CCR1 — 51 ClinVar variants
All ClinVar germline CCR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
4 Benign · 2 Benign/Likely benign · 10 Likely benign · 35 Uncertain significance
Full CCR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCR1 p.Ala159Ser Uncertain significance Single submitter
- CCR1 p.Ala200Val Uncertain significance Single submitter
- CCR1 p.Ala31Asp Uncertain significance Single submitter
- CCR1 p.Ala31Thr Uncertain significance Single submitter
- CCR1 p.Arg319Cys Uncertain significance Single submitter
- CCR1 p.Asp280Glu Uncertain significance Single submitter
- CCR1 p.Gln35His Uncertain significance Single submitter
- CCR1 p.Glu337Gln Uncertain significance Single submitter
- CCR1 p.Glu350Gln Uncertain significance Single submitter
- CCR1 p.His271Arg Uncertain significance Single submitter
- CCR1 p.Ile225Thr Uncertain significance Single submitter
- CCR1 p.Leu185Phe Uncertain significance Single submitter
- CCR1 p.Phe248Val Uncertain significance Single submitter
- CCR1 p.Thr153Ser Uncertain significance Single submitter
- CCR1 p.Thr220Ile Uncertain significance Single submitter
- CCR1 p.Thr258Pro Uncertain significance Single submitter
- CCR1 p.Tyr118Asp Uncertain significance Single submitter
- CCR1 p.Val100Ala Uncertain significance Single submitter
- CCR1 p.Val333Met Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CCR1 p.Ala290Thr Likely benign Single submitter
- CCR1 p.Arg309Trp Uncertain significance Single submitter
- CCR1 p.Arg30Gly Uncertain significance Single submitter
- CCR1 p.Arg30Ser Uncertain significance Single submitter
- CCR1 p.Arg313Gln Uncertain significance Single submitter
- CCR1 p.Arg319Gly Uncertain significance Single submitter
- CCR1 p.Gly221Glu Uncertain significance Single submitter
- CCR1 p.Ile259Thr Uncertain significance Single submitter
- CCR1 p.Leu37Met Uncertain significance Single submitter
- CCR1 p.Phe122Leu Uncertain significance Single submitter
- CCR1 p.Pro230Gln Uncertain significance Single submitter
- CCR1 p.Pro39Thr Uncertain significance Single submitter
- CCR1 p.Ser340Ile Uncertain significance Single submitter
- CCR1 p.Ser345Pro Uncertain significance Single submitter
- CCR1 p.Thr86Met Uncertain significance Single submitter
- CCR1 p.Val147Ile Uncertain significance Single submitter
- CCR1 p.Val58Ile Uncertain significance Single submitter
All CCR1 variants
Benign 4
- p.Leu127= Multiple submitters
- p.Ter356= Multiple submitters
- p.Tyr291His Multiple submitters
- p.Arg338= Single submitter
Likely benign 10
- p.Ala159Val Multiple submitters
- p.Ala290Thr Single submitter ⚠
- p.Arg193Gln Single submitter
- p.His181Tyr Single submitter
- p.Ser332= Single submitter
- p.Thr146= Single submitter
- p.Thr182Ser Single submitter
- p.Thr286= Single submitter
- p.Tyr18= Single submitter
- p.Tyr219= Single submitter
Uncertain significance 35
- p.Ala159Ser Single submitter ⚠
- p.Ala200Val Single submitter ⚠
- p.Ala31Asp Single submitter ⚠
- p.Ala31Thr Single submitter ⚠
- p.Arg309Trp Single submitter ⚠
- p.Arg30Gly Single submitter ⚠
- p.Arg30Ser Single submitter ⚠
- p.Arg313Gln Single submitter ⚠
- p.Arg319Cys Single submitter ⚠
- p.Arg319Gly Single submitter ⚠
- p.Asp280Glu Single submitter ⚠
- p.Gln35His Single submitter ⚠
- p.Glu337Gln Single submitter ⚠
- p.Glu350Gln Single submitter ⚠
- p.Gly221Glu Single submitter ⚠
- p.His271Arg Single submitter ⚠
- p.Ile225Thr Single submitter ⚠
- p.Ile259Thr Single submitter ⚠
- p.Leu185Phe Single submitter ⚠
- p.Leu37Met Single submitter ⚠
- p.Phe122Leu Single submitter ⚠
- p.Phe248Val Single submitter ⚠
- p.Pro230Gln Single submitter ⚠
- p.Pro39Thr Single submitter ⚠
- p.Ser340Ile Single submitter ⚠
- p.Ser345Pro Single submitter ⚠
- p.Thr153Ser Single submitter ⚠
- p.Thr220Ile Single submitter ⚠
- p.Thr258Pro Single submitter ⚠
- p.Thr86Met Single submitter ⚠
- p.Tyr118Asp Single submitter ⚠
- p.Val100Ala Single submitter ⚠
- p.Val147Ile Single submitter ⚠
- p.Val333Met Single submitter ⚠
- p.Val58Ile Single submitter ⚠