CCNL2 — 107 ClinVar variants
All ClinVar germline CCNL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 99 flagged for review →
1 Benign · 9 Likely benign · 97 Uncertain significance
Full CCNL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 99
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCNL2 p.Ala22Ser Uncertain significance Single submitter
- CCNL2 p.Ala332Val Uncertain significance Single submitter
- CCNL2 p.Ala362Gly Uncertain significance Single submitter
- CCNL2 p.Ala399Val Uncertain significance Single submitter
- CCNL2 p.Ala436Thr Uncertain significance Single submitter
- CCNL2 p.Arg228His Uncertain significance Single submitter
- CCNL2 p.Arg313Gln Uncertain significance Single submitter
- CCNL2 p.Arg357Gly Uncertain significance Single submitter
- CCNL2 p.Arg403Lys Uncertain significance Single submitter
- CCNL2 p.Arg434Pro Uncertain significance Single submitter
- CCNL2 p.Arg93Cys Uncertain significance Single submitter
- CCNL2 p.Asn258Lys Uncertain significance Single submitter
- CCNL2 p.Asn258Ser Uncertain significance Single submitter
- CCNL2 p.Asp166Asn Uncertain significance Single submitter
- CCNL2 p.Gln321Arg Uncertain significance Single submitter
- CCNL2 p.Gln493Glu Uncertain significance Single submitter
- CCNL2 p.Glu306Ala Uncertain significance Single submitter
- CCNL2 p.Glu306Lys Uncertain significance Single submitter
- CCNL2 p.Glu337Lys Uncertain significance Single submitter
- CCNL2 p.Glu379Gln Uncertain significance Single submitter
- CCNL2 p.Gly12Ala Uncertain significance Single submitter
- CCNL2 p.Gly342Ser Uncertain significance Single submitter
- CCNL2 p.Gly342Val Uncertain significance Single submitter
- CCNL2 p.Gly377Glu Uncertain significance Single submitter
- CCNL2 p.His122Arg Uncertain significance Single submitter
- CCNL2 p.His488Asn Uncertain significance Single submitter
- CCNL2 p.His488Tyr Uncertain significance Single submitter
- CCNL2 p.Ile276Thr Uncertain significance Single submitter
- CCNL2 p.Ile305Met Uncertain significance Single submitter
- CCNL2 p.Leu323Pro Uncertain significance Single submitter
- CCNL2 p.Leu359Pro Uncertain significance Single submitter
- CCNL2 p.Leu36Val Uncertain significance Single submitter
- CCNL2 p.Leu53Phe Uncertain significance Single submitter
- CCNL2 p.Lys366Arg Uncertain significance Single submitter
- CCNL2 p.Lys453Arg Uncertain significance Single submitter
- CCNL2 p.Lys482Arg Uncertain significance Single submitter
- CCNL2 p.Phe266Leu Uncertain significance Single submitter
- CCNL2 p.Pro333Arg Uncertain significance Single submitter
- CCNL2 p.Pro347Thr Uncertain significance Single submitter
- CCNL2 p.Pro375Ser Uncertain significance Single submitter
- CCNL2 p.Pro433Ala Uncertain significance Single submitter
- CCNL2 p.Ser114Phe Uncertain significance Single submitter
- CCNL2 p.Ser13Ala Uncertain significance Single submitter
- CCNL2 p.Ser487Arg Uncertain significance Single submitter
- CCNL2 p.Thr320Ile Uncertain significance Single submitter
- CCNL2 p.Thr504Ala Uncertain significance Single submitter
- CCNL2 p.Thr71Ala Uncertain significance Single submitter
Predictors split 52
The independent predictors disagree with each other — read with care.
