CCNI2 — 61 ClinVar variants
All ClinVar germline CCNI2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
3 Likely benign · 58 Uncertain significance
Full CCNI2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCNI2 p.Arg55Ser Uncertain significance Single submitter
- CCNI2 p.Arg77Gly Uncertain significance Single submitter
- CCNI2 p.Arg79Gly Uncertain significance Single submitter
- CCNI2 p.Asp116Asn Uncertain significance Single submitter
- CCNI2 p.Asp118Glu Uncertain significance Single submitter
- CCNI2 p.Asp226Tyr Uncertain significance Single submitter
- CCNI2 p.Asp90Glu Uncertain significance Single submitter
- CCNI2 p.Cys343Arg Uncertain significance Single submitter
- CCNI2 p.Gln10His Uncertain significance Single submitter
- CCNI2 p.Glu151Lys Uncertain significance Single submitter
- CCNI2 p.Glu209Asp Uncertain significance Single submitter
- CCNI2 p.Glu272Lys Uncertain significance Single submitter
- CCNI2 p.Glu31Gly Uncertain significance Single submitter
- CCNI2 p.Gly27Ser Uncertain significance Single submitter
- CCNI2 p.Gly337Asp Uncertain significance Single submitter
- CCNI2 p.Gly36Asp Uncertain significance Single submitter
- CCNI2 p.Gly44Glu Uncertain significance Single submitter
- CCNI2 p.Gly86Arg Uncertain significance Single submitter
- CCNI2 p.His222Tyr Uncertain significance Single submitter
- CCNI2 p.His269Asn Uncertain significance Single submitter
- CCNI2 p.Leu247Pro Uncertain significance Single submitter
- CCNI2 p.Lys141Arg Uncertain significance Single submitter
- CCNI2 p.Lys205Asn Uncertain significance Single submitter
- CCNI2 p.Met235Ile Uncertain significance Single submitter
- CCNI2 p.Phe364Ser Uncertain significance Single submitter
- CCNI2 p.Pro103Arg Uncertain significance Single submitter
- CCNI2 p.Pro103Ser Uncertain significance Single submitter
- CCNI2 p.Pro110Leu Uncertain significance Single submitter
- CCNI2 p.Pro142Arg Uncertain significance Single submitter
- CCNI2 p.Pro57Leu Uncertain significance Single submitter
- CCNI2 p.Pro8Leu Uncertain significance Single submitter
- CCNI2 p.Ser13Gly Uncertain significance Single submitter
- CCNI2 p.Ser342Asn Uncertain significance Single submitter
- CCNI2 p.Ser3Leu Uncertain significance Single submitter
- CCNI2 p.Thr306Pro Uncertain significance Single submitter
- CCNI2 p.Tyr227Cys Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- CCNI2 p.Ala2Val Uncertain significance Single submitter
- CCNI2 p.Arg108Cys Uncertain significance Single submitter
- CCNI2 p.Arg159Trp Uncertain significance Single submitter
- CCNI2 p.Asp118Val Uncertain significance Single submitter
- CCNI2 p.Glu317Gly Uncertain significance Single submitter
- CCNI2 p.Ile177Val Uncertain significance Single submitter
- CCNI2 p.Leu182Arg Uncertain significance Single submitter
- CCNI2 p.Leu243Val Uncertain significance Single submitter
- CCNI2 p.Leu30Met Uncertain significance Single submitter
- CCNI2 p.Lys303Asn Uncertain significance Single submitter
- CCNI2 p.Phe166Leu Uncertain significance Single submitter
- CCNI2 p.Pro252Leu Uncertain significance Single submitter
- CCNI2 p.Pro268Thr Uncertain significance Single submitter
- CCNI2 p.Pro326Leu Uncertain significance Single submitter
- CCNI2 p.Ser359Phe Uncertain significance Single submitter
- CCNI2 p.Thr251Met Uncertain significance Single submitter
- CCNI2 p.Thr257Ile Uncertain significance Single submitter
- CCNI2 p.Thr82Met Uncertain significance Single submitter
- CCNI2 p.Trp267Arg Uncertain significance Single submitter
- CCNI2 p.Trp323Arg Uncertain significance Single submitter
- CCNI2 p.Tyr223Cys Uncertain significance Single submitter
- CCNI2 p.Val74Phe Uncertain significance Single submitter
All CCNI2 variants
Likely benign 3
- p.Ala89Thr Single submitter
- p.Pro47Ser Single submitter
- p.Thr251= Single submitter
Uncertain significance 58
- p.Ala2Val Single submitter ⚠
- p.Arg108Cys Single submitter ⚠
- p.Arg159Trp Single submitter ⚠
- p.Arg55Ser Single submitter ⚠
- p.Arg77Gly Single submitter ⚠
- p.Arg79Gly Single submitter ⚠
- p.Asp116Asn Single submitter ⚠
- p.Asp118Glu Single submitter ⚠
- p.Asp118Val Single submitter ⚠
- p.Asp226Tyr Single submitter ⚠
- p.Asp90Glu Single submitter ⚠
- p.Cys343Arg Single submitter ⚠
- p.Gln10His Single submitter ⚠
- p.Glu151Lys Single submitter ⚠
- p.Glu209Asp Single submitter ⚠
- p.Glu272Lys Single submitter ⚠
- p.Glu317Gly Single submitter ⚠
- p.Glu31Gly Single submitter ⚠
- p.Gly27Ser Single submitter ⚠
- p.Gly337Asp Single submitter ⚠
- p.Gly36Asp Single submitter ⚠
- p.Gly44Glu Single submitter ⚠
- p.Gly86Arg Single submitter ⚠
- p.His222Tyr Single submitter ⚠
- p.His269Asn Single submitter ⚠
- p.Ile177Val Single submitter ⚠
- p.Leu182Arg Single submitter ⚠
- p.Leu243Val Single submitter ⚠
- p.Leu247Pro Single submitter ⚠
- p.Leu30Met Single submitter ⚠
- p.Lys141Arg Single submitter ⚠
- p.Lys205Asn Single submitter ⚠
- p.Lys303Asn Single submitter ⚠
- p.Met235Ile Single submitter ⚠
- p.Phe166Leu Single submitter ⚠
- p.Phe364Ser Single submitter ⚠
- p.Pro103Arg Single submitter ⚠
- p.Pro103Ser Single submitter ⚠
- p.Pro110Leu Single submitter ⚠
- p.Pro142Arg Single submitter ⚠
- p.Pro252Leu Single submitter ⚠
- p.Pro268Thr Single submitter ⚠
- p.Pro326Leu Single submitter ⚠
- p.Pro57Leu Single submitter ⚠
- p.Pro8Leu Single submitter ⚠
- p.Ser13Gly Single submitter ⚠
- p.Ser342Asn Single submitter ⚠
- p.Ser359Phe Single submitter ⚠
- p.Ser3Leu Single submitter ⚠
- p.Thr251Met Single submitter ⚠
- p.Thr257Ile Single submitter ⚠
- p.Thr306Pro Single submitter ⚠
- p.Thr82Met Single submitter ⚠
- p.Trp267Arg Single submitter ⚠
- p.Trp323Arg Single submitter ⚠
- p.Tyr223Cys Single submitter ⚠
- p.Tyr227Cys Single submitter ⚠
- p.Val74Phe Single submitter ⚠