CCP110 — 140 ClinVar variants
All ClinVar germline CCP110 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 121 flagged for review →
2 Likely pathogenic · 9 Benign · 8 Likely benign · 121 Uncertain significance
Full CCP110 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 121
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 86
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCP110 c.2900+517G>C Uncertain significance Single submitter
- CCP110 c.2900+527T>C Uncertain significance Single submitter
- CCP110 c.2900+581T>C Uncertain significance Single submitter
- CCP110 p.Ala193Val Uncertain significance Single submitter
- CCP110 p.Ala217Val Uncertain significance Single submitter
- CCP110 p.Ala309Thr Uncertain significance Single submitter
- CCP110 p.Ala433Val Uncertain significance Single submitter
- CCP110 p.Ala700Val Uncertain significance Single submitter
- CCP110 p.Ala731Thr Uncertain significance Single submitter
- CCP110 p.Ala957Val Uncertain significance Single submitter
- CCP110 p.Ala977= Uncertain significance Single submitter
- CCP110 p.Arg379His Uncertain significance Single submitter
- CCP110 p.Arg37His Uncertain significance Single submitter
- CCP110 p.Arg586Gln Uncertain significance Single submitter
- CCP110 p.Arg680Lys Uncertain significance Single submitter
- CCP110 p.Arg882Ile Uncertain significance Single submitter
- CCP110 p.Arg908Gln Uncertain significance Single submitter
- CCP110 p.Arg961Lys Uncertain significance Single submitter
- CCP110 p.Asn392Ser Uncertain significance Single submitter
- CCP110 p.Asn88Ser Uncertain significance Single submitter
- CCP110 p.Asn96Ile Uncertain significance Single submitter
- CCP110 p.Cys154Tyr Uncertain significance Single submitter
- CCP110 p.Cys273Tyr Uncertain significance Single submitter
- CCP110 p.Cys498Ser Uncertain significance Single submitter
- CCP110 p.Cys981= Uncertain significance Single submitter
- CCP110 p.Gln463Arg Uncertain significance Single submitter
- CCP110 p.Gln483Arg Uncertain significance Single submitter
- CCP110 p.Gln556Arg Uncertain significance Single submitter
- CCP110 p.Gln83Glu Uncertain significance Single submitter
- CCP110 p.Gln955Glu Uncertain significance Single submitter
- CCP110 p.Glu197Gln Uncertain significance Single submitter
- CCP110 p.Glu3Lys Uncertain significance Single submitter
- CCP110 p.Glu481Lys Uncertain significance Single submitter
- CCP110 p.Glu67Val Uncertain significance Single submitter
- CCP110 p.His468Tyr Uncertain significance Single submitter
- CCP110 p.Ile15Val Uncertain significance Single submitter
- CCP110 p.Ile239Val Uncertain significance Single submitter
- CCP110 p.Ile325Leu Uncertain significance Single submitter
- CCP110 p.Ile834Met Uncertain significance Single submitter
- CCP110 p.Ile847Thr Uncertain significance Single submitter
- CCP110 p.Leu139Pro Uncertain significance Single submitter
- CCP110 p.Leu335Pro Uncertain significance Single submitter
- CCP110 p.Leu35Phe Uncertain significance Single submitter
- CCP110 p.Leu669Val Uncertain significance Single submitter
- CCP110 p.Lys322Glu Uncertain significance Single submitter
