CCNG2 — 31 ClinVar variants
All ClinVar germline CCNG2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
4 Benign · 1 Likely benign · 26 Uncertain significance
Full CCNG2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCNG2 p.Arg127Gln Uncertain significance Single submitter
- CCNG2 p.Arg86Thr Uncertain significance Single submitter
- CCNG2 p.Asn333Ser Uncertain significance Single submitter
- CCNG2 p.Cys209Ser Uncertain significance Single submitter
- CCNG2 p.Cys251Arg Uncertain significance Single submitter
- CCNG2 p.Gln16Arg Uncertain significance Single submitter
- CCNG2 p.Glu222Gln Uncertain significance Single submitter
- CCNG2 p.Glu246Gln Uncertain significance Single submitter
- CCNG2 p.His12Asp Uncertain significance Single submitter
- CCNG2 p.His12Gln Uncertain significance Single submitter
- CCNG2 p.His97Tyr Uncertain significance Single submitter
- CCNG2 p.Leu227Val Uncertain significance Single submitter
- CCNG2 p.Leu252Pro Uncertain significance Single submitter
- CCNG2 p.Lys132Arg Uncertain significance Single submitter
- CCNG2 p.Met311Lys Uncertain significance Single submitter
- CCNG2 p.Met311Thr Uncertain significance Single submitter
- CCNG2 p.Thr167Ala Uncertain significance Single submitter
- CCNG2 p.Thr167Ser Uncertain significance Single submitter
- CCNG2 p.Val215Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CCNG2 p.Ala207Ser Uncertain significance Single submitter
- CCNG2 p.Arg111Gly Uncertain significance Single submitter
- CCNG2 p.Arg111Ile Uncertain significance Single submitter
- CCNG2 p.Arg275His Uncertain significance Single submitter
- CCNG2 p.Leu18Ile Uncertain significance Single submitter
- CCNG2 p.Met91Ile Uncertain significance Single submitter
- CCNG2 p.Ser181Arg Uncertain significance Single submitter
All CCNG2 variants
Benign 4
- p.Leu17= Multiple submitters
- p.Leu280= Multiple submitters
- p.Ser136= Multiple submitters
- p.Glu28Gly Single submitter
Likely benign 1
- p.Ile236Val Single submitter
Uncertain significance 26
- p.Ala207Ser Single submitter ⚠
- p.Arg111Gly Single submitter ⚠
- p.Arg111Ile Single submitter ⚠
- p.Arg127Gln Single submitter ⚠
- p.Arg275His Single submitter ⚠
- p.Arg86Thr Single submitter ⚠
- p.Asn333Ser Single submitter ⚠
- p.Cys209Ser Single submitter ⚠
- p.Cys251Arg Single submitter ⚠
- p.Gln16Arg Single submitter ⚠
- p.Glu222Gln Single submitter ⚠
- p.Glu246Gln Single submitter ⚠
- p.His12Asp Single submitter ⚠
- p.His12Gln Single submitter ⚠
- p.His97Tyr Single submitter ⚠
- p.Leu18Ile Single submitter ⚠
- p.Leu227Val Single submitter ⚠
- p.Leu252Pro Single submitter ⚠
- p.Lys132Arg Single submitter ⚠
- p.Met311Lys Single submitter ⚠
- p.Met311Thr Single submitter ⚠
- p.Met91Ile Single submitter ⚠
- p.Ser181Arg Single submitter ⚠
- p.Thr167Ala Single submitter ⚠
- p.Thr167Ser Single submitter ⚠
- p.Val215Leu Single submitter ⚠