CCND3 — 31 ClinVar variants
All ClinVar germline CCND3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
3 Benign · 28 Uncertain significance
Full CCND3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCND3 p.Ala131Thr Uncertain significance Single submitter
- CCND3 p.Ala154Ser Uncertain significance Single submitter
- CCND3 p.Ala204Thr Uncertain significance Single submitter
- CCND3 p.Ala249Thr Uncertain significance Single submitter
- CCND3 p.Ala269Thr Uncertain significance Single submitter
- CCND3 p.Arg10Pro Uncertain significance Single submitter
- CCND3 p.Arg174Gln Uncertain significance Single submitter
- CCND3 p.Arg271Gln Uncertain significance Single submitter
- CCND3 p.Arg271Leu Uncertain significance Single submitter
- CCND3 p.Cys91Tyr Uncertain significance Single submitter
- CCND3 p.Glu69Lys Uncertain significance Single submitter
- CCND3 p.His130Asn Uncertain significance Single submitter
- CCND3 p.His130Tyr Uncertain significance Single submitter
- CCND3 p.Ile164Val Uncertain significance Single submitter
- CCND3 p.Ile247Met Uncertain significance Single submitter
- CCND3 p.Leu85Met Uncertain significance Single submitter
- CCND3 p.Met82Val Uncertain significance Single submitter
- CCND3 p.Ser273Pro Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CCND3 p.Ala230Val Uncertain significance Single submitter
- CCND3 p.Ala258Val Uncertain significance Single submitter
- CCND3 p.Arg33Gly Uncertain significance Single submitter
- CCND3 p.Asp18Asn Uncertain significance Single submitter
- CCND3 p.Gln29Lys Uncertain significance Single submitter
- CCND3 p.Glu122Gly Uncertain significance Single submitter
- CCND3 p.Glu51Lys Uncertain significance Single submitter
- CCND3 p.Pro17Ser Uncertain significance Single submitter
- CCND3 p.Ser275Asn Uncertain significance Single submitter
- CCND3 p.Ser90Thr Uncertain significance Single submitter
All CCND3 variants
Benign 3
- c.-45-16836C>T Single submitter
- p.Asn83= Single submitter
- p.Leu228= Single submitter
Uncertain significance 28
- p.Ala131Thr Single submitter ⚠
- p.Ala154Ser Single submitter ⚠
- p.Ala204Thr Single submitter ⚠
- p.Ala230Val Single submitter ⚠
- p.Ala249Thr Single submitter ⚠
- p.Ala258Val Single submitter ⚠
- p.Ala269Thr Single submitter ⚠
- p.Arg10Pro Single submitter ⚠
- p.Arg174Gln Single submitter ⚠
- p.Arg271Gln Single submitter ⚠
- p.Arg271Leu Single submitter ⚠
- p.Arg33Gly Single submitter ⚠
- p.Asp18Asn Single submitter ⚠
- p.Cys91Tyr Single submitter ⚠
- p.Gln29Lys Single submitter ⚠
- p.Glu122Gly Single submitter ⚠
- p.Glu51Lys Single submitter ⚠
- p.Glu69Lys Single submitter ⚠
- p.His130Asn Single submitter ⚠
- p.His130Tyr Single submitter ⚠
- p.Ile164Val Single submitter ⚠
- p.Ile247Met Single submitter ⚠
- p.Leu85Met Single submitter ⚠
- p.Met82Val Single submitter ⚠
- p.Pro17Ser Single submitter ⚠
- p.Ser273Pro Single submitter ⚠
- p.Ser275Asn Single submitter ⚠
- p.Ser90Thr Single submitter ⚠