CCNT1 — 71 ClinVar variants
All ClinVar germline CCNT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
5 Likely benign · 66 Uncertain significance
Full CCNT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCNT1 p.Ala356Glu Uncertain significance Single submitter
- CCNT1 p.Ala394Thr Uncertain significance Single submitter
- CCNT1 p.Ala394Val Uncertain significance Single submitter
- CCNT1 p.Ala489Val Uncertain significance Single submitter
- CCNT1 p.Arg25Gly Uncertain significance Single submitter
- CCNT1 p.Arg333Cys Uncertain significance Single submitter
- CCNT1 p.Arg333His Uncertain significance Single submitter
- CCNT1 p.Arg393His Uncertain significance Single submitter
- CCNT1 p.Arg449Trp Uncertain significance Single submitter
- CCNT1 p.Arg463Lys Uncertain significance Single submitter
- CCNT1 p.Arg504Gln Uncertain significance Single submitter
- CCNT1 p.Arg633His Uncertain significance Single submitter
- CCNT1 p.Arg694Gln Uncertain significance Single submitter
- CCNT1 p.Arg709Trp Uncertain significance Single submitter
- CCNT1 p.Asn494Asp Uncertain significance Single submitter
- CCNT1 p.Asn494Ser Uncertain significance Single submitter
- CCNT1 p.Asn522His Uncertain significance Single submitter
- CCNT1 p.Asp367Asn Uncertain significance Single submitter
- CCNT1 p.Asp456Gly Uncertain significance Single submitter
- CCNT1 p.Asp470Gly Uncertain significance Single submitter
- CCNT1 p.Cys630Tyr Uncertain significance Single submitter
- CCNT1 p.Gln281His Uncertain significance Single submitter
- CCNT1 p.Gln289Pro Uncertain significance Single submitter
- CCNT1 p.Gln532His Uncertain significance Single submitter
- CCNT1 p.Glu442Val Uncertain significance Single submitter
- CCNT1 p.Glu508Val Uncertain significance Single submitter
- CCNT1 p.Gly273Glu Uncertain significance Single submitter
- CCNT1 p.Gly543Ser Uncertain significance Single submitter
- CCNT1 p.Gly582Arg Uncertain significance Single submitter
- CCNT1 p.His362Asp Uncertain significance Single submitter
- CCNT1 p.His517Tyr Uncertain significance Single submitter
- CCNT1 p.His616Arg Uncertain significance Single submitter
- CCNT1 p.His665Pro Uncertain significance Single submitter
- CCNT1 p.Ile150Phe Uncertain significance Single submitter
- CCNT1 p.Ile436Thr Uncertain significance Single submitter
- CCNT1 p.Leu133Val Uncertain significance Single submitter
- CCNT1 p.Leu90Val Uncertain significance Single submitter
- CCNT1 p.Lys457Arg Uncertain significance Single submitter
- CCNT1 p.Met328Leu Uncertain significance Single submitter
- CCNT1 p.Met439Thr Uncertain significance Single submitter
- CCNT1 p.Met613Ile Uncertain significance Single submitter
- CCNT1 p.Pro330Ala Uncertain significance Single submitter
- CCNT1 p.Pro383Ala Uncertain significance Single submitter
- CCNT1 p.Pro477Leu Uncertain significance Single submitter
- CCNT1 p.Pro712Arg Uncertain significance Single submitter
- CCNT1 p.Ser352Gly Uncertain significance Single submitter
- CCNT1 p.Ser36Pro Uncertain significance Single submitter
- CCNT1 p.Ser499Gly Uncertain significance Single submitter
- CCNT1 p.Ser531Thr Uncertain significance Single submitter
- CCNT1 p.Ser548Asn Uncertain significance Single submitter
- CCNT1 p.Ser552Asn Uncertain significance Single submitter
