CCNT2 — 65 ClinVar variants
All ClinVar germline CCNT2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
5 Likely benign · 60 Uncertain significance
Full CCNT2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCNT2 p.Asp717Asn Uncertain significance Multiple submitters
- CCNT2 p.Ala335Ser Uncertain significance Single submitter
- CCNT2 p.Ala458Thr Uncertain significance Single submitter
- CCNT2 p.Asn700Ser Uncertain significance Single submitter
- CCNT2 p.Asn729Ser Uncertain significance Single submitter
- CCNT2 p.Asp688His Uncertain significance Single submitter
- CCNT2 p.Gln271Glu Uncertain significance Single submitter
- CCNT2 p.Gln323His Uncertain significance Single submitter
- CCNT2 p.Gln708Arg Uncertain significance Single submitter
- CCNT2 p.Glu702Gln Uncertain significance Single submitter
- CCNT2 p.Gly374Ala Uncertain significance Single submitter
- CCNT2 p.Gly384Glu Uncertain significance Single submitter
- CCNT2 p.Gly415Glu Uncertain significance Single submitter
- CCNT2 p.Gly585Ser Uncertain significance Single submitter
- CCNT2 p.Gly593Arg Uncertain significance Single submitter
- CCNT2 p.Gly604Ala Uncertain significance Single submitter
- CCNT2 p.Gly609Asp Uncertain significance Single submitter
- CCNT2 p.Gly696Ser Uncertain significance Single submitter
- CCNT2 p.His560Asp Uncertain significance Single submitter
- CCNT2 p.His658Leu Uncertain significance Single submitter
- CCNT2 p.His664Leu Uncertain significance Single submitter
- CCNT2 p.Ile320Val Uncertain significance Single submitter
- CCNT2 p.Ile379Leu Uncertain significance Single submitter
- CCNT2 p.Ile379Val Uncertain significance Single submitter
- CCNT2 p.Ile429Met Uncertain significance Single submitter
- CCNT2 p.Ile511Val Uncertain significance Single submitter
- CCNT2 p.Leu278His Uncertain significance Single submitter
- CCNT2 p.Leu282Val Uncertain significance Single submitter
- CCNT2 p.Leu687Pro Uncertain significance Single submitter
- CCNT2 p.Lys442Thr Uncertain significance Single submitter
- CCNT2 p.Pro595Leu Uncertain significance Single submitter
- CCNT2 p.Ser365Leu Uncertain significance Single submitter
- CCNT2 p.Ser531Pro Uncertain significance Single submitter
- CCNT2 p.Thr327Ala Uncertain significance Single submitter
- CCNT2 p.Thr360Ala Uncertain significance Single submitter
- CCNT2 p.Thr426Ala Uncertain significance Single submitter
- CCNT2 p.Thr75Ser Uncertain significance Single submitter
- CCNT2 p.Val268Ala Uncertain significance Single submitter
- CCNT2 p.Val598Ile Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- CCNT2 p.Arg255Gln Uncertain significance Single submitter
- CCNT2 p.Asn208Asp Uncertain significance Single submitter
- CCNT2 p.Asp119Glu Uncertain significance Single submitter
- CCNT2 p.Asp688Tyr Uncertain significance Single submitter
- CCNT2 p.Gly727Ala Uncertain significance Single submitter
- CCNT2 p.His394Tyr Uncertain significance Single submitter
- CCNT2 p.His551Tyr Uncertain significance Single submitter
- CCNT2 p.His575Gln Uncertain significance Single submitter
- CCNT2 p.Ile509Phe Uncertain significance Single submitter
- CCNT2 p.Met139Val Uncertain significance Single submitter
- CCNT2 p.Met525Ile Uncertain significance Single submitter
- CCNT2 p.Met728Lys Uncertain significance Single submitter
- CCNT2 p.Phe716Leu Uncertain significance Single submitter
- CCNT2 p.Ser417Gly Uncertain significance Single submitter
- CCNT2 p.Ser435Phe Uncertain significance Single submitter
- CCNT2 p.Ser566Gly Uncertain significance Single submitter
- CCNT2 p.Ser646Asn Uncertain significance Single submitter
- CCNT2 p.Ser706Asn Likely benign Single submitter
- CCNT2 p.Ser707Ile Uncertain significance Single submitter
- CCNT2 p.Ser8Phe Uncertain significance Single submitter
- CCNT2 p.Val163Ile Uncertain significance Single submitter
All CCNT2 variants
Likely benign 5
- p.Cys36Tyr Single submitter
- p.Ile387Val Single submitter
- p.Leu684= Single submitter
- p.Lys690= Single submitter
- p.Ser706Asn Single submitter ⚠
Uncertain significance 60
- p.Asp717Asn Multiple submitters ⚠
- p.Ala335Ser Single submitter ⚠
- p.Ala458Thr Single submitter ⚠
- p.Arg255Gln Single submitter ⚠
- p.Asn208Asp Single submitter ⚠
- p.Asn700Ser Single submitter ⚠
- p.Asn729Ser Single submitter ⚠
- p.Asp119Glu Single submitter ⚠
- p.Asp688His Single submitter ⚠
- p.Asp688Tyr Single submitter ⚠
- p.Gln271Glu Single submitter ⚠
- p.Gln323His Single submitter ⚠
- p.Gln708Arg Single submitter ⚠
- p.Glu702Gln Single submitter ⚠
- p.Gly374Ala Single submitter ⚠
- p.Gly384Glu Single submitter ⚠
- p.Gly415Glu Single submitter ⚠
- p.Gly585Ser Single submitter ⚠
- p.Gly593Arg Single submitter ⚠
- p.Gly604Ala Single submitter ⚠
- p.Gly609Asp Single submitter ⚠
- p.Gly696Ser Single submitter ⚠
- p.Gly727Ala Single submitter ⚠
- p.His394Tyr Single submitter ⚠
- p.His551Tyr Single submitter ⚠
- p.His560Asp Single submitter ⚠
- p.His575Gln Single submitter ⚠
- p.His658Leu Single submitter ⚠
- p.His664Leu Single submitter ⚠
- p.Ile320Val Single submitter ⚠
- p.Ile379Leu Single submitter ⚠
- p.Ile379Val Single submitter ⚠
- p.Ile429Met Single submitter ⚠
- p.Ile509Phe Single submitter ⚠
- p.Ile511Val Single submitter ⚠
- p.Leu278His Single submitter ⚠
- p.Leu282Val Single submitter ⚠
- p.Leu687Pro Single submitter ⚠
- p.Lys442Thr Single submitter ⚠
- p.Met139Val Single submitter ⚠
- p.Met525Ile Single submitter ⚠
- p.Met728Lys Single submitter ⚠
- p.Phe716Leu Single submitter ⚠
- p.Pro595Leu Single submitter ⚠
- p.Ser365Leu Single submitter ⚠
- p.Ser417Gly Single submitter ⚠
- p.Ser435Phe Single submitter ⚠
- p.Ser531Pro Single submitter ⚠
- p.Ser566Gly Single submitter ⚠
- p.Ser646Asn Single submitter ⚠
- p.Ser707Ile Single submitter ⚠
- p.Ser8Phe Single submitter ⚠
- p.Thr327Ala Single submitter ⚠
- p.Thr360Ala Single submitter ⚠
- p.Thr426Ala Single submitter ⚠
- p.Thr75Ser Single submitter ⚠
- p.Val163Ile Single submitter ⚠
- p.Val268Ala Single submitter ⚠
- p.Val598Ile Single submitter ⚠
- c.430+1G>C No assertion criteria premature menopause