CCNH — 46 ClinVar variants
All ClinVar germline CCNH variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
3 Benign · 1 Likely benign · 42 Uncertain significance
Full CCNH gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCNH p.Ala26Thr Uncertain significance Single submitter
- CCNH p.Arg279Gln Uncertain significance Single submitter
- CCNH p.Asn162Ser Uncertain significance Single submitter
- CCNH p.Asn37Ser Uncertain significance Single submitter
- CCNH p.Asp116Ala Uncertain significance Single submitter
- CCNH p.Asp173Asn Uncertain significance Single submitter
- CCNH p.Glu313Lys Uncertain significance Single submitter
- CCNH p.His309Arg Uncertain significance Single submitter
- CCNH p.Leu134Arg Uncertain significance Single submitter
- CCNH p.Leu287Val Uncertain significance Single submitter
- CCNH p.Lys114Thr Uncertain significance Single submitter
- CCNH p.Lys276Met Uncertain significance Single submitter
- CCNH p.Met85Thr Uncertain significance Single submitter
- CCNH p.Phe125Cys Uncertain significance Single submitter
- CCNH p.Ser254Thr Uncertain significance Single submitter
- CCNH p.Ser69Leu Uncertain significance Single submitter
- CCNH p.Tyr146Cys Uncertain significance Single submitter
- CCNH p.Tyr178Cys Uncertain significance Single submitter
- CCNH p.Tyr204Cys Uncertain significance Single submitter
- CCNH p.Tyr60Phe Uncertain significance Single submitter
- CCNH p.Val120Ile Uncertain significance Single submitter
- CCNH p.Val303Ile Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- CCNH p.Ala109Thr Uncertain significance Single submitter
- CCNH p.Arg28Cys Uncertain significance Single submitter
- CCNH p.Asn128Lys Uncertain significance Single submitter
- CCNH p.Asp250His Uncertain significance Single submitter
- CCNH p.Cys244Trp Uncertain significance Single submitter
- CCNH p.Gly38Arg Uncertain significance Single submitter
- CCNH p.His10Arg Uncertain significance Single submitter
- CCNH p.Leu22Arg Uncertain significance Single submitter
- CCNH p.Leu238Pro Uncertain significance Single submitter
- CCNH p.Leu248Ser Uncertain significance Single submitter
- CCNH p.Lys274Glu Uncertain significance Single submitter
- CCNH p.Pro42Leu Uncertain significance Single submitter
- CCNH p.Ser219Cys Uncertain significance Single submitter
- CCNH p.Thr107Ala Uncertain significance Single submitter
- CCNH p.Thr12Ala Uncertain significance Single submitter
- CCNH p.Thr201Met Uncertain significance Single submitter
- CCNH p.Tyr178Ser Uncertain significance Single submitter
- CCNH p.Tyr204Asn Uncertain significance Single submitter
- CCNH p.Val120Leu Uncertain significance Single submitter
- CCNH p.Val259Gly Uncertain significance Single submitter
All CCNH variants
Benign 3
- p.Arg28Leu Single submitter
- p.Lys138Arg Single submitter
- p.Met54Val Single submitter
Likely benign 1
- p.Phe87= Multiple submitters
Uncertain significance 42
- p.Ala109Thr Single submitter ⚠
- p.Ala26Thr Single submitter ⚠
- p.Arg279Gln Single submitter ⚠
- p.Arg28Cys Single submitter ⚠
- p.Asn128Lys Single submitter ⚠
- p.Asn162Ser Single submitter ⚠
- p.Asn37Ser Single submitter ⚠
- p.Asp116Ala Single submitter ⚠
- p.Asp173Asn Single submitter ⚠
- p.Asp250His Single submitter ⚠
- p.Cys244Trp Single submitter ⚠
- p.Glu313Lys Single submitter ⚠
- p.Gly38Arg Single submitter ⚠
- p.His10Arg Single submitter ⚠
- p.His309Arg Single submitter ⚠
- p.Leu134Arg Single submitter ⚠
- p.Leu22Arg Single submitter ⚠
- p.Leu238Pro Single submitter ⚠
- p.Leu248Ser Single submitter ⚠
- p.Leu287Val Single submitter ⚠
- p.Lys114Thr Single submitter ⚠
- p.Lys274Glu Single submitter ⚠
- p.Lys276Met Single submitter ⚠
- p.Met85Thr Single submitter ⚠
- p.Phe125Cys Single submitter ⚠
- p.Pro42Leu Single submitter ⚠
- p.Ser219Cys Single submitter ⚠
- p.Ser254Thr Single submitter ⚠
- p.Ser69Leu Single submitter ⚠
- p.Thr107Ala Single submitter ⚠
- p.Thr12Ala Single submitter ⚠
- p.Thr201Met Single submitter ⚠
- p.Tyr146Cys Single submitter ⚠
- p.Tyr178Cys Single submitter ⚠
- p.Tyr178Ser Single submitter ⚠
- p.Tyr204Asn Single submitter ⚠
- p.Tyr204Cys Single submitter ⚠
- p.Tyr60Phe Single submitter ⚠
- p.Val120Ile Single submitter ⚠
- p.Val120Leu Single submitter ⚠
- p.Val259Gly Single submitter ⚠
- p.Val303Ile Single submitter ⚠