- CCNT1 p.Ser552Gly Uncertain significance Single submitter
- CCNT1 p.Thr267Arg Uncertain significance Single submitter
- CCNT1 p.Thr295Ser Uncertain significance Single submitter
- CCNT1 p.Thr679Ser Uncertain significance Single submitter
- CCNT1 p.Tyr657Ser Uncertain significance Single submitter
- CCNT1 p.Val326Met Uncertain significance Single submitter
- CCNT1 p.Val360Ala Uncertain significance Single submitter
- CCNT1 p.Val435Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CCNT1 p.Ala397Val Uncertain significance Single submitter
- CCNT1 p.Arg483Cys Uncertain significance Single submitter
- CCNT1 p.Arg483Leu Uncertain significance Single submitter
- CCNT1 p.Met71Thr Uncertain significance Single submitter
- CCNT1 p.Pro79Leu Uncertain significance Single submitter
- CCNT1 p.Ser564Phe Uncertain significance Single submitter
- CCNT1 p.Tyr418His Uncertain significance Single submitter
All CCNT1 variants
Likely benign 5
- p.Leu452= Single submitter
- p.Lys277Asn Single submitter
- p.Lys332Glu Single submitter
- p.Ser688Gly Single submitter
- p.Val535Ala Single submitter
Uncertain significance 66
- p.Ala356Glu Single submitter ⚠
- p.Ala394Thr Single submitter ⚠
- p.Ala394Val Single submitter ⚠
- p.Ala397Val Single submitter ⚠
- p.Ala489Val Single submitter ⚠
- p.Arg25Gly Single submitter ⚠
- p.Arg333Cys Single submitter ⚠
- p.Arg333His Single submitter ⚠
- p.Arg393His Single submitter ⚠
- p.Arg449Trp Single submitter ⚠
- p.Arg463Lys Single submitter ⚠
- p.Arg483Cys Single submitter ⚠
- p.Arg483Leu Single submitter ⚠
- p.Arg504Gln Single submitter ⚠
- p.Arg633His Single submitter ⚠
- p.Arg694Gln Single submitter ⚠
- p.Arg709Trp Single submitter ⚠
- p.Asn494Asp Single submitter ⚠
- p.Asn494Ser Single submitter ⚠
- p.Asn522His Single submitter ⚠
- p.Asp367Asn Single submitter ⚠
- p.Asp456Gly Single submitter ⚠
- p.Asp470Gly Single submitter ⚠
- p.Cys630Tyr Single submitter ⚠
- p.Gln281His Single submitter ⚠
- p.Gln289Pro Single submitter ⚠
- p.Gln532His Single submitter ⚠
- p.Glu442Val Single submitter ⚠
- p.Glu508Val Single submitter ⚠
- p.Gly273Glu Single submitter ⚠
- p.Gly543Ser Single submitter ⚠
- p.Gly582Arg Single submitter ⚠
- p.His362Asp Single submitter ⚠
- p.His517Tyr Single submitter ⚠
- p.His616Arg Single submitter ⚠
- p.His665Pro Single submitter ⚠
- p.Ile150Phe Single submitter ⚠
- p.Ile436Thr Single submitter ⚠
- p.Leu133Val Single submitter ⚠
- p.Leu90Val Single submitter ⚠
- p.Lys457Arg Single submitter ⚠
- p.Met328Leu Single submitter ⚠
- p.Met439Thr Single submitter ⚠
- p.Met613Ile Single submitter ⚠
- p.Met71Thr Single submitter ⚠
- p.Pro330Ala Single submitter ⚠
- p.Pro383Ala Single submitter ⚠
- p.Pro477Leu Single submitter ⚠
- p.Pro712Arg Single submitter ⚠
- p.Pro79Leu Single submitter ⚠
- p.Ser352Gly Single submitter ⚠
- p.Ser36Pro Single submitter ⚠
- p.Ser499Gly Single submitter ⚠
- p.Ser531Thr Single submitter ⚠
- p.Ser548Asn Single submitter ⚠
- p.Ser552Asn Single submitter ⚠
- p.Ser552Gly Single submitter ⚠
- p.Ser564Phe Single submitter ⚠
- p.Thr267Arg Single submitter ⚠
- p.Thr295Ser Single submitter ⚠
- p.Thr679Ser Single submitter ⚠
- p.Tyr418His Single submitter ⚠
- p.Tyr657Ser Single submitter ⚠
- p.Val326Met Single submitter ⚠
- p.Val360Ala Single submitter ⚠
- p.Val435Ile Single submitter ⚠