- CCP110 p.Lys355Arg Uncertain significance Single submitter
- CCP110 p.Lys363Arg Uncertain significance Single submitter
- CCP110 p.Lys427Glu Uncertain significance Single submitter
- CCP110 p.Lys52Thr Uncertain significance Single submitter
- CCP110 p.Lys648Arg Uncertain significance Single submitter
- CCP110 p.Lys6Thr Uncertain significance Single submitter
- CCP110 p.Lys76Glu Uncertain significance Single submitter
- CCP110 p.Lys905Arg Uncertain significance Single submitter
- CCP110 p.Lys936Thr Uncertain significance Single submitter
- CCP110 p.Met232Ile Uncertain significance Single submitter
- CCP110 p.Met312Leu Uncertain significance Single submitter
- CCP110 p.Met312Thr Uncertain significance Single submitter
- CCP110 p.Met568Val Uncertain significance Single submitter
- CCP110 p.Met633Val Uncertain significance Single submitter
- CCP110 p.Met897Ile Uncertain significance Single submitter
- CCP110 p.Met901Leu Uncertain significance Single submitter
- CCP110 p.Met932Thr Uncertain significance Single submitter
- CCP110 p.Pro293Arg Uncertain significance Single submitter
- CCP110 p.Pro552Ser Uncertain significance Single submitter
- CCP110 p.Pro601Leu Uncertain significance Single submitter
- CCP110 p.Pro617Ser Uncertain significance Single submitter
- CCP110 p.Pro760Ser Uncertain significance Single submitter
- CCP110 p.Pro907Ser Uncertain significance Single submitter
- CCP110 p.Pro958Ser Uncertain significance Single submitter
- CCP110 p.Pro958Thr Uncertain significance Single submitter
- CCP110 p.Ser637Ile Uncertain significance Single submitter
- CCP110 p.Ser703Pro Uncertain significance Single submitter
- CCP110 p.Ser964Asn Uncertain significance Single submitter
- CCP110 p.Thr131Met Uncertain significance Single submitter
- CCP110 p.Thr768Ala Uncertain significance Single submitter
- CCP110 p.Thr785Ile Uncertain significance Single submitter
- CCP110 p.Thr946Ala Uncertain significance Single submitter
- CCP110 p.Tyr602Cys Uncertain significance Single submitter
- CCP110 p.Tyr621Ser Uncertain significance Single submitter
- CCP110 p.Tyr924His Uncertain significance Single submitter
- CCP110 p.Val207Ile Uncertain significance Single submitter
- CCP110 p.Val323Ala Uncertain significance Single submitter
- CCP110 p.Val348Ile Uncertain significance Single submitter
- CCP110 p.Val440Phe Uncertain significance Single submitter
- CCP110 p.Val473Leu Uncertain significance Single submitter
- CCP110 p.Val547Ile Uncertain significance Single submitter
Predictors split 35
The independent predictors disagree with each other — read with care.
- CCP110 c.2900+526G>T Uncertain significance Single submitter
- CCP110 p.Ala927Val Uncertain significance Single submitter
- CCP110 p.Arg246His Uncertain significance Single submitter
- CCP110 p.Arg377Gln Uncertain significance Single submitter
- CCP110 p.Arg37Cys Uncertain significance Single submitter
- CCP110 p.Arg381Gly Uncertain significance Single submitter
- CCP110 p.Arg81His Uncertain significance Single submitter
- CCP110 p.Arg890Gln Uncertain significance Single submitter
- CCP110 p.Arg893His Uncertain significance Single submitter
