CCNG1 — 24 ClinVar variants
All ClinVar germline CCNG1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
24 Uncertain significance
Full CCNG1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
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CCNG1 p.Trp147Cys
Uncertain significance
Multiple submitters
hereditary breast ovarian cancer syndrome
- CCNG1 p.Ala118Thr Uncertain significance Single submitter
- CCNG1 p.Ala151Thr Uncertain significance Single submitter
- CCNG1 p.Arg275Gln Uncertain significance Single submitter
- CCNG1 p.Asn178Thr Uncertain significance Single submitter
- CCNG1 p.Cys226Ser Uncertain significance Single submitter
- CCNG1 p.Cys257Gly Uncertain significance Single submitter
- CCNG1 p.Gln228Arg Uncertain significance Single submitter
- CCNG1 p.Gln263Glu Uncertain significance Single submitter
- CCNG1 p.Glu22Lys Uncertain significance Single submitter
- CCNG1 p.Gly44Asp Uncertain significance Single submitter
- CCNG1 p.Leu117Met Uncertain significance Single submitter
- CCNG1 p.Leu51Arg Uncertain significance Single submitter
- CCNG1 p.Lys30Arg Uncertain significance Single submitter
- CCNG1 p.Thr130Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- CCNG1 p.Asp58Gly Uncertain significance Single submitter
- CCNG1 p.Glu143Gln Uncertain significance Single submitter
- CCNG1 p.Gly33Arg Uncertain significance Single submitter
- CCNG1 p.Gly44Ser Uncertain significance Single submitter
- CCNG1 p.Ile37Met Uncertain significance Single submitter
- CCNG1 p.Leu169Phe Uncertain significance Single submitter
- CCNG1 p.Leu205Phe Uncertain significance Single submitter
- CCNG1 p.Phe65Leu Uncertain significance Single submitter
- CCNG1 p.Tyr161Cys Uncertain significance Single submitter
All CCNG1 variants
Uncertain significance 24
- p.Trp147Cys Multiple submitters hereditary breast ovarian cancer syndrome ⚠
- p.Ala118Thr Single submitter ⚠
- p.Ala151Thr Single submitter ⚠
- p.Arg275Gln Single submitter ⚠
- p.Asn178Thr Single submitter ⚠
- p.Asp58Gly Single submitter ⚠
- p.Cys226Ser Single submitter ⚠
- p.Cys257Gly Single submitter ⚠
- p.Gln228Arg Single submitter ⚠
- p.Gln263Glu Single submitter ⚠
- p.Glu143Gln Single submitter ⚠
- p.Glu22Lys Single submitter ⚠
- p.Gly33Arg Single submitter ⚠
- p.Gly44Asp Single submitter ⚠
- p.Gly44Ser Single submitter ⚠
- p.Ile37Met Single submitter ⚠
- p.Leu117Met Single submitter ⚠
- p.Leu169Phe Single submitter ⚠
- p.Leu205Phe Single submitter ⚠
- p.Leu51Arg Single submitter ⚠
- p.Lys30Arg Single submitter ⚠
- p.Phe65Leu Single submitter ⚠
- p.Thr130Met Single submitter ⚠
- p.Tyr161Cys Single submitter ⚠