CCR3 — 59 ClinVar variants
All ClinVar germline CCR3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
6 Likely benign · 53 Uncertain significance
Full CCR3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCR3 p.Ala138Ser Uncertain significance Single submitter
- CCR3 p.Ala216Thr Uncertain significance Single submitter
- CCR3 p.Ala246Thr Uncertain significance Single submitter
- CCR3 p.Arg143Gln Uncertain significance Single submitter
- CCR3 p.Arg95Lys Uncertain significance Single submitter
- CCR3 p.Asn256Asp Uncertain significance Single submitter
- CCR3 p.Asn52Thr Uncertain significance Single submitter
- CCR3 p.Asn98Ser Uncertain significance Single submitter
- CCR3 p.Asp190Gly Uncertain significance Single submitter
- CCR3 p.Glu25Val Uncertain significance Single submitter
- CCR3 p.Gly102Asp Uncertain significance Single submitter
- CCR3 p.Gly159Asp Uncertain significance Single submitter
- CCR3 p.His199Gln Uncertain significance Single submitter
- CCR3 p.Ile155Thr Uncertain significance Single submitter
- CCR3 p.Ile259Phe Uncertain significance Single submitter
- CCR3 p.Ile67Phe Uncertain significance Single submitter
- CCR3 p.Ile78Val Uncertain significance Single submitter
- CCR3 p.Leu117Phe Uncertain significance Single submitter
- CCR3 p.Leu321Arg Uncertain significance Single submitter
- CCR3 p.Leu351Arg Uncertain significance Single submitter
- CCR3 p.Met245Thr Uncertain significance Single submitter
- CCR3 p.Phe248Val Uncertain significance Single submitter
- CCR3 p.Pro349Leu Uncertain significance Single submitter
- CCR3 p.Ser15Phe Uncertain significance Single submitter
- CCR3 p.Ser15Thr Uncertain significance Single submitter
- CCR3 p.Ser79Leu Uncertain significance Single submitter
- CCR3 p.Thr10Ile Uncertain significance Single submitter
- CCR3 p.Thr153Ile Uncertain significance Single submitter
- CCR3 p.Thr204Ile Uncertain significance Single submitter
- CCR3 p.Thr7Ile Uncertain significance Single submitter
- CCR3 p.Tyr255Ser Uncertain significance Single submitter
- CCR3 p.Tyr327Ser Uncertain significance Single submitter
- CCR3 p.Val136Ala Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- CCR3 p.Arg202Thr Uncertain significance Single submitter
- CCR3 p.Arg239Gln Uncertain significance Single submitter
- CCR3 p.Arg307Ser Uncertain significance Single submitter
- CCR3 p.Arg309Gln Likely benign Single submitter
- CCR3 p.Arg309Trp Uncertain significance Single submitter
- CCR3 p.Arg313His Uncertain significance Single submitter
- CCR3 p.Asn75Ser Uncertain significance Single submitter
- CCR3 p.Asp18Gly Uncertain significance Single submitter
- CCR3 p.Cys294Ser Uncertain significance Single submitter
- CCR3 p.His92Arg Uncertain significance Single submitter
- CCR3 p.Lys224Gln Uncertain significance Single submitter
- CCR3 p.Met105Ile Uncertain significance Single submitter
- CCR3 p.Met68Ile Uncertain significance Single submitter
- CCR3 p.Phe83Leu Uncertain significance Single submitter
- CCR3 p.Pro188Ser Uncertain significance Single submitter
- CCR3 p.Pro230Ser Uncertain significance Single submitter
- CCR3 p.Ser343Phe Uncertain significance Single submitter
- CCR3 p.Thr86Ser Uncertain significance Single submitter
- CCR3 p.Val147Ala Uncertain significance Single submitter
- CCR3 p.Val304Phe Uncertain significance Single submitter
- CCR3 p.Val53Met Uncertain significance Single submitter
All CCR3 variants
Likely benign 6
- p.Ala246Val Single submitter
- p.Arg309Gln Single submitter ⚠
- p.Gly96Glu Single submitter
- p.Leu213= Single submitter
- p.Ser79= Single submitter
- p.Val151Ile Single submitter
Uncertain significance 53
- p.Ala138Ser Single submitter ⚠
- p.Ala216Thr Single submitter ⚠
- p.Ala246Thr Single submitter ⚠
- p.Arg143Gln Single submitter ⚠
- p.Arg202Thr Single submitter ⚠
- p.Arg239Gln Single submitter ⚠
- p.Arg307Ser Single submitter ⚠
- p.Arg309Trp Single submitter ⚠
- p.Arg313His Single submitter ⚠
- p.Arg95Lys Single submitter ⚠
- p.Asn256Asp Single submitter ⚠
- p.Asn52Thr Single submitter ⚠
- p.Asn75Ser Single submitter ⚠
- p.Asn98Ser Single submitter ⚠
- p.Asp18Gly Single submitter ⚠
- p.Asp190Gly Single submitter ⚠
- p.Cys294Ser Single submitter ⚠
- p.Glu25Val Single submitter ⚠
- p.Gly102Asp Single submitter ⚠
- p.Gly159Asp Single submitter ⚠
- p.His199Gln Single submitter ⚠
- p.His92Arg Single submitter ⚠
- p.Ile155Thr Single submitter ⚠
- p.Ile259Phe Single submitter ⚠
- p.Ile67Phe Single submitter ⚠
- p.Ile78Val Single submitter ⚠
- p.Leu117Phe Single submitter ⚠
- p.Leu321Arg Single submitter ⚠
- p.Leu351Arg Single submitter ⚠
- p.Lys224Gln Single submitter ⚠
- p.Met105Ile Single submitter ⚠
- p.Met245Thr Single submitter ⚠
- p.Met68Ile Single submitter ⚠
- p.Phe248Val Single submitter ⚠
- p.Phe83Leu Single submitter ⚠
- p.Pro188Ser Single submitter ⚠
- p.Pro230Ser Single submitter ⚠
- p.Pro349Leu Single submitter ⚠
- p.Ser15Phe Single submitter ⚠
- p.Ser15Thr Single submitter ⚠
- p.Ser343Phe Single submitter ⚠
- p.Ser79Leu Single submitter ⚠
- p.Thr10Ile Single submitter ⚠
- p.Thr153Ile Single submitter ⚠
- p.Thr204Ile Single submitter ⚠
- p.Thr7Ile Single submitter ⚠
- p.Thr86Ser Single submitter ⚠
- p.Tyr255Ser Single submitter ⚠
- p.Tyr327Ser Single submitter ⚠
- p.Val136Ala Single submitter ⚠
- p.Val147Ala Single submitter ⚠
- p.Val304Phe Single submitter ⚠
- p.Val53Met Single submitter ⚠