CCNL1 — 53 ClinVar variants
All ClinVar germline CCNL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
2 Likely benign · 51 Uncertain significance
Full CCNL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCNL1 p.Ala13Ser Uncertain significance Single submitter
- CCNL1 p.Ala13Thr Uncertain significance Single submitter
- CCNL1 p.Ala22Thr Uncertain significance Single submitter
- CCNL1 p.Ala248Ser Uncertain significance Single submitter
- CCNL1 p.Ala348Thr Uncertain significance Single submitter
- CCNL1 p.Ala392Pro Uncertain significance Single submitter
- CCNL1 p.Arg255Thr Uncertain significance Single submitter
- CCNL1 p.Arg396Gly Uncertain significance Single submitter
- CCNL1 p.Arg479Gln Uncertain significance Single submitter
- CCNL1 p.Arg479Trp Uncertain significance Single submitter
- CCNL1 p.Arg525Lys Uncertain significance Single submitter
- CCNL1 p.Arg526His Uncertain significance Single submitter
- CCNL1 p.Asn235Ser Uncertain significance Single submitter
- CCNL1 p.Asn388His Uncertain significance Single submitter
- CCNL1 p.Asp480Tyr Uncertain significance Single submitter
- CCNL1 p.Asp497Gly Uncertain significance Single submitter
- CCNL1 p.Gln71Glu Uncertain significance Single submitter
- CCNL1 p.Glu88Lys Uncertain significance Single submitter
- CCNL1 p.Gly38Arg Uncertain significance Single submitter
- CCNL1 p.Gly4Ala Uncertain significance Single submitter
- CCNL1 p.His406Arg Uncertain significance Single submitter
- CCNL1 p.His481Tyr Uncertain significance Single submitter
- CCNL1 p.His521Arg Uncertain significance Single submitter
- CCNL1 p.Ile146Val Uncertain significance Single submitter
- CCNL1 p.Ile250Thr Uncertain significance Single submitter
- CCNL1 p.Ile278Val Uncertain significance Single submitter
- CCNL1 p.Leu209Val Uncertain significance Single submitter
- CCNL1 p.Pro66Thr Uncertain significance Single submitter
- CCNL1 p.Ser355Pro Uncertain significance Single submitter
- CCNL1 p.Ser459Arg Uncertain significance Single submitter
- CCNL1 p.Ser460Thr Uncertain significance Single submitter
- CCNL1 p.Ser519Leu Uncertain significance Single submitter
- CCNL1 p.Thr164Ile Uncertain significance Single submitter
- CCNL1 p.Thr263Ala Uncertain significance Single submitter
- CCNL1 p.Thr263Ile Uncertain significance Single submitter
- CCNL1 p.Thr32Ala Uncertain significance Single submitter
- CCNL1 p.Thr453Asn Uncertain significance Single submitter
- CCNL1 p.Tyr296Cys Uncertain significance Single submitter
- CCNL1 p.Val379Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CCNL1 p.Arg416Gln Uncertain significance Single submitter
- CCNL1 p.Arg63Thr Uncertain significance Single submitter
- CCNL1 p.Asn151Lys Uncertain significance Single submitter
- CCNL1 p.Asn217Asp Uncertain significance Single submitter
- CCNL1 p.Asp81Ala Uncertain significance Single submitter
- CCNL1 p.Leu159Phe Uncertain significance Single submitter
- CCNL1 p.Ser395Leu Uncertain significance Single submitter
- CCNL1 p.Ser474Cys Uncertain significance Single submitter
- CCNL1 p.Thr32Met Uncertain significance Single submitter
- CCNL1 p.Thr37Lys Uncertain significance Single submitter
All CCNL1 variants
Likely benign 2
- p.Arg498= Single submitter
- p.Ile354Val Single submitter
Uncertain significance 51
- p.Ala13Ser Single submitter ⚠
- p.Ala13Thr Single submitter ⚠
- p.Ala22Thr Single submitter ⚠
- p.Ala248Ser Single submitter ⚠
- p.Ala348Thr Single submitter ⚠
- p.Ala392Pro Single submitter ⚠
- p.Arg255Thr Single submitter ⚠
- p.Arg396Gly Single submitter ⚠
- p.Arg416Gln Single submitter ⚠
- p.Arg479Gln Single submitter ⚠
- p.Arg479Trp Single submitter ⚠
- p.Arg525Lys Single submitter ⚠
- p.Arg526His Single submitter ⚠
- p.Arg63Thr Single submitter ⚠
- p.Asn151Lys Single submitter ⚠
- p.Asn217Asp Single submitter ⚠
- p.Asn235Ser Single submitter ⚠
- p.Asn388His Single submitter ⚠
- p.Asp480Tyr Single submitter ⚠
- p.Asp497Gly Single submitter ⚠
- p.Asp81Ala Single submitter ⚠
- p.Gln71Glu Single submitter ⚠
- p.Glu88Lys Single submitter ⚠
- p.Gly38Arg Single submitter ⚠
- p.Gly4Ala Single submitter ⚠
- p.His406Arg Single submitter ⚠
- p.His481Tyr Single submitter ⚠
- p.His521Arg Single submitter ⚠
- p.Ile146Val Single submitter ⚠
- p.Ile250Thr Single submitter ⚠
- p.Ile278Val Single submitter ⚠
- p.Leu159Phe Single submitter ⚠
- p.Leu209Val Single submitter ⚠
- p.Pro165fs Single submitter
- p.Pro66Thr Single submitter ⚠
- p.Ser355Pro Single submitter ⚠
- p.Ser395Leu Single submitter ⚠
- p.Ser459Arg Single submitter ⚠
- p.Ser460Thr Single submitter ⚠
- p.Ser474Cys Single submitter ⚠
- p.Ser519Leu Single submitter ⚠
- p.Thr164Ile Single submitter ⚠
- p.Thr263Ala Single submitter ⚠
- p.Thr263Ile Single submitter ⚠
- p.Thr32Ala Single submitter ⚠
- p.Thr32Met Single submitter ⚠
- p.Thr37Lys Single submitter ⚠
- p.Thr453Asn Single submitter ⚠
- p.Tyr251Cys Single submitter
- p.Tyr296Cys Single submitter ⚠
- p.Val379Ile Single submitter ⚠