ⚠
- p.Ile224Val Single submitter ⚠
- p.Ile420Val Single submitter ⚠
- p.Ile509Met Single submitter ⚠
- p.Ile772Val Single submitter ⚠
- p.Ile991Val Single submitter ⚠
- p.Leu100Phe Single submitter ⚠
- p.Leu1312Val Single submitter ⚠
- p.Leu362Phe Single submitter ⚠
- p.Leu385Met Single submitter ⚠
- p.Leu581Ile Single submitter ⚠
- p.Leu605Gln Single submitter ⚠
- p.Leu797Ile Single submitter ⚠
- p.Leu816Val Single submitter ⚠
- p.Leu833Ser Single submitter ⚠
- p.Lys1081Arg Single submitter ⚠
- p.Lys144Gln Single submitter ⚠
- p.Lys287Arg Single submitter ⚠
- p.Lys440Thr Single submitter ⚠
- p.Lys492Asn Single submitter ⚠
- p.Lys591Asn Single submitter ⚠
- p.Lys846Arg Single submitter ⚠
- p.Met1076Val Single submitter ⚠
- p.Met1177Val Single submitter ⚠
- p.Met235Ile Single submitter ⚠
- p.Met568Ile Single submitter ⚠
- p.Met568Thr Single submitter ⚠
- p.Met598Thr Single submitter ⚠
- p.Met918Leu Single submitter ⚠
- p.Met918Val Single submitter ⚠
- p.Phe1366Ser Single submitter ⚠
- p.Phe467Cys Single submitter ⚠
- p.Phe777Leu Single submitter ⚠
- p.Phe962Leu Single submitter ⚠
- p.Pro1030Ser Single submitter ⚠
- p.Pro1051Ser Single submitter ⚠
- p.Pro164Leu Single submitter ⚠
- p.Pro279Leu Single submitter ⚠
- p.Pro969Ser Single submitter ⚠
- p.Pro982Leu Single submitter ⚠
- p.Ser1056Arg Single submitter ⚠
- p.Ser230Pro Single submitter ⚠
- p.Ser30Pro Single submitter ⚠
- p.Ser408Cys Single submitter ⚠
- p.Ser42Pro Single submitter ⚠
- p.Ser449Phe Single submitter ⚠
- p.Ser585Leu Single submitter ⚠
- p.Ser717Ile Single submitter ⚠
- p.Ser748Pro Single submitter ⚠
- p.Ser753Cys Single submitter ⚠
- p.Ser809Arg Single submitter ⚠
- p.Ser809Asn Single submitter ⚠
- p.Ser919Pro Single submitter ⚠
- p.Thr1043Ile Single submitter ⚠
- p.Thr39Arg Single submitter ⚠
- p.Thr474Ile Single submitter ⚠
- p.Thr497Pro Single submitter ⚠
- p.Thr630Met Single submitter ⚠
- p.Thr908Pro Single submitter ⚠
- p.Thr961Ile Single submitter ⚠
- p.Thr97Ile Single submitter ⚠
- p.Thr980Ile Single submitter ⚠
- p.Trp881Arg Single submitter ⚠
- p.Tyr1058Cys Single submitter ⚠
- p.Val1079Leu Single submitter ⚠
- p.Val121Leu Single submitter ⚠
- p.Val1369Ile Single submitter ⚠
- p.Val251Met Single submitter ⚠
- p.Val997Ala Single submitter ⚠