CCNYL1 — 36 ClinVar variants
All ClinVar germline CCNYL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
4 Likely benign · 32 Uncertain significance
Full CCNYL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCNYL1 p.Ala24Val Uncertain significance Single submitter
- CCNYL1 p.Ala338Thr Uncertain significance Single submitter
- CCNYL1 p.Ala44Thr Uncertain significance Single submitter
- CCNYL1 p.Arg299Cys Uncertain significance Single submitter
- CCNYL1 p.Arg353His Uncertain significance Single submitter
- CCNYL1 p.Glu57Gly Uncertain significance Single submitter
- CCNYL1 p.Glu59Lys Uncertain significance Single submitter
- CCNYL1 p.His62Tyr Uncertain significance Single submitter
- CCNYL1 p.Ile153Val Uncertain significance Single submitter
- CCNYL1 p.Leu241Phe Uncertain significance Single submitter
- CCNYL1 p.Leu310Val Uncertain significance Single submitter
- CCNYL1 p.Leu314Val Uncertain significance Single submitter
- CCNYL1 p.Lys355Glu Uncertain significance Single submitter
- CCNYL1 p.Met339Val Uncertain significance Single submitter
- CCNYL1 p.Met71Ile Uncertain significance Single submitter
- CCNYL1 p.Pro313Leu Uncertain significance Single submitter
- CCNYL1 p.Pro72Thr Uncertain significance Single submitter
- CCNYL1 p.Ser79Ala Uncertain significance Single submitter
- CCNYL1 p.Thr197Pro Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CCNYL1 p.Ala345Val Uncertain significance Single submitter
- CCNYL1 p.Arg20Cys Uncertain significance Single submitter
- CCNYL1 p.Arg340Gly Uncertain significance Single submitter
- CCNYL1 p.Asp54Tyr Uncertain significance Single submitter
- CCNYL1 p.Cys8Trp Uncertain significance Single submitter
- CCNYL1 p.Ile149Val Uncertain significance Single submitter
- CCNYL1 p.Ile325Val Uncertain significance Single submitter
- CCNYL1 p.Pro72Arg Uncertain significance Single submitter
- CCNYL1 p.Ser10Cys Uncertain significance Single submitter
- CCNYL1 p.Ser10Phe Uncertain significance Single submitter
- CCNYL1 p.Ser14Thr Uncertain significance Single submitter
- CCNYL1 p.Ser300Phe Uncertain significance Single submitter
- CCNYL1 p.Ser93Asn Uncertain significance Single submitter
All CCNYL1 variants
Likely benign 4
- c.220+2302T>A Single submitter
- p.Ala288= Single submitter
- p.Arg174= Single submitter
- p.Ile32Val Single submitter
Uncertain significance 32
- p.Ala24Val Single submitter ⚠
- p.Ala338Thr Single submitter ⚠
- p.Ala345Val Single submitter ⚠
- p.Ala44Thr Single submitter ⚠
- p.Arg20Cys Single submitter ⚠
- p.Arg299Cys Single submitter ⚠
- p.Arg340Gly Single submitter ⚠
- p.Arg353His Single submitter ⚠
- p.Asp54Tyr Single submitter ⚠
- p.Cys8Trp Single submitter ⚠
- p.Glu57Gly Single submitter ⚠
- p.Glu59Lys Single submitter ⚠
- p.His62Tyr Single submitter ⚠
- p.Ile149Val Single submitter ⚠
- p.Ile153Val Single submitter ⚠
- p.Ile325Val Single submitter ⚠
- p.Leu241Phe Single submitter ⚠
- p.Leu310Val Single submitter ⚠
- p.Leu314Val Single submitter ⚠
- p.Lys355Glu Single submitter ⚠
- p.Met339Val Single submitter ⚠
- p.Met71Ile Single submitter ⚠
- p.Pro313Leu Single submitter ⚠
- p.Pro72Arg Single submitter ⚠
- p.Pro72Thr Single submitter ⚠
- p.Ser10Cys Single submitter ⚠
- p.Ser10Phe Single submitter ⚠
- p.Ser14Thr Single submitter ⚠
- p.Ser300Phe Single submitter ⚠
- p.Ser79Ala Single submitter ⚠
- p.Ser93Asn Single submitter ⚠
- p.Thr197Pro Single submitter ⚠