CCR4 — 34 ClinVar variants
All ClinVar germline CCR4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
2 Likely benign · 32 Uncertain significance
Full CCR4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CCR4 p.Ala246Thr Uncertain significance Single submitter
- CCR4 p.Ala246Val Uncertain significance Single submitter
- CCR4 p.Cys178Arg Uncertain significance Single submitter
- CCR4 p.Cys329Gly Uncertain significance Single submitter
- CCR4 p.Gln230Lys Uncertain significance Single submitter
- CCR4 p.His357Arg Uncertain significance Single submitter
- CCR4 p.Ile15Val Uncertain significance Single submitter
- CCR4 p.Leu21Gln Uncertain significance Single submitter
- CCR4 p.Leu325Phe Uncertain significance Single submitter
- CCR4 p.Leu334Val Uncertain significance Single submitter
- CCR4 p.Leu40His Uncertain significance Single submitter
- CCR4 p.Lys237Arg Uncertain significance Single submitter
- CCR4 p.Lys68Asn Uncertain significance Single submitter
- CCR4 p.Phe88Cys Uncertain significance Single submitter
- CCR4 p.Pro343Ser Uncertain significance Single submitter
- CCR4 p.Thr180Ser Uncertain significance Single submitter
- CCR4 p.Thr74Ile Uncertain significance Single submitter
- CCR4 p.Tyr153Cys Uncertain significance Single submitter
- CCR4 p.Val249Ile Uncertain significance Single submitter
- CCR4 p.Val327Gly Uncertain significance Single submitter
- CCR4 p.Val89Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CCR4 p.Arg147Trp Uncertain significance Single submitter
- CCR4 p.Ile208Met Uncertain significance Single submitter
- CCR4 p.Ile260Thr Uncertain significance Single submitter
- CCR4 p.Met129Leu Uncertain significance Single submitter
- CCR4 p.Met131Val Uncertain significance Single submitter
- CCR4 p.Met224Ile Uncertain significance Single submitter
- CCR4 p.Ser339Phe Uncertain significance Single submitter
- CCR4 p.Thr177Ile Uncertain significance Single submitter
- CCR4 p.Thr256Ala Uncertain significance Single submitter
- CCR4 p.Thr321Ile Uncertain significance Single submitter
- CCR4 p.Val327Met Uncertain significance Single submitter
All CCR4 variants
Likely benign 2
- p.Ile260Val Single submitter
- p.Phe173Leu Single submitter
Uncertain significance 32
- p.Ala246Thr Single submitter ⚠
- p.Ala246Val Single submitter ⚠
- p.Arg147Trp Single submitter ⚠
- p.Cys178Arg Single submitter ⚠
- p.Cys329Gly Single submitter ⚠
- p.Gln230Lys Single submitter ⚠
- p.His357Arg Single submitter ⚠
- p.Ile15Val Single submitter ⚠
- p.Ile208Met Single submitter ⚠
- p.Ile260Thr Single submitter ⚠
- p.Leu21Gln Single submitter ⚠
- p.Leu325Phe Single submitter ⚠
- p.Leu334Val Single submitter ⚠
- p.Leu40His Single submitter ⚠
- p.Lys237Arg Single submitter ⚠
- p.Lys68Asn Single submitter ⚠
- p.Met129Leu Single submitter ⚠
- p.Met131Val Single submitter ⚠
- p.Met224Ile Single submitter ⚠
- p.Phe88Cys Single submitter ⚠
- p.Pro343Ser Single submitter ⚠
- p.Ser339Phe Single submitter ⚠
- p.Thr177Ile Single submitter ⚠
- p.Thr180Ser Single submitter ⚠
- p.Thr256Ala Single submitter ⚠
- p.Thr321Ile Single submitter ⚠
- p.Thr74Ile Single submitter ⚠
- p.Tyr153Cys Single submitter ⚠
- p.Val249Ile Single submitter ⚠
- p.Val327Gly Single submitter ⚠
- p.Val327Met Single submitter ⚠
- p.Val89Met Single submitter ⚠