CCNE1 — 40 ClinVar variants
All ClinVar germline CCNE1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
5 Likely benign · 35 Uncertain significance
Full CCNE1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCNE1 p.Ala22Val Uncertain significance Single submitter
- CCNE1 p.Arg5Leu Uncertain significance Single submitter
- CCNE1 p.Arg85Gln Uncertain significance Single submitter
- CCNE1 p.Asn260Asp Uncertain significance Single submitter
- CCNE1 p.Asn65Ser Uncertain significance Single submitter
- CCNE1 p.Asp368Glu Uncertain significance Single submitter
- CCNE1 p.Asp43Glu Uncertain significance Single submitter
- CCNE1 p.Asp82Gly Uncertain significance Single submitter
- CCNE1 p.Asp83Gly Uncertain significance Single submitter
- CCNE1 p.Asp83His Uncertain significance Single submitter
- CCNE1 p.Gly406Arg Uncertain significance Single submitter
- CCNE1 p.Leu190Pro Uncertain significance Single submitter
- CCNE1 p.Lys402Arg Uncertain significance Single submitter
- CCNE1 p.Met234Val Uncertain significance Single submitter
- CCNE1 p.Met336Val Uncertain significance Single submitter
- CCNE1 p.Pro104Leu Uncertain significance Single submitter
- CCNE1 p.Pro42Gln Uncertain significance Single submitter
- CCNE1 p.Pro76Leu Uncertain significance Single submitter
- CCNE1 p.Pro88Arg Uncertain significance Single submitter
- CCNE1 p.Val107Ile Uncertain significance Single submitter
- CCNE1 p.Val37Leu Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CCNE1 p.Ala111Gly Uncertain significance Single submitter
- CCNE1 p.Ala178Val Uncertain significance Single submitter
- CCNE1 p.Arg13Trp Uncertain significance Single submitter
- CCNE1 p.Arg350Gly Uncertain significance Single submitter
- CCNE1 p.Arg5Cys Uncertain significance Single submitter
- CCNE1 p.Arg8Trp Uncertain significance Single submitter
- CCNE1 p.Ile324Met Uncertain significance Single submitter
- CCNE1 p.Ile360Val Uncertain significance Single submitter
- CCNE1 p.Leu227Arg Uncertain significance Single submitter
- CCNE1 p.Leu231Phe Uncertain significance Single submitter
- CCNE1 p.Phe38Leu Uncertain significance Single submitter
- CCNE1 p.Pro268Leu Uncertain significance Single submitter
- CCNE1 p.Pro78Thr Uncertain significance Single submitter
- CCNE1 p.Val35Met Uncertain significance Single submitter
All CCNE1 variants
Likely benign 5
- p.Gly400Ser Single submitter
- p.His263Tyr Single submitter
- p.Ile298Val Single submitter
- p.Met232Ile Single submitter
- p.Pro295Ser Single submitter
Uncertain significance 35
- p.Ala111Gly Single submitter ⚠
- p.Ala178Val Single submitter ⚠
- p.Ala22Val Single submitter ⚠
- p.Arg13Trp Single submitter ⚠
- p.Arg350Gly Single submitter ⚠
- p.Arg5Cys Single submitter ⚠
- p.Arg5Leu Single submitter ⚠
- p.Arg85Gln Single submitter ⚠
- p.Arg8Trp Single submitter ⚠
- p.Asn260Asp Single submitter ⚠
- p.Asn65Ser Single submitter ⚠
- p.Asp368Glu Single submitter ⚠
- p.Asp43Glu Single submitter ⚠
- p.Asp82Gly Single submitter ⚠
- p.Asp83Gly Single submitter ⚠
- p.Asp83His Single submitter ⚠
- p.Gly406Arg Single submitter ⚠
- p.Ile324Met Single submitter ⚠
- p.Ile360Val Single submitter ⚠
- p.Leu190Pro Single submitter ⚠
- p.Leu227Arg Single submitter ⚠
- p.Leu231Phe Single submitter ⚠
- p.Lys402Arg Single submitter ⚠
- p.Met234Val Single submitter ⚠
- p.Met336Val Single submitter ⚠
- p.Phe38Leu Single submitter ⚠
- p.Pro104Leu Single submitter ⚠
- p.Pro268Leu Single submitter ⚠
- p.Pro42Gln Single submitter ⚠
- p.Pro76Leu Single submitter ⚠
- p.Pro78Thr Single submitter ⚠
- p.Pro88Arg Single submitter ⚠
- p.Val107Ile Single submitter ⚠
- p.Val35Met Single submitter ⚠
- p.Val37Leu Single submitter ⚠