- CCP110 p.Asp818Asn Uncertain significance Single submitter
- CCP110 p.Cys981Ter Uncertain significance Single submitter
- CCP110 p.Glu350Lys Uncertain significance Single submitter
- CCP110 p.Glu3Val Uncertain significance Single submitter
- CCP110 p.Glu642Lys Uncertain significance Single submitter
- CCP110 p.Glu675Asp Uncertain significance Single submitter
- CCP110 p.Glu686Lys Uncertain significance Single submitter
- CCP110 p.His871Tyr Uncertain significance Single submitter
- CCP110 p.His888Asn Uncertain significance Single submitter
- CCP110 p.Ile390Thr Uncertain significance Single submitter
- CCP110 p.Ile394Lys Uncertain significance Single submitter
- CCP110 p.Ile885Val Uncertain significance Single submitter
- CCP110 p.Leu231Met Uncertain significance Single submitter
- CCP110 p.Leu248Pro Uncertain significance Single submitter
- CCP110 p.Leu48Phe Uncertain significance Single submitter
- CCP110 p.Leu645Pro Uncertain significance Single submitter
- CCP110 p.Leu670Phe Uncertain significance Single submitter
- CCP110 p.Met56Thr Uncertain significance Single submitter
- CCP110 p.Pro373Leu Uncertain significance Single submitter
- CCP110 p.Pro393Arg Uncertain significance Single submitter
- CCP110 p.Pro393Thr Uncertain significance Single submitter
- CCP110 p.Ser177Cys Uncertain significance Single submitter
- CCP110 p.Ser742Cys Uncertain significance Single submitter
- CCP110 p.Thr605Ile Uncertain significance Single submitter
- CCP110 p.Val892Phe Uncertain significance Single submitter
- CCP110 p.Val909Met Uncertain significance Single submitter
All CCP110 variants
Likely pathogenic 2
- p.Arg377Ter No assertion criteria
- p.Val286fs No assertion criteria
Benign 9
- p.Ala433= Multiple submitters
- p.Arg845= Multiple submitters
- p.Asn740= Multiple submitters
- p.Ile252Met Multiple submitters
- p.Lys583= Multiple submitters
- p.Met375Ile Multiple submitters
- p.Pro171Leu Multiple submitters
- p.Thr122= Multiple submitters
- p.Thr560Met Multiple submitters
Likely benign 8
- p.Ala731Val Single submitter
- p.Asp982Asn Single submitter
- p.Glu661= Single submitter
- p.Lys975Glu Single submitter
- p.Met105Thr Single submitter
- p.Met425Val Single submitter
- p.Thr609= Single submitter
- p.Val628Ile Single submitter
Uncertain significance 121
- c.2900+517G>C Single submitter ⚠
- c.2900+526G>T Single submitter ⚠
- c.2900+527T>C Single submitter ⚠
- c.2900+581T>C Single submitter ⚠
- p.Ala193Val Single submitter ⚠
- p.Ala217Val Single submitter ⚠
- p.Ala309Thr Single submitter ⚠
- p.Ala433Val Single submitter ⚠
- p.Ala700Val Single submitter ⚠
- p.Ala731Thr Single submitter ⚠
- p.Ala927Val Single submitter ⚠
- p.Ala957Val Single submitter ⚠
- p.Ala977= Single submitter ⚠
- p.Arg246His Single submitter ⚠
- p.Arg377Gln Single submitter ⚠
- p.Arg379His Single submitter ⚠
- p.Arg37Cys Single submitter ⚠
- p.Arg37His Single submitter ⚠
- p.Arg381Gly Single submitter ⚠
- p.Arg586Gln Single submitter ⚠
- p.Arg680Lys Single submitter ⚠
- p.Arg81His Single submitter ⚠
- p.Arg882Ile Single submitter ⚠
- p.Arg890Gln Single submitter ⚠
- p.Arg893His Single submitter ⚠
- p.Arg908Gln Single submitter ⚠