- CCNL2 p.Ala10Thr Uncertain significance Single submitter
- CCNL2 p.Ala18Thr Uncertain significance Single submitter
- CCNL2 p.Ala19Ser Uncertain significance Single submitter
- CCNL2 p.Ala310Val Uncertain significance Single submitter
- CCNL2 p.Ala6Val Uncertain significance Single submitter
- CCNL2 p.Ala7Glu Uncertain significance Single submitter
- CCNL2 p.Ala8Pro Uncertain significance Single submitter
- CCNL2 p.Arg182Gln Uncertain significance Single submitter
- CCNL2 p.Arg286Gln Uncertain significance Single submitter
- CCNL2 p.Arg313Trp Uncertain significance Single submitter
- CCNL2 p.Arg381Gln Uncertain significance Single submitter
- CCNL2 p.Arg383Gln Uncertain significance Single submitter
- CCNL2 p.Arg385Gln Uncertain significance Single submitter
- CCNL2 p.Arg387His Uncertain significance Single submitter
- CCNL2 p.Arg403Met Uncertain significance Single submitter
- CCNL2 p.Arg420Cys Uncertain significance Single submitter
- CCNL2 p.Arg447Trp Uncertain significance Single submitter
- CCNL2 p.Arg464Gln Uncertain significance Single submitter
- CCNL2 p.Arg468His Uncertain significance Single submitter
- CCNL2 p.Arg470Gln Uncertain significance Single submitter
- CCNL2 p.Arg474Gln Uncertain significance Single submitter
- CCNL2 p.Arg474Trp Uncertain significance Single submitter
- CCNL2 p.Arg476Gln Uncertain significance Single submitter
- CCNL2 p.Arg476Trp Uncertain significance Single submitter
- CCNL2 p.Arg494Gln Uncertain significance Single submitter
- CCNL2 p.Arg497Cys Uncertain significance Single submitter
- CCNL2 p.Arg503His Uncertain significance Single submitter
- CCNL2 p.Arg506His Likely benign Single submitter
- CCNL2 p.Arg507Cys Uncertain significance Single submitter
- CCNL2 p.Arg517Lys Uncertain significance Single submitter
- CCNL2 p.Arg517Thr Uncertain significance Single submitter
- CCNL2 p.Arg519Gln Uncertain significance Single submitter
- CCNL2 p.Glu121Gln Uncertain significance Single submitter
- CCNL2 p.Glu299Val Uncertain significance Single submitter
- CCNL2 p.Gly26Trp Uncertain significance Single submitter
- CCNL2 p.Gly44Arg Uncertain significance Single submitter
- CCNL2 p.Gly81Ala Uncertain significance Single submitter
- CCNL2 p.His129Pro Uncertain significance Single submitter
- CCNL2 p.His261Arg Uncertain significance Single submitter
- CCNL2 p.Leu252Met Uncertain significance Single submitter
- CCNL2 p.Leu41Gln Uncertain significance Single submitter
- CCNL2 p.Leu77Phe Uncertain significance Single submitter
- CCNL2 p.Lys113Asn Uncertain significance Single submitter
- CCNL2 p.Lys279Thr Uncertain significance Single submitter
- CCNL2 p.Ser25Phe Uncertain significance Single submitter
- CCNL2 p.Ser392Leu Uncertain significance Single submitter
- CCNL2 p.Ser463Asn Uncertain significance Single submitter
- CCNL2 p.Ser500Leu Uncertain significance Single submitter
- CCNL2 p.Val161Met Uncertain significance Single submitter
- CCNL2 p.Val35Leu Uncertain significance Single submitter
- CCNL2 p.Val371Met Uncertain significance Single submitter
-
CCNL2 p.Ser25Cys
Likely benign
No assertion criteria
CCNL2-related disorder
All CCNL2 variants
Benign 1
- c.*4G>A No assertion criteria CCNL2-related disorder
Likely benign 9
- p.Ala477Val Single submitter
- p.Arg506His Single submitter ⚠
- c.473+10_473+13del No assertion criteria CCNL2-related disorder
- c.474-6del No assertion criteria CCNL2-related disorder
- p.Arg40= No assertion criteria CCNL2-related disorder
- p.Ser25Cys No assertion criteria CCNL2-related disorder ⚠
- p.Ser327= No assertion criteria CCNL2-related disorder
- p.Ser330= No assertion criteria CCNL2-related disorder
- p.Ser67= No assertion criteria CCNL2-related disorder
Uncertain significance 97
- p.Ala10Thr Single submitter ⚠
- p.Ala18Thr Single submitter ⚠
- p.Ala19Ser Single submitter ⚠
- p.Ala22Ser Single submitter ⚠
- p.Ala310Val Single submitter ⚠
- p.Ala332Val Single submitter ⚠
- p.Ala362Gly Single submitter ⚠
- p.Ala399Val Single submitter ⚠
- p.Ala436Thr Single submitter ⚠
- p.Ala6Val Single submitter ⚠
- p.Ala7Glu Single submitter ⚠
- p.Ala8Pro Single submitter ⚠
- p.Arg182Gln Single submitter ⚠
- p.Arg228His Single submitter ⚠
- p.Arg286Gln Single submitter ⚠
- p.Arg313Gln Single submitter ⚠
- p.Arg313Trp Single submitter ⚠
- p.Arg357Gly Single submitter ⚠
- p.Arg381Gln Single submitter ⚠
- p.Arg383Gln Single submitter ⚠
- p.Arg385Gln Single submitter ⚠
- p.Arg387His Single submitter ⚠
- p.Arg403Lys Single submitter ⚠
- p.Arg403Met Single submitter ⚠
- p.Arg420Cys Single submitter ⚠
- p.Arg434Pro Single submitter ⚠
- p.Arg447Trp Single submitter ⚠
- p.Arg464Gln Single submitter ⚠
- p.Arg468His Single submitter ⚠
- p.Arg470Gln Single submitter ⚠
- p.Arg474Gln Single submitter ⚠
- p.Arg474Trp Single submitter ⚠
- p.Arg476Gln Single submitter ⚠
- p.Arg476Trp Single submitter ⚠
- p.Arg494Gln Single submitter ⚠
- p.Arg497Cys Single submitter ⚠
- p.Arg503His Single submitter ⚠
- p.Arg507Cys Single submitter ⚠
- p.Arg517Lys Single submitter ⚠
- p.Arg517Thr Single submitter ⚠
- p.Arg519Gln Single submitter ⚠
- p.Arg93Cys Single submitter ⚠
- p.Asn258Lys Single submitter ⚠
- p.Asn258Ser Single submitter ⚠
- p.Asp166Asn Single submitter ⚠
- p.Gln321Arg Single submitter ⚠
- p.Gln493Glu Single submitter ⚠
- p.Glu121Gln Single submitter ⚠
- p.Glu299Val Single submitter ⚠
- p.Glu306Ala Single submitter ⚠
- p.Glu306Lys Single submitter ⚠
- p.Glu337Lys Single submitter ⚠
- p.Glu379Gln Single submitter ⚠
- p.Gly12Ala Single submitter ⚠
- p.Gly26Trp Single submitter ⚠
- p.Gly342Ser Single submitter ⚠
- p.Gly342Val Single submitter ⚠
- p.Gly377Glu Single submitter ⚠
- p.Gly44Arg Single submitter ⚠
- p.Gly81Ala Single submitter ⚠
- p.His122Arg Single submitter ⚠
- p.His129Pro Single submitter ⚠
- p.His261Arg Single submitter ⚠
- p.His488Asn Single submitter ⚠
- p.His488Tyr Single submitter ⚠
- p.Ile276Thr Single submitter ⚠
- p.Ile305Met Single submitter ⚠
- p.Leu252Met Single submitter ⚠
- p.Leu323Pro Single submitter ⚠
- p.Leu359Pro Single submitter ⚠
- p.Leu36Val Single submitter ⚠
- p.Leu41Gln Single submitter ⚠
- p.Leu53Phe Single submitter ⚠
- p.Leu77Phe Single submitter ⚠
- p.Lys113Asn Single submitter ⚠
- p.Lys279Thr Single submitter ⚠
- p.Lys366Arg Single submitter ⚠
- p.Lys453Arg Single submitter ⚠
- p.Lys482Arg Single submitter ⚠
- p.Phe266Leu Single submitter ⚠
- p.Pro333Arg Single submitter ⚠
- p.Pro347Thr Single submitter ⚠
- p.Pro375Ser Single submitter ⚠
- p.Pro433Ala Single submitter ⚠
- p.Ser114Phe Single submitter ⚠
- p.Ser13Ala Single submitter ⚠
- p.Ser25Phe Single submitter ⚠
- p.Ser392Leu Single submitter ⚠
- p.Ser463Asn Single submitter ⚠
- p.Ser487Arg Single submitter ⚠
- p.Ser500Leu Single submitter ⚠
- p.Thr320Ile Single submitter ⚠
- p.Thr504Ala Single submitter ⚠
- p.Thr71Ala Single submitter ⚠
- p.Val161Met Single submitter ⚠
- p.Val35Leu Single submitter ⚠
- p.Val371Met Single submitter ⚠