- p.Arg961Lys Single submitter ⚠
- p.Asn392Ser Single submitter ⚠
- p.Asn88Ser Single submitter ⚠
- p.Asn96Ile Single submitter ⚠
- p.Asp818Asn Single submitter ⚠
- p.Cys154Tyr Single submitter ⚠
- p.Cys273Tyr Single submitter ⚠
- p.Cys498Ser Single submitter ⚠
- p.Cys981= Single submitter ⚠
- p.Cys981Ter Single submitter ⚠
- p.Gln463Arg Single submitter ⚠
- p.Gln483Arg Single submitter ⚠
- p.Gln556Arg Single submitter ⚠
- p.Gln83Glu Single submitter ⚠
- p.Gln955Glu Single submitter ⚠
- p.Glu197Gln Single submitter ⚠
- p.Glu350Lys Single submitter ⚠
- p.Glu3Lys Single submitter ⚠
- p.Glu3Val Single submitter ⚠
- p.Glu481Lys Single submitter ⚠
- p.Glu642Lys Single submitter ⚠
- p.Glu675Asp Single submitter ⚠
- p.Glu67Val Single submitter ⚠
- p.Glu686Lys Single submitter ⚠
- p.His468Tyr Single submitter ⚠
- p.His871Tyr Single submitter ⚠
- p.His888Asn Single submitter ⚠
- p.Ile15Val Single submitter ⚠
- p.Ile239Val Single submitter ⚠
- p.Ile325Leu Single submitter ⚠
- p.Ile390Thr Single submitter ⚠
- p.Ile394Lys Single submitter ⚠
- p.Ile834Met Single submitter ⚠
- p.Ile847Thr Single submitter ⚠
- p.Ile885Val Single submitter ⚠
- p.Leu139Pro Single submitter ⚠
- p.Leu231Met Single submitter ⚠
- p.Leu248Pro Single submitter ⚠
- p.Leu335Pro Single submitter ⚠
- p.Leu35Phe Single submitter ⚠
- p.Leu48Phe Single submitter ⚠
- p.Leu645Pro Single submitter ⚠
- p.Leu669Val Single submitter ⚠
- p.Leu670Phe Single submitter ⚠
- p.Lys322Glu Single submitter ⚠
- p.Lys355Arg Single submitter ⚠
- p.Lys363Arg Single submitter ⚠
- p.Lys427Glu Single submitter ⚠
- p.Lys52Thr Single submitter ⚠
- p.Lys648Arg Single submitter ⚠
- p.Lys6Thr Single submitter ⚠
- p.Lys76Glu Single submitter ⚠
- p.Lys905Arg Single submitter ⚠
- p.Lys936Thr Single submitter ⚠
- p.Met232Ile Single submitter ⚠
- p.Met312Leu Single submitter ⚠
- p.Met312Thr Single submitter ⚠
- p.Met568Val Single submitter ⚠
- p.Met56Thr Single submitter ⚠
- p.Met633Val Single submitter ⚠
- p.Met897Ile Single submitter ⚠
- p.Met901Leu Single submitter ⚠
- p.Met932Thr Single submitter ⚠
- p.Pro293Arg Single submitter ⚠
- p.Pro373Leu Single submitter ⚠
- p.Pro393Arg Single submitter ⚠
- p.Pro393Thr Single submitter ⚠
- p.Pro552Ser Single submitter ⚠
- p.Pro601Leu Single submitter ⚠
- p.Pro617Ser Single submitter ⚠
- p.Pro760Ser Single submitter ⚠
- p.Pro907Ser Single submitter ⚠
- p.Pro958Ser Single submitter ⚠
- p.Pro958Thr Single submitter ⚠
- p.Ser177Cys Single submitter ⚠
- p.Ser637Ile Single submitter ⚠
- p.Ser703Pro Single submitter ⚠
- p.Ser742Cys Single submitter ⚠
- p.Ser964Asn Single submitter ⚠
- p.Thr131Met Single submitter ⚠
- p.Thr605Ile Single submitter ⚠
- p.Thr768Ala Single submitter ⚠
- p.Thr785Ile Single submitter ⚠
- p.Thr946Ala Single submitter ⚠
- p.Tyr602Cys Single submitter ⚠
- p.Tyr621Ser Single submitter ⚠
- p.Tyr924His Single submitter ⚠
- p.Val207Ile Single submitter ⚠
- p.Val323Ala Single submitter ⚠
- p.Val348Ile Single submitter ⚠
- p.Val440Phe Single submitter ⚠
- p.Val473Leu Single submitter ⚠
- p.Val547Ile Single submitter ⚠
- p.Val892Phe Single submitter ⚠
- p.Val909Met Single submitter